Literature DB >> 22103612

Development of biomarkers to optimize pediatric patient management: what makes children different?

Jennifer Goldman1, Mara L Becker, Bridgette Jones, Mark Clements, J Steven Leeder.   

Abstract

Despite the frequent utilization of biomarkers in medical practice, there is a relative paucity of information regarding validated pediatric biomarkers. Frequently, biomarkers found to be efficacious in adults are extrapolated to the pediatric clinical setting without considering that the pathogenesis of many diseases is distinctly different in children, and ontogeny directly influences disease evolution and therapeutic response in children. New and innovative approaches are necessary to provide reliable, validated biomarkers that can be used to improve and advance pediatric medical care.

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Year:  2011        PMID： 22103612      PMCID： PMC3321646          DOI： 10.2217/bmm.11.96

Source DB:  PubMed          Journal:  Biomark Med        ISSN： 1752-0363            Impact factor:   2.851


  82 in total

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Journal:  Eur J Hum Genet       Date:  2010-04-07       Impact factor: 4.246

Review 3.  Aspects of anticoagulation in children.

Authors:  Jeanette H Payne
Journal:  Br J Haematol       Date:  2010-05-26       Impact factor: 6.998

4.  A genome-wide study reveals copy number variants exclusive to childhood obesity cases.

Authors:  Joseph T Glessner; Jonathan P Bradfield; Kai Wang; Nagahide Takahashi; Haitao Zhang; Patrick M Sleiman; Frank D Mentch; Cecilia E Kim; Cuiping Hou; Kelly A Thomas; Maria L Garris; Sandra Deliard; Edward C Frackelton; F George Otieno; Jianhua Zhao; Rosetta M Chiavacci; Mingyao Li; Joseph D Buxbaum; Robert I Berkowitz; Hakon Hakonarson; Struan F A Grant
Journal:  Am J Hum Genet       Date:  2010-10-14       Impact factor: 11.025

Review 5.  Biomarkers of acute kidney injury in children: discovery, evaluation, and clinical application.

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Journal:  Pediatr Nephrol       Date:  2010-07-10       Impact factor: 3.714

Review 6.  Biomarkers in pediatrics: children as biomarker orphans.

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Review 9.  Pediatric inflammatory bowel disease: is it different?

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Journal:  Dig Dis       Date:  2009-09-24       Impact factor: 2.404

10.  A large-scale, consortium-based genomewide association study of asthma.

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Journal:  N Engl J Med       Date:  2010-09-23       Impact factor: 91.245
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Review 2.  Physiology and its importance for reference intervals.

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Review 3.  Biomarkers for Diagnosis and Prognosis of AKI in Children: One Size Does Not Fit All.

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Review 4.  Pharmacogenetics: can genes determine treatment efficacy and safety in JIA?

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5.  Serum protein profiling of adults and children with Crohn disease.

Authors:  Anna Vaiopoulou; Maria Gazouli; Aggeliki Papadopoulou; Athanassios K Anagnostopoulos; George Karamanolis; George E Theodoropoulos; Amosy M'Koma; George T Tsangaris
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Review 6.  Pediatric Clinical Endpoint and Pharmacodynamic Biomarkers: Limitations and Opportunities.

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Review 7.  Biomarkers for CNS involvement in pediatric lupus.

Authors:  Tamar B Rubinstein; Chaim Putterman; Beatrice Goilav
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Review 8.  Advances in biomarkers for paediatric rheumatic diseases.

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9.  Biomarkers improve prediction of 30-day unplanned readmission or mortality after paediatric congenital heart surgery.

Authors:  Jeremiah R Brown; Meagan E Stabler; Devin M Parker; Luca Vricella; Sara Pasquali; JoAnna K Leyenaar; Andrew R Bohm; Todd MacKenzie; Chirag Parikh; Marshall L Jacobs; Jeffrey P Jacobs; Allen D Everett
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10.  Reference intervals for urinary renal injury biomarkers KIM-1 and NGAL in healthy children.

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