Literature DB >> 21137032

Biomarkers in pediatrics: children as biomarker orphans.

William J Savage1, Allen D Everett.   

Abstract

Biomarkers have enormous potential to improve patient care by establishing tests of diagnosis, prognosis, and treatment effects. Successfully translating a biomarker from discovery to clinical application demands high-quality discovery research and high-quality clinical studies for biomarker validation; however, there are additional challenges that face biomarker research in pediatrics. There are also additional characteristics of pediatric medicine that make biomarker research especially needed. This review focuses on the fundamentals of biomarkers, the additional considerations needed for applying biomarker research to children, and recommendations for advancing pediatric biomarker research.
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2010        PMID： 21137032     DOI： 10.1002/prca.201000062

Source DB:  PubMed          Journal:  Proteomics Clin Appl        ISSN： 1862-8346            Impact factor:   3.494


  13 in total

Review 1.  Development of Drug Therapies for Newborns and Children: The Scientific and Regulatory Imperatives.

Authors:  Yeruk Lily Mulugeta; Anne Zajicek; Jeff Barrett; Hari Cheryl Sachs; Susan McCune; Vikram Sinha; Lynne Yao
Journal:  Pediatr Clin North Am       Date:  2017-12       Impact factor: 3.278

Review 2.  Proteomic and biomarker studies and neurological complications of pediatric sickle cell disease.

Authors:  Eboni I Lance; James F Casella; Allen D Everett; Emily Barron-Casella
Journal:  Proteomics Clin Appl       Date:  2014-11-06       Impact factor: 3.494

3.  Biomarkers for severity of neonatal hypoxic-ischemic encephalopathy and outcomes in newborns receiving hypothermia therapy.

Authors:  Lina F Chalak; Pablo J Sánchez; Beverley Adams-Huet; Abbot R Laptook; Roy J Heyne; Charles R Rosenfeld
Journal:  J Pediatr       Date:  2013-12-12       Impact factor: 4.406

Review 4.  Development of biomarkers to optimize pediatric patient management: what makes children different?

Authors:  Jennifer Goldman; Mara L Becker; Bridgette Jones; Mark Clements; J Steven Leeder
Journal:  Biomark Med       Date:  2011-12       Impact factor: 2.851

5.  Children as Biomarker Orphans: Progress in the Field of Pediatric Biomarkers.

Authors:  Darla R Shores; Allen D Everett
Journal:  J Pediatr       Date:  2017-10-12       Impact factor: 4.406

6.  Urinary biomarkers and acute kidney injury in children: the long road to clinical application.

Authors:  Helmut Schiffl; Susanne M Lang
Journal:  Pediatr Nephrol       Date:  2013-03-19       Impact factor: 3.714

Review 7.  Clinical significance of serum biomarkers in pediatric solid mediastinal and abdominal tumors.

Authors:  John A Sandoval; Linda H Malkas; Robert J Hickey
Journal:  Int J Mol Sci       Date:  2012-01-20       Impact factor: 6.208

8.  An Integrated Transcriptomic Approach to Identify Molecular Markers of Calcineurin Inhibitor Nephrotoxicity in Pediatric Kidney Transplant Recipients.

Authors:  Erika T Rhone; Elissa Bardhi; Sai Vineela Bontha; Patrick D Walker; Jorge A Almenara; Catherine I Dumur; Helen Cathro; Daniel Maluf; Valeria Mas
Journal:  Int J Mol Sci       Date:  2021-05-21       Impact factor: 5.923

Review 9.  Innovative Study Designs Optimizing Clinical Pharmacology Research in Infants and Children.

Authors:  Stephen J Balevic; Michael Cohen-Wolkowiez
Journal:  J Clin Pharmacol       Date:  2018-10       Impact factor: 2.860

Review 10.  The proteomics of lung injury in childhood: challenges and opportunities.

Authors:  Prue M Pereira-Fantini; David G Tingay
Journal:  Clin Proteomics       Date:  2016-02-29       Impact factor: 3.988
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