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Literature DB >> 22083793

Shadow enhancers: frequently asked questions about distributed cis-regulatory information and enhancer redundancy.

Abstract

This paper, in the form of a frequently asked questions page (FAQ), addresses outstanding questions about "shadow enhancers", quasi-redundant cis-regulatory elements, and their proposed roles in transcriptional control. Questions include: What exactly are shadow enhancers? How many genes have shadow/redundant/distributed enhancers? How redundant are these elements? What is the function of distributed enhancers? How modular are enhancers? Is it useful to study a single enhancer in isolation? In addition, a revised definition of "shadow enhancers" is proposed, and possible mechanisms of shadow enhancer function and evolution are discussed.

Entities: Disease Gene Species

Mesh：

Year: 2011 PMID： 22083793 PMCID： PMC3517143 DOI： 10.1002/bies.201100121

Source DB: PubMed Journal: Bioessays ISSN： 0265-9247 Impact factor: 4.345

88 in total

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