Literature DB >> 9671692

Evolvability.

M Kirschner1, J Gerhart.   

Abstract

Evolvability is an organism's capacity to generate heritable phenotypic variation. Metazoan evolution is marked by great morphological and physiological diversification, although the core genetic, cell biological, and developmental processes are largely conserved. Metazoan diversification has entailed the evolution of various regulatory processes controlling the time, place, and conditions of use of the conserved core processes. These regulatory processes, and certain of the core processes, have special properties relevant to evolutionary change. The properties of versatile protein elements, weak linkage, compartmentation, redundancy, and exploratory behavior reduce the interdependence of components and confer robustness and flexibility on processes during embryonic development and in adult physiology. They also confer evolvability on the organism by reducing constraints on change and allowing the accumulation of nonlethal variation. Evolvability may have been generally selected in the course of selection for robust, flexible processes suitable for complex development and physiology and specifically selected in lineages undergoing repeated radiations.

Mesh:

Year:  1998        PMID: 9671692      PMCID: PMC33871          DOI: 10.1073/pnas.95.15.8420

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


  12 in total

1.  The geometry of evolution.

Authors:  M Conrad
Journal:  Biosystems       Date:  1990       Impact factor: 1.973

Review 2.  Beyond self-assembly: from microtubules to morphogenesis.

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Review 3.  Early stages of chick somite development.

Authors:  B Christ; C P Ordahl
Journal:  Anat Embryol (Berl)       Date:  1995-05

Review 4.  bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out.

Authors:  E N Olson; W H Klein
Journal:  Genes Dev       Date:  1994-01       Impact factor: 11.361

Review 5.  Developmental evolution: insights from studies of insect segmentation.

Authors:  N H Patel
Journal:  Science       Date:  1994-10-28       Impact factor: 47.728

Review 6.  Joining the complex: cyclin-dependent kinase inhibitory proteins and the cell cycle.

Authors:  M Peter; I Herskowitz
Journal:  Cell       Date:  1994-10-21       Impact factor: 41.582

Review 7.  The achaete-scute complex: generation of cellular pattern and fate within the Drosophila nervous system.

Authors:  J B Skeath; S B Carroll
Journal:  FASEB J       Date:  1994-07       Impact factor: 5.191

8.  Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.

Authors:  W E Meador; A R Means; F A Quiocho
Journal:  Science       Date:  1993-12-10       Impact factor: 47.728

Review 9.  The multifunctional Ca2+/calmodulin-dependent protein kinases.

Authors:  H Schulman
Journal:  Curr Opin Cell Biol       Date:  1993-04       Impact factor: 8.382

10.  Polyembryonic development: insect pattern formation in a cellularized environment.

Authors:  M Grbic; L M Nagy; S B Carroll; M Strand
Journal:  Development       Date:  1996-03       Impact factor: 6.868

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  308 in total

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Authors:  J Jernvall
Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-14       Impact factor: 11.205

Review 2.  Developmental mechanisms: putting genes in their place.

Authors:  Stuart A Newman
Journal:  J Biosci       Date:  2002-03       Impact factor: 1.826

3.  Mutation, specialization, and hypersensitivity in highly optimized tolerance.

Authors:  Tong Zhou; J M Carlson; John Doyle
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-12       Impact factor: 11.205

4.  Specificity determinants and diversification of the Brassica self-incompatibility pollen ligand.

Authors:  Thanat Chookajorn; Aardra Kachroo; Daniel R Ripoll; Andrew G Clark; June B Nasrallah
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-23       Impact factor: 11.205

5.  Organismal complexity, protein complexity, and gene duplicability.

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Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-05       Impact factor: 11.205

Review 6.  Dopamine receptors for every species: gene duplications and functional diversification in Craniates.

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Journal:  J Struct Funct Genomics       Date:  2003

7.  Quantitative trait symmetry independent of Hsp90 buffering: distinct modes of genetic canalization and developmental stability.

Authors:  Claire C Milton; Brandon Huynh; Philip Batterham; Suzanne L Rutherford; Ary A Hoffmann
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-31       Impact factor: 11.205

Review 8.  Eukaryotic cells and their cell bodies: Cell Theory revised.

Authors:  Frantisek Baluska; Dieter Volkmann; Peter W Barlow
Journal:  Ann Bot       Date:  2004-05-20       Impact factor: 4.357

9.  An ORFeome-based analysis of human transcription factor genes and the construction of a microarray to interrogate their expression.

Authors:  David N Messina; Jarret Glasscock; Warren Gish; Michael Lovett
Journal:  Genome Res       Date:  2004-10       Impact factor: 9.043

10.  The identities of sym-2, sym-3 and sym-4, three genes that are synthetically lethal with mec-8 in Caenorhabditis elegans.

Authors:  John Yochem; Leslie R Bell; Robert K Herman
Journal:  Genetics       Date:  2004-11       Impact factor: 4.562

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