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Literature DB >> 22081311

SOCS5 and SOCS6 have similar expression patterns in normal and cancer tissues.

Sungpil Yoon¹, Young-Su Yi, Sang Soo Kim, Ju-Hwa Kim, Won Sang Park, Suk Woo Nam.

Abstract

In the present study, we investigated mRNA expression patterns of both SOCS5 and SOCS6 in various normal and cancer tissues using a commercially available Cancer Profiling Array. We found that SOCS5 and SOCS6 had similar expression patterns in most cancer and healthy individuals, suggesting that these two genes are transcriptionally co-regulated. Tissue-specific up- or down-regulation of SOCS5 and SOCS6 was observed in several cancer tissues. Most importantly, thyroid gland cancer tissues exhibited large reductions of both SOCS5 and SOCS6 expressions. In addition, mRNA and protein levels of SOCS6 were down-regulated in liver cancer tissues. The results from our study may contribute to understanding SOCS5 and SOCS6 expression regulation in various cancer tissues, and show that these two factors may be used for diagnosing cancer.

Entities: Disease Gene

Mesh：

Substances：

Year: 2011 PMID： 22081311 DOI： 10.1007/s13277-011-0264-4

Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283

31 in total

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Journal: Mol Endocrinol Date: 2000-05

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14 in total

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Authors: Monique C Trengove; Alister C Ward
Journal: Am J Clin Exp Immunol Date: 2013-02-27

4. Inhibition of miR-1298-5p attenuates sepsis lung injury by targeting SOCS6.

Authors: Jian Ma; Li-Yun Xu; Qiu-Hong Sun; Xiao-Yu Wan
Journal: Mol Cell Biochem Date: 2021-06-07 Impact factor: 3.396

5. Reduced expression of SOCS2 and SOCS6 in hepatocellular carcinoma correlates with aggressive tumor progression and poor prognosis.

Authors: Xinyu Qiu; Jianyong Zheng; Xiaodong Guo; Xingchun Gao; Hui Liu; Yanyang Tu; Yongsheng Zhang
Journal: Mol Cell Biochem Date: 2013-03-11 Impact factor: 3.396