Literature DB >> 22078874

Feedback on fat: p62-mTORC1-autophagy connections.

Jorge Moscat1, Maria T Diaz-Meco.   

Abstract

Metabolic homeostasis requires integration of multiple signals and cellular activities. Without this integration, conditions of obesity and diabetes often develop. Recent in vivo studies explore the molecular basis for metabolic homestasis, showing that p62 links autophagy and mTORC1 activation to regulate adipogenesis and energy control.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 22078874      PMCID： PMC3290994          DOI： 10.1016/j.cell.2011.10.021

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  20 in total

1.  Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration.

Authors:  Pazit Polak; Nadine Cybulski; Jerome N Feige; Johan Auwerx; Markus A Rüegg; Michael N Hall
Journal:  Cell Metab       Date:  2008-11       Impact factor: 27.287

2.  p62 is a key regulator of nutrient sensing in the mTORC1 pathway.

Authors:  Angeles Duran; Ramars Amanchy; Juan F Linares; Jayashree Joshi; Shadi Abu-Baker; Aleksey Porollo; Malene Hansen; Jorge Moscat; Maria T Diaz-Meco
Journal:  Mol Cell       Date:  2011-10-07       Impact factor: 17.970

3.  Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

Authors:  Yasemin Sancak; Liron Bar-Peled; Roberto Zoncu; Andrew L Markhard; Shigeyuki Nada; David M Sabatini
Journal:  Cell       Date:  2010-04-08       Impact factor: 41.582

4.  Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy.

Authors:  C Florian Bentzinger; Klaas Romanino; Dimitri Cloëtta; Shuo Lin; Joseph B Mascarenhas; Filippo Oliveri; Jinyu Xia; Emilio Casanova; Céline F Costa; Marijke Brink; Francesco Zorzato; Michael N Hall; Markus A Rüegg
Journal:  Cell Metab       Date:  2008-11       Impact factor: 27.287

5.  Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity.

Authors:  Sung Hee Um; Francesca Frigerio; Mitsuhiro Watanabe; Frédéric Picard; Manel Joaquin; Melanie Sticker; Stefano Fumagalli; Peter R Allegrini; Sara C Kozma; Johan Auwerx; George Thomas
Journal:  Nature       Date:  2004-08-11       Impact factor: 49.962

Review 6.  Defining the role of mTOR in cancer.

Authors:  David A Guertin; David M Sabatini
Journal:  Cancer Cell       Date:  2007-07       Impact factor: 31.743

7.  Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis.

Authors:  Yong Zhang; Scott Goldman; Rebecca Baerga; Yun Zhao; Masaaki Komatsu; Shengkan Jin
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-12       Impact factor: 11.205

8.  mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex.

Authors:  John T Cunningham; Joseph T Rodgers; Daniel H Arlow; Francisca Vazquez; Vamsi K Mootha; Pere Puigserver
Journal:  Nature       Date:  2007-11-29       Impact factor: 49.962

Review 9.  p62 at the crossroads of autophagy, apoptosis, and cancer.

Authors:  Jorge Moscat; Maria T Diaz-Meco
Journal:  Cell       Date:  2009-06-12       Impact factor: 41.582

10.  Termination of autophagy and reformation of lysosomes regulated by mTOR.

Authors:  Li Yu; Christina K McPhee; Lixin Zheng; Gonzalo A Mardones; Yueguang Rong; Junya Peng; Na Mi; Ying Zhao; Zhihua Liu; Fengyi Wan; Dale W Hailey; Viola Oorschot; Judith Klumperman; Eric H Baehrecke; Michael J Lenardo
Journal:  Nature       Date:  2010-06-06       Impact factor: 49.962
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  72 in total

1.  Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade.

Authors:  Juan F Linares; Angeles Duran; Miguel Reina-Campos; Pedro Aza-Blanc; Alex Campos; Jorge Moscat; Maria T Diaz-Meco
Journal:  Cell Rep       Date:  2015-08-13       Impact factor: 9.423

2.  Autophagy-mediated Mir6981 degradation exhibits CDKN1B promotion of PHLPP1 protein translation.

Authors:  Minggang Peng; Jingjing Wang; Zhongxian Tian; Dongyun Zhang; Honglei Jin; Claire Liu; Jiawei Xu; Jingxia Li; Xiaohui Hua; Jiheng Xu; Chao Huang; Chuanshu Huang
Journal:  Autophagy       Date:  2019-03-08       Impact factor: 16.016

Review 3.  p62: a versatile multitasker takes on cancer.

Authors:  Jorge Moscat; Maria T Diaz-Meco
Journal:  Trends Biochem Sci       Date:  2012-03-15       Impact factor: 13.807

4.  Suppression of myopathic lamin mutations by muscle-specific activation of AMPK and modulation of downstream signaling.

Authors:  Sahaana Chandran; Jennifer A Suggs; Bingyan J Wang; Andrew Han; Shruti Bhide; Diane E Cryderman; Steven A Moore; Sanford I Bernstein; Lori L Wallrath; Girish C Melkani
Journal:  Hum Mol Genet       Date:  2019-02-01       Impact factor: 6.150

Review 5.  p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer.

Authors:  Koji Taniguchi; Shinichiro Yamachika; Feng He; Michael Karin
Journal:  FEBS Lett       Date:  2016-08-06       Impact factor: 4.124

6.  Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α.

Authors:  Bo-Jhih Guan; Dawid Krokowski; Mithu Majumder; Christine L Schmotzer; Scot R Kimball; William C Merrick; Antonis E Koromilas; Maria Hatzoglou
Journal:  J Biol Chem       Date:  2014-03-19       Impact factor: 5.157

7.  Lipid droplet and early autophagosomal membrane targeting of Atg2A and Atg14L in human tumor cells.

Authors:  Simon G Pfisterer; Daniela Bakula; Tancred Frickey; Alice Cezanne; Daniel Brigger; Mario P Tschan; Horst Robenek; Tassula Proikas-Cezanne
Journal:  J Lipid Res       Date:  2014-04-28       Impact factor: 5.922

8.  PHF23 (plant homeodomain finger protein 23) negatively regulates cell autophagy by promoting ubiquitination and degradation of E3 ligase LRSAM1.

Authors:  Zhenda Wang; Jia Hu; Ge Li; Liujing Qu; Qihua He; Yaxin Lou; Quansheng Song; Dalong Ma; Yingyu Chen
Journal:  Autophagy       Date:  2014       Impact factor: 16.016

9.  p62 links β-adrenergic input to mitochondrial function and thermogenesis.

Authors:  Timo D Müller; Sang Jun Lee; Martin Jastroch; Dhiraj Kabra; Kerstin Stemmer; Michaela Aichler; Bill Abplanalp; Gayathri Ananthakrishnan; Nakul Bhardwaj; Sheila Collins; Senad Divanovic; Max Endele; Brian Finan; Yuanqing Gao; Kirk M Habegger; Jazzmin Hembree; Kristy M Heppner; Susanna Hofmann; Jenna Holland; Daniela Küchler; Maria Kutschke; Radha Krishna; Maarit Lehti; Rebecca Oelkrug; Nickki Ottaway; Diego Perez-Tilve; Christine Raver; Axel K Walch; Sonja C Schriever; John Speakman; Yu-Hua Tseng; Maria Diaz-Meco; Paul T Pfluger; Jorge Moscat; Matthias H Tschöp
Journal:  J Clin Invest       Date:  2012-12-21       Impact factor: 14.808

10.  DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating Autophagy via Interaction with p62/SQSTM1.

Authors:  Hao Zhang; Yanqiu Zhang; Xiaoyun Zhu; Chen Chen; Chao Zhang; Yuanzheng Xia; Yucheng Zhao; Ourania Andrisani; Lingyi Kong
Journal:  Hepatology       Date:  2019-02-08       Impact factor: 17.425
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