Literature DB >> 19524504

p62 at the crossroads of autophagy, apoptosis, and cancer.

Jorge Moscat1, Maria T Diaz-Meco.   

Abstract

The signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor NF-kappaB. Recent findings link p62 activity to the extrinsic apoptosis pathway, and Mathew et al. (2009) now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. These findings place p62 at critical decision points that control cell death and survival.

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Year:  2009        PMID： 19524504      PMCID： PMC3971861          DOI： 10.1016/j.cell.2009.05.023

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  20 in total

1.  Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.

Authors:  Masaaki Komatsu; Satoshi Waguri; Masato Koike; Yu-Shin Sou; Takashi Ueno; Taichi Hara; Noboru Mizushima; Jun-Ichi Iwata; Junji Ezaki; Shigeo Murata; Jun Hamazaki; Yasumasa Nishito; Shun-Ichiro Iemura; Tohru Natsume; Toru Yanagawa; Junya Uwayama; Eiji Warabi; Hiroshi Yoshida; Tetsuro Ishii; Akira Kobayashi; Masayuki Yamamoto; Zhenyu Yue; Yasuo Uchiyama; Eiki Kominami; Keiji Tanaka
Journal:  Cell       Date:  2007-12-14       Impact factor: 41.582

2.  Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.

Authors:  Angelina Rodriguez; Angeles Durán; Mohammed Selloum; Marie-France Champy; Francisco J Diez-Guerra; Juana María Flores; Manuel Serrano; Johan Auwerx; María T Diaz-Meco; Jorge Moscat
Journal:  Cell Metab       Date:  2006-03       Impact factor: 27.287

3.  A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.

Authors:  Vladimir Kirkin; Trond Lamark; Yu-Shin Sou; Geir Bjørkøy; Jennifer L Nunn; Jack-Ansgar Bruun; Elena Shvets; David G McEwan; Terje H Clausen; Philipp Wild; Ivana Bilusic; Jean-Philippe Theurillat; Aud Øvervatn; Tetsuro Ishii; Zvulun Elazar; Masaaki Komatsu; Ivan Dikic; Terje Johansen
Journal:  Mol Cell       Date:  2009-02-27       Impact factor: 17.970

Review 4.  Signal integration and diversification through the p62 scaffold protein.

Authors:  Jorge Moscat; María T Diaz-Meco; Marie W Wooten
Journal:  Trends Biochem Sci       Date:  2006-12-15       Impact factor: 13.807

5.  Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling.

Authors:  Thangiah Geetha; Jianxiong Jiang; Marie W Wooten
Journal:  Mol Cell       Date:  2005-10-28       Impact factor: 17.970

6.  Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone.

Authors:  Nancy Laurin; Jacques P Brown; Jean Morissette; Vincent Raymond
Journal:  Am J Hum Genet       Date:  2002-04-30       Impact factor: 11.025

7.  Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes.

Authors:  Peter Kijun Kim; Dale Warren Hailey; Robert Thomas Mullen; Jennifer Lippincott-Schwartz
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-12       Impact factor: 11.205

8.  A SQSTM1/p62 mutation linked to Paget's disease increases the osteoclastogenic potential of the bone microenvironment.

Authors:  Yuko Hiruma; Noriyoshi Kurihara; Mark A Subler; Hua Zhou; Christina S Boykin; Heju Zhang; Seiichi Ishizuka; David W Dempster; G David Roodman; Jolene J Windle
Journal:  Hum Mol Genet       Date:  2008-09-02       Impact factor: 6.150

9.  p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.

Authors:  Serhiy Pankiv; Terje Høyvarde Clausen; Trond Lamark; Andreas Brech; Jack-Ansgar Bruun; Heidi Outzen; Aud Øvervatn; Geir Bjørkøy; Terje Johansen
Journal:  J Biol Chem       Date:  2007-06-19       Impact factor: 5.157

10.  The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis.

Authors:  Angeles Duran; Juan F Linares; Anita S Galvez; Kathryn Wikenheiser; Juana M Flores; Maria T Diaz-Meco; Jorge Moscat
Journal:  Cancer Cell       Date:  2008-04       Impact factor: 31.743
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  472 in total

1.  p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.

Authors:  Ashish Jain; Trond Lamark; Eva Sjøttem; Kenneth Bowitz Larsen; Jane Atesoh Awuh; Aud Øvervatn; Michael McMahon; John D Hayes; Terje Johansen
Journal:  J Biol Chem       Date:  2010-05-07       Impact factor: 5.157

2.  Identification of an autophagy defect in smokers' alveolar macrophages.

Authors:  Martha M Monick; Linda S Powers; Katherine Walters; Nina Lovan; Michael Zhang; Alicia Gerke; Sif Hansdottir; Gary W Hunninghake
Journal:  J Immunol       Date:  2010-10-04       Impact factor: 5.422

3.  Autophagy suppresses interleukin-1β (IL-1β) signaling by activation of p62 degradation via lysosomal and proteasomal pathways.

Authors:  Jongdae Lee; Hye Ri Kim; Christine Quinley; Joanna Kim; Jose Gonzalez-Navajas; Ramnik Xavier; Eyal Raz
Journal:  J Biol Chem       Date:  2011-12-13       Impact factor: 5.157

Review 4.  Feedback on fat: p62-mTORC1-autophagy connections.

Authors:  Jorge Moscat; Maria T Diaz-Meco
Journal:  Cell       Date:  2011-11-11       Impact factor: 41.582

5.  Drosophila Golgi membrane protein Ema promotes autophagosomal growth and function.

Authors:  Sungsu Kim; Sarah A Naylor; Aaron DiAntonio
Journal:  Proc Natl Acad Sci U S A       Date:  2012-04-09       Impact factor: 11.205

6.  Transient aggregation of ubiquitinated proteins is a cytosolic unfolded protein response to inflammation and endoplasmic reticulum stress.

Authors:  Xian-De Liu; Soyoung Ko; Yi Xu; Elmoataz Abdel Fattah; Qian Xiang; Chinnaswamy Jagannath; Tetsuro Ishii; Masaaki Komatsu; N Tony Eissa
Journal:  J Biol Chem       Date:  2012-04-19       Impact factor: 5.157

Review 7.  Regulation of autophagy and mitophagy by nutrient availability and acetylation.

Authors:  Bradley R Webster; Iain Scott; Javier Traba; Kim Han; Michael N Sack
Journal:  Biochim Biophys Acta       Date:  2014-02-11

8.  Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation.

Authors:  Eliseo F Castillo; Alexander Dekonenko; John Arko-Mensah; Michael A Mandell; Nicolas Dupont; Shanya Jiang; Monica Delgado-Vargas; Graham S Timmins; Dhruva Bhattacharya; Hongliang Yang; Julie Hutt; C Rick Lyons; Karen M Dobos; Vojo Deretic
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-23       Impact factor: 11.205

9.  Sequestosome 1 protects esophageal squamous carcinoma cells from apoptosis via stabilizing SKP2 under serum starvation condition.

Authors:  Chao Shi; Bei-Qing Pan; Feng Shi; Zhi-Hui Xie; Yan-Yi Jiang; Li Shang; Yu Zhang; Xin Xu; Yan Cai; Jia-Jie Hao; Ming-Rong Wang
Journal:  Oncogene       Date:  2018-03-19       Impact factor: 9.867

Review 10.  p62 Stages an interplay between the ubiquitin-proteasome system and autophagy in the heart of defense against proteotoxic stress.

Authors:  Huabo Su; Xuejun Wang
Journal:  Trends Cardiovasc Med       Date:  2011-11       Impact factor: 6.677
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