| Literature DB >> 22076380 |
Abimael Cruz-Migoni1, Guillaume M Hautbergue, Peter J Artymiuk, Patrick J Baker, Monika Bokori-Brown, Chung-Te Chang, Mark J Dickman, Angela Essex-Lopresti, Sarah V Harding, Nor Muhammad Mahadi, Laura E Marshall, George W Mobbs, Rahmah Mohamed, Sheila Nathan, Sarah A Ngugi, Catherine Ong, Wen Fong Ooi, Lynda J Partridge, Helen L Phillips, M Firdaus Raih, Sergei Ruzheinikov, Mitali Sarkar-Tyson, Svetlana E Sedelnikova, Sophie J Smither, Patrick Tan, Richard W Titball, Stuart A Wilson, David W Rice.
Abstract
The structure of BPSL1549, a protein of unknown function from Burkholderia pseudomallei, reveals a similarity to Escherichia coli cytotoxic necrotizing factor 1. We found that BPSL1549 acted as a potent cytotoxin against eukaryotic cells and was lethal when administered to mice. Expression levels of bpsl1549 correlate with conditions expected to promote or suppress pathogenicity. BPSL1549 promotes deamidation of glutamine-339 of the translation initiation factor eIF4A, abolishing its helicase activity and inhibiting translation. We propose to name BPSL1549 Burkholderia lethal factor 1.Entities:
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Year: 2011 PMID： 22076380 PMCID： PMC3364511 DOI： 10.1126/science.1211915
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728