Literature DB >> 22072754

Structural map of a microRNA-122: hepatitis C virus complex.

Phillip S Pang1, Edward A Pham, Menashe Elazar, Shripa G Patel, Michael R Eckart, Jeffrey S Glenn.   

Abstract

MicroRNA-122 (miR-122) enhances hepatitis C virus (HCV) fitness via targeting two sites in the 5'-untranslated region (UTR) of HCV. We used selective 2'-hydroxyl acylation analyzed by primer extension to resolve the HCV 5'-UTR's RNA secondary structure in the presence of miR-122. Nearly all nucleotides in miR-122 are involved in targeting the second site, beyond classic seed base pairings. These additional interactions enhance HCV replication in cell culture. To our knowledge, this is the first biophysical study of this complex to reveal the importance of 'tail' miR-122 nucleotide interactions.

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Year:  2011        PMID： 22072754      PMCID： PMC3255806          DOI： 10.1128/JVI.06367-11

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  23 in total

1.  RnaViz 2: an improved representation of RNA secondary structure.

Authors:  Peter De Rijk; Jan Wuyts; Rupert De Wachter
Journal:  Bioinformatics       Date:  2003-01-22       Impact factor: 6.937

2.  WebLogo: a sequence logo generator.

Authors:  Gavin E Crooks; Gary Hon; John-Marc Chandonia; Steven E Brenner
Journal:  Genome Res       Date:  2004-06       Impact factor: 9.043

3.  RNA structure analysis at single nucleotide resolution by selective 2'-hydroxyl acylation and primer extension (SHAPE).

Authors:  Edward J Merino; Kevin A Wilkinson; Jennifer L Coughlan; Kevin M Weeks
Journal:  J Am Chem Soc       Date:  2005-03-30       Impact factor: 15.419

4.  Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA.

Authors:  Catherine L Jopling; Minkyung Yi; Alissa M Lancaster; Stanley M Lemon; Peter Sarnow
Journal:  Science       Date:  2005-09-02       Impact factor: 47.728

5.  Selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE): quantitative RNA structure analysis at single nucleotide resolution.

Authors:  Kevin A Wilkinson; Edward J Merino; Kevin M Weeks
Journal:  Nat Protoc       Date:  2006       Impact factor: 13.491

6.  MicroRNA targeting specificity in mammals: determinants beyond seed pairing.

Authors:  Andrew Grimson; Kyle Kai-How Farh; Wendy K Johnston; Philip Garrett-Engele; Lee P Lim; David P Bartel
Journal:  Mol Cell       Date:  2007-07-06       Impact factor: 17.970

Review 7.  Site-specific RNA crosslinking with 4-thiouridine.

Authors:  E J Sontheimer
Journal:  Mol Biol Rep       Date:  1994-07       Impact factor: 2.316

8.  Measurement of DNA length by gel electrophoresis.

Authors:  E M Southern
Journal:  Anal Biochem       Date:  1979-12       Impact factor: 3.365

9.  The hepatitis C virus internal ribosome entry site adopts an ion-dependent tertiary fold.

Authors:  J S Kieft; K Zhou; R Jubin; M G Murray; J Y Lau; J A Doudna
Journal:  J Mol Biol       Date:  1999-09-24       Impact factor: 5.469

10.  Masking the 5' terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex.

Authors:  Erica S Machlin; Peter Sarnow; Selena M Sagan
Journal:  Proc Natl Acad Sci U S A       Date:  2011-01-10       Impact factor: 11.205
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  13 in total

1.  Base pairing between hepatitis C virus RNA and microRNA 122 3' of its seed sequence is essential for genome stabilization and production of infectious virus.

Authors:  Tetsuro Shimakami; Daisuke Yamane; Christoph Welsch; Lucinda Hensley; Rohit K Jangra; Stanley M Lemon
Journal:  J Virol       Date:  2012-04-24       Impact factor: 5.103

2.  miR-122 and Ago interactions with the HCV genome alter the structure of the viral 5' terminus.

Authors:  Jasmin Chahal; Luca F R Gebert; Hin Hark Gan; Edna Camacho; Kristin C Gunsalus; Ian J MacRae; Selena M Sagan
Journal:  Nucleic Acids Res       Date:  2019-06-04       Impact factor: 16.971

Review 3.  MiR-122 in hepatic function and liver diseases.

Authors:  Jun Hu; Yaxing Xu; Junli Hao; Saifeng Wang; Changfei Li; Songdong Meng
Journal:  Protein Cell       Date:  2012-05-18       Impact factor: 14.870

4.  Programmable antivirals targeting critical conserved viral RNA secondary structures from influenza A virus and SARS-CoV-2.

Authors:  Rachel J Hagey; Menashe Elazar; Edward A Pham; Siqi Tian; Lily Ben-Avi; Claire Bernardin-Souibgui; Matthew F Yee; Fernando R Moreira; Meirav Vilan Rabinovitch; Rita M Meganck; Benjamin Fram; Aimee Beck; Scott A Gibson; Grace Lam; Josephine Devera; Wipapat Kladwang; Khanh Nguyen; Anming Xiong; Steven Schaffert; Talia Avisar; Ping Liu; Arjun Rustagi; Carl J Fichtenbaum; Phillip S Pang; Purvesh Khatri; Chien-Te Tseng; Jeffery K Taubenberger; Catherine A Blish; Brett L Hurst; Timothy P Sheahan; Rhiju Das; Jeffrey S Glenn
Journal:  Nat Med       Date:  2022-08-18       Impact factor: 87.241

Review 5.  Functional RNA structures throughout the Hepatitis C Virus genome.

Authors:  Rebecca L Adams; Nathan Pirakitikulr; Anna Marie Pyle
Journal:  Curr Opin Virol       Date:  2017-05-13       Impact factor: 7.090

6.  Hepatitis C virus RNA functionally sequesters miR-122.

Authors:  Joseph M Luna; Troels K H Scheel; Tal Danino; Katharina S Shaw; Aldo Mele; John J Fak; Eiko Nishiuchi; Constantin N Takacs; Maria Teresa Catanese; Ype P de Jong; Ira M Jacobson; Charles M Rice; Robert B Darnell
Journal:  Cell       Date:  2015-03-12       Impact factor: 41.582

Review 7.  The yin and yang of hepatitis C: synthesis and decay of hepatitis C virus RNA.

Authors:  You Li; Daisuke Yamane; Takahiro Masaki; Stanley M Lemon
Journal:  Nat Rev Microbiol       Date:  2015-08-10       Impact factor: 60.633

Review 8.  Complex interactions between microRNAs and hepatitis B/C viruses.

Authors:  Hong-Xia Fan; Hua Tang
Journal:  World J Gastroenterol       Date:  2014-10-07       Impact factor: 5.742

9.  Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure.

Authors:  Stefanie A Mortimer; Jennifer A Doudna
Journal:  Nucleic Acids Res       Date:  2013-02-14       Impact factor: 16.971

Review 10.  Competitive virus and host RNAs: the interplay of a hidden virus and host interaction.

Authors:  Changfei Li; Jun Hu; Junli Hao; Bao Zhao; Bo Wu; Lu Sun; Shanxin Peng; George F Gao; Songdong Meng
Journal:  Protein Cell       Date:  2014-04-12       Impact factor: 14.870
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