PURPOSE: To evaluate short-term clinical and MRI outcome of the second generation characterized chondrocyte implantation (CCI) for the treatment of cartilage defects in the knee. METHODS: Thirty-two patients aged 15-51 years with single International Cartilage Repair Society (ICRS) grade III/IV symptomatic cartilage defects of different locations in the knee were treated with CCI using a synthetic collagen I/III membrane to cover the defect. Clinical outcome was measured over 36 months by the Knee injury and Osteoarthritis Outcome Score (KOOS) and Visual Analogue Scale (VAS) for pain. Serial magnetic resonance imaging (MRI) scans of 22 patients were scored using the original and modified Magnetic resonance Observation of Cartilage Repair Tissue (MOCART) system. RESULTS: The patients included in this study showed a significant gradual clinical improvement after CCI. The MRI findings of this pilot study were considered to be promising. No signs of deterioration were observed. A complete or hypertrophic filling was observed in 76.5% of the cases at 24 months of follow-up. No preventive effect of an avital membrane on the occurrence of hypertrophic repair tissue was observed on MRI. Three failures were observed among the 32 patients until now (9.4%). CONCLUSIONS: This investigation provided useful information on the efficacy of this treatment. The short-term clinical and MRI outcome are promising. Large-scale and long-term trials are mandatory to confirm the results and the reliability of this procedure. LEVEL OF EVIDENCE: IV.
PURPOSE: To evaluate short-term clinical and MRI outcome of the second generation characterized chondrocyte implantation (CCI) for the treatment of cartilage defects in the knee. METHODS: Thirty-two patients aged 15-51 years with single International Cartilage Repair Society (ICRS) grade III/IV symptomatic cartilage defects of different locations in the knee were treated with CCI using a synthetic collagen I/III membrane to cover the defect. Clinical outcome was measured over 36 months by the Knee injury and Osteoarthritis Outcome Score (KOOS) and Visual Analogue Scale (VAS) for pain. Serial magnetic resonance imaging (MRI) scans of 22 patients were scored using the original and modified Magnetic resonance Observation of Cartilage Repair Tissue (MOCART) system. RESULTS: The patients included in this study showed a significant gradual clinical improvement after CCI. The MRI findings of this pilot study were considered to be promising. No signs of deterioration were observed. A complete or hypertrophic filling was observed in 76.5% of the cases at 24 months of follow-up. No preventive effect of an avital membrane on the occurrence of hypertrophic repair tissue was observed on MRI. Three failures were observed among the 32 patients until now (9.4%). CONCLUSIONS: This investigation provided useful information on the efficacy of this treatment. The short-term clinical and MRI outcome are promising. Large-scale and long-term trials are mandatory to confirm the results and the reliability of this procedure. LEVEL OF EVIDENCE: IV.
Authors: Douglas L Cerynik; Gabriel E Lewullis; Brian C Joves; Michael P Palmer; James A Tom Journal: Knee Surg Sports Traumatol Arthrosc Date: 2009-03-19 Impact factor: 4.342
Authors: Philipp Niemeyer; Jan M Pestka; Peter C Kreuz; Christoph Erggelet; Hagen Schmal; Norbert P Suedkamp; Matthias Steinwachs Journal: Am J Sports Med Date: 2008-09-18 Impact factor: 6.202
Authors: Stefan Marlovits; Philip Zeller; Philipp Singer; Christoph Resinger; Vilmos Vécsei Journal: Eur J Radiol Date: 2005-09-26 Impact factor: 3.528
Authors: Elizaveta Kon; Marco Delcogliano; Giuseppe Filardo; Maurizio Busacca; Alessandro Di Martino; Maurilio Marcacci Journal: Am J Sports Med Date: 2011-02-10 Impact factor: 6.202
Authors: Aad Alfons Maria Dhollander; Karl Fredrik Almqvist; Kris Moens; Pieter-Jan Vandekerckhove; René Verdonk; Peter Verdonk; Jan Victor Journal: Knee Surg Sports Traumatol Arthrosc Date: 2014-04-22 Impact factor: 4.342
Authors: Thomas R Niethammer; Matthias F Pietschmann; Annie Horng; Björn P Roßbach; Andreas Ficklscherer; Volkmar Jansson; Peter E Müller Journal: Knee Surg Sports Traumatol Arthrosc Date: 2013-03-01 Impact factor: 4.342
Authors: Ayoosh Pareek; James L Carey; Patrick J Reardon; Lars Peterson; Michael J Stuart; Aaron J Krych Journal: Cartilage Date: 2016-03-03 Impact factor: 4.634
Authors: Jennifer S Howard; Carl G Mattacola; David R Mullineaux; Robert A English; Christian Lattermann Journal: Knee Surg Sports Traumatol Arthrosc Date: 2013-09-06 Impact factor: 4.342
Authors: Marco Delcogliano; Francesca de Caro; Edoardo Scaravella; Giovanni Ziveri; Carlo Felice De Biase; Domenico Marotta; Pietro Marenghi; Antonio Delcogliano Journal: Knee Surg Sports Traumatol Arthrosc Date: 2013-10-22 Impact factor: 4.342