N-Benzyl-1,3-dide-oxy-1,3-imino-l-xylitol.

The structure determination confirms the stereochemistry of the title compound, C(12)H(17)NO(3), which contains a four-membered azetidine ring system. The absolute configuration was determined by the use of d-glucose as the starting material. In the crystal, O-H⋯O and O-H⋯N hydrogen bonds link the mol-ecules into layers in the ab plane.

Related literature

For related literature on azetidines, see: Krämer et al. (1997 ▶); Michaud et al. (1997a ▶,b ▶); Dekaris & Reissig (2010 ▶); Soengas et al. (2011 ▶). For related literature on imino­sugars, see: Asano et al. (2000 ▶); Watson et al. (2001 ▶). For details of the cryostat, see: Cosier & Glazer (1986 ▶).

Experimental

Crystal data

C12H17NO3

M = 223.27

Orthorhombic,

a = 6.2309 (2) Å

b = 9.3918 (4) Å

c = 19.9175 (9) Å

V = 1165.56 (8) Å3

Z = 4

Mo Kα radiation

μ = 0.09 mm−1

T = 150 K

0.20 × 0.10 × 0.07 mm

Data collection

Nonius KappaCCD diffractometer

Absorption correction: multi-scan (DENZO/SCALEPACK; Otwinowski & Minor, 1997 ▶) T min = 0.97, T max = 0.99

6149 measured reflections

1541 independent reflections

1098 reflections with I > 2σ(I)

R int = 0.065

Refinement

R[F 2 > 2σ(F 2)] = 0.045

wR(F 2) = 0.102

S = 0.95

1541 reflections

146 parameters

H-atom parameters constrained

Δρmax = 0.49 e Å−3

Δρmin = −0.49 e Å−3

Data collection: COLLECT (Nonius, 2001 ▶); cell refinement: DENZO/SCALEPACK (Otwinowski & Minor, 1997 ▶); data reduction: DENZO/SCALEPACK; program(s) used to solve structure: SIR92 (Altomare et al., 1994 ▶); program(s) used to refine structure: CRYSTALS (Betteridge et al., 2003 ▶); molecular graphics: CAMERON (Watkin et al., 1996 ▶); software used to prepare material for publication: CRYSTALS.

Crystal structure: contains datablock(s) global, I. DOI: 10.1107/S160053681103399X/lh5318sup1.cif

Structure factors: contains datablock(s) I. DOI: 10.1107/S160053681103399X/lh5318Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

C12H17NO3	F(000) = 480
Mr = 223.27	Dx = 1.272 Mg m−3
Orthorhombic, P212121	Mo Kα radiation, λ = 0.71073 Å
Hall symbol: P 2ac 2ab	Cell parameters from 1467 reflections
a = 6.2309 (2) Å	θ = 5–27°
b = 9.3918 (4) Å	µ = 0.09 mm−1
c = 19.9175 (9) Å	T = 150 K
V = 1165.56 (8) Å3	Prism, colourless
Z = 4	0.20 × 0.10 × 0.07 mm

Nonius KappaCCD diffractometer	1098 reflections with I > 2σ(I)
graphite	Rint = 0.065
ω scans	θmax = 27.5°, θmin = 5.2°
Absorption correction: multi-scan (DENZO/SCALEPACK; Otwinowski & Minor, 1997)	h = −8→8
Tmin = 0.97, Tmax = 0.99	k = −12→12
6149 measured reflections	l = −25→25
1541 independent reflections

Refinement on F2	Hydrogen site location: inferred from neighbouring sites
Least-squares matrix: full	H-atom parameters constrained
R[F2 > 2σ(F2)] = 0.045	Method = modified Sheldrick, w = 1/[σ2(F2) + (0.05P)2 + 0.13P], where P = [max(Fo2,0) + 2Fc2]/3
wR(F2) = 0.102	(Δ/σ)max = 0.0002627
S = 0.95	Δρmax = 0.49 e Å−3
1541 reflections	Δρmin = −0.49 e Å−3
146 parameters	Extinction correction: Larson (1970), Equation 22
0 restraints	Extinction coefficient: 400 (70)
Primary atom site location: structure-invariant direct methods

Experimental. The crystal was placed in the cold stream of an Oxford Cryosystems open-flow nitrogen cryostat (Cosier & Glazer, 1986) with a nominal stability of 0.1 K.

	x	y	z	Uiso*/Ueq
O1	0.7910 (3)	0.89266 (18)	0.79718 (9)	0.0257
C2	0.8327 (4)	0.7498 (3)	0.81847 (12)	0.0246
C3	0.9587 (4)	0.6675 (3)	0.76640 (12)	0.0212
O4	1.1771 (3)	0.71531 (19)	0.75988 (9)	0.0261
C5	0.8472 (4)	0.6736 (3)	0.69895 (12)	0.0206
N6	0.9436 (3)	0.5853 (2)	0.64366 (9)	0.0198
C7	1.0678 (4)	0.6647 (3)	0.59325 (12)	0.0248
C8	1.1061 (4)	0.5768 (3)	0.53082 (12)	0.0252
C9	1.2467 (4)	0.4615 (3)	0.53077 (13)	0.0286
C10	1.2791 (5)	0.3829 (3)	0.47302 (15)	0.0384
C11	1.1727 (5)	0.4177 (3)	0.41474 (14)	0.0366
C12	1.0312 (5)	0.5309 (3)	0.41392 (14)	0.0373
C13	0.9984 (5)	0.6088 (3)	0.47187 (13)	0.0313
C14	0.7214 (4)	0.5438 (3)	0.62186 (13)	0.0277
C15	0.6349 (4)	0.5921 (3)	0.69017 (12)	0.0245
O16	0.6117 (3)	0.48138 (19)	0.73784 (9)	0.0277
H22	0.9101	0.7535	0.8624	0.0291*
H21	0.6964	0.7000	0.8265	0.0280*
H31	0.9716	0.5645	0.7806	0.0250*
H51	0.8349	0.7719	0.6843	0.0251*
H72	1.2057	0.6871	0.6139	0.0252*
H71	0.9916	0.7537	0.5814	0.0268*
H91	1.3207	0.4363	0.5701	0.0319*
H101	1.3719	0.3075	0.4739	0.0480*
H111	1.1995	0.3646	0.3761	0.0436*
H121	0.9557	0.5547	0.3747	0.0440*
H131	0.9009	0.6860	0.4710	0.0365*
H141	0.7104	0.4397	0.6145	0.0348*
H142	0.6670	0.5939	0.5830	0.0324*
H151	0.5114	0.6524	0.6881	0.0289*
H41	1.1628	0.8040	0.7623	0.0399*
H161	0.4864	0.4499	0.7314	0.0409*
H11	0.8789	0.9468	0.8187	0.0398*

	U11	U22	U33	U12	U13	U23
O1	0.0245 (9)	0.0213 (9)	0.0312 (9)	0.0011 (8)	−0.0042 (8)	−0.0039 (9)
C2	0.0288 (15)	0.0219 (14)	0.0231 (13)	−0.0006 (12)	−0.0021 (11)	0.0021 (11)
C3	0.0174 (12)	0.0210 (13)	0.0251 (13)	−0.0022 (11)	−0.0003 (11)	0.0004 (12)
O4	0.0193 (9)	0.0254 (10)	0.0336 (10)	0.0013 (8)	−0.0012 (8)	−0.0025 (9)
C5	0.0242 (13)	0.0189 (12)	0.0187 (11)	−0.0011 (11)	0.0015 (11)	−0.0004 (11)
N6	0.0205 (10)	0.0233 (11)	0.0157 (10)	−0.0008 (10)	−0.0005 (9)	−0.0030 (10)
C7	0.0226 (13)	0.0283 (15)	0.0236 (13)	−0.0042 (13)	0.0003 (12)	−0.0009 (12)
C8	0.0246 (14)	0.0304 (15)	0.0206 (12)	−0.0055 (13)	0.0004 (11)	0.0012 (12)
C9	0.0224 (13)	0.0402 (17)	0.0232 (13)	0.0039 (13)	0.0016 (12)	0.0029 (13)
C10	0.0325 (16)	0.0423 (18)	0.0404 (16)	0.0075 (15)	0.0068 (15)	−0.0048 (16)
C11	0.0372 (16)	0.0458 (19)	0.0267 (14)	0.0000 (16)	0.0051 (14)	−0.0056 (15)
C12	0.0399 (17)	0.0489 (19)	0.0232 (14)	−0.0010 (17)	−0.0029 (14)	−0.0025 (14)
C13	0.0350 (16)	0.0333 (16)	0.0256 (13)	0.0041 (14)	−0.0033 (12)	0.0017 (14)
C14	0.0212 (13)	0.0347 (16)	0.0273 (14)	−0.0005 (13)	−0.0055 (12)	−0.0009 (13)
C15	0.0174 (12)	0.0286 (15)	0.0275 (12)	0.0059 (12)	−0.0002 (11)	0.0017 (13)
O16	0.0215 (9)	0.0282 (10)	0.0335 (10)	−0.0042 (8)	−0.0010 (9)	0.0070 (9)

O1—C2	1.431 (3)	C8—C9	1.393 (4)
O1—H11	0.862	C8—C13	1.385 (4)
C2—C3	1.513 (3)	C9—C10	1.382 (4)
C2—H22	1.000	C9—H91	0.939
C2—H21	0.982	C10—C11	1.376 (4)
C3—O4	1.439 (3)	C10—H101	0.914
C3—C5	1.514 (3)	C11—C12	1.381 (4)
C3—H31	1.011	C11—H111	0.932
O4—H41	0.839	C12—C13	1.382 (4)
C5—N6	1.504 (3)	C12—H121	0.939
C5—C15	1.538 (3)	C13—H131	0.945
C5—H51	0.971	C14—C15	1.532 (3)
N6—C7	1.471 (3)	C14—H141	0.991
N6—C14	1.503 (3)	C14—H142	0.967
C7—C8	1.512 (3)	C15—O16	1.416 (3)
C7—H72	0.976	C15—H151	0.956
C7—H71	0.990	O16—H161	0.844
C2—O1—H11	106.9	C7—C8—C13	120.2 (2)
O1—C2—C3	111.7 (2)	C9—C8—C13	118.2 (2)
O1—C2—H22	108.3	C8—C9—C10	120.5 (3)
C3—C2—H22	111.6	C8—C9—H91	120.3
O1—C2—H21	109.7	C10—C9—H91	119.2
C3—C2—H21	108.5	C9—C10—C11	120.3 (3)
H22—C2—H21	106.9	C9—C10—H101	119.4
C2—C3—O4	113.2 (2)	C11—C10—H101	120.3
C2—C3—C5	110.5 (2)	C10—C11—C12	120.0 (3)
O4—C3—C5	110.0 (2)	C10—C11—H111	118.9
C2—C3—H31	109.8	C12—C11—H111	121.1
O4—C3—H31	104.4	C11—C12—C13	119.5 (3)
C5—C3—H31	108.7	C11—C12—H121	120.9
C3—O4—H41	101.8	C13—C12—H121	119.6
C3—C5—N6	116.5 (2)	C8—C13—C12	121.4 (3)
C3—C5—C15	118.5 (2)	C8—C13—H131	119.5
N6—C5—C15	89.19 (17)	C12—C13—H131	119.1
C3—C5—H51	109.8	N6—C14—C15	89.48 (18)
N6—C5—H51	109.6	N6—C14—H141	111.2
C15—C5—H51	111.8	C15—C14—H141	113.5
C5—N6—C7	115.48 (19)	N6—C14—H142	115.3
C5—N6—C14	89.22 (17)	C15—C14—H142	116.3
C7—N6—C14	114.8 (2)	H141—C14—H142	109.7
N6—C7—C8	111.6 (2)	C5—C15—C14	86.89 (19)
N6—C7—H72	106.5	C5—C15—O16	112.1 (2)
C8—C7—H72	109.0	C14—C15—O16	114.5 (2)
N6—C7—H71	109.8	C5—C15—H151	113.7
C8—C7—H71	109.9	C14—C15—H151	114.9
H72—C7—H71	109.9	O16—C15—H151	112.5
C7—C8—C9	121.6 (2)	C15—O16—H161	104.4

D—H···A	D—H	H···A	D···A	D—H···A
C11—H111···O4i	0.93	2.55	3.457 (4)	164
C15—H151···O4ii	0.96	2.59	3.377 (4)	139
O4—H41···O16iii	0.84	2.18	2.825 (4)	134
O16—H161···O1iv	0.84	1.90	2.735 (4)	171
O1—H11···N6iii	0.86	1.86	2.719 (4)	171

Table 1

Hydrogen-bond geometry (Å, °)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
O4—H41⋯O16i	0.84	2.18	2.825 (4)	134
O16—H161⋯O1ii	0.84	1.90	2.735 (4)	171
O1—H11⋯N6i	0.86	1.86	2.719 (4)	171

Symmetry codes: (i) ; (ii) .