UNLABELLED: Using combined dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography, we demonstrate that men matched with women for femoral neck (FN) areal bone mineral density (aBMD) have lower volumetric BMD (vBMD), higher bone cross-sectional area, and relatively similar values for finite element (FE)-derived bone strength. INTRODUCTION: aBMD by DXA is widely used to identify patients at risk for osteoporotic fractures. aBMD is influenced by bone size (i.e., matched for vBMD, larger bones have higher aBMD), and increasing evidence indicates that absolute aBMD predicts a similar risk of fracture in men and women. Thus, we sought to define the relationships between FN aBMD (assessed by DXA) and vBMD, bone size, and FE-derived femoral strength obtained from quantitative computed tomography scans in men versus women. METHODS: We studied men and women aged 40 to 90 years and not on osteoporosis medications. RESULTS: In 114 men and 114 women matched for FN aBMD, FN total cross-sectional area was 38% higher (P < 0.0001) and vBMD was 16% lower (P < 0.0001) in the men. FE models constructed in a subset of 28 women and 28 men matched for FN aBMD showed relatively similar values for bone strength and the load-to-strength ratio in the two groups. CONCLUSIONS: In this cohort of young and old men and women from Rochester, MN, USA who are matched by FN aBMD, because of the offsetting effects of bone size and vBMD, femoral strength and the load-to-strength ratio tended to be relatively similar across the sexes.
UNLABELLED: Using combined dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography, we demonstrate that men matched with women for femoral neck (FN) areal bone mineral density (aBMD) have lower volumetric BMD (vBMD), higher bone cross-sectional area, and relatively similar values for finite element (FE)-derived bone strength. INTRODUCTION: aBMD by DXA is widely used to identify patients at risk for osteoporotic fractures. aBMD is influenced by bone size (i.e., matched for vBMD, larger bones have higher aBMD), and increasing evidence indicates that absolute aBMD predicts a similar risk of fracture in men and women. Thus, we sought to define the relationships between FN aBMD (assessed by DXA) and vBMD, bone size, and FE-derived femoral strength obtained from quantitative computed tomography scans in men versus women. METHODS: We studied men and women aged 40 to 90 years and not on osteoporosis medications. RESULTS: In 114 men and 114 women matched for FN aBMD, FN total cross-sectional area was 38% higher (P < 0.0001) and vBMD was 16% lower (P < 0.0001) in the men. FE models constructed in a subset of 28 women and 28 men matched for FN aBMD showed relatively similar values for bone strength and the load-to-strength ratio in the two groups. CONCLUSIONS: In this cohort of young and old men and women from Rochester, MN, USA who are matched by FN aBMD, because of the offsetting effects of bone size and vBMD, femoral strength and the load-to-strength ratio tended to be relatively similar across the sexes.
Authors: Steven R Cummings; Peggy M Cawthon; Kristine E Ensrud; Jane A Cauley; Howard A Fink; Eric S Orwoll Journal: J Bone Miner Res Date: 2006-10 Impact factor: 6.741
Authors: B Lawrence Riggs; L Joseph Melton Iii; Richard A Robb; Jon J Camp; Elizabeth J Atkinson; James M Peterson; Peggy A Rouleau; Cynthia H McCollough; Mary L Bouxsein; Sundeep Khosla Journal: J Bone Miner Res Date: 2004-09-20 Impact factor: 6.741
Authors: Olof Johnell; John A Kanis; Anders Oden; Helena Johansson; Chris De Laet; Pierre Delmas; John A Eisman; Seiko Fujiwara; Heikki Kroger; Dan Mellstrom; Pierre J Meunier; L Joseph Melton; Terry O'Neill; Huibert Pols; Jonathan Reeve; Alan Silman; Alan Tenenhouse Journal: J Bone Miner Res Date: 2005-03-07 Impact factor: 6.741
Authors: B Lawrence Riggs; L Joseph Melton; Richard A Robb; Jon J Camp; Elizabeth J Atkinson; Lisa McDaniel; Shreyasee Amin; Peggy A Rouleau; Sundeep Khosla Journal: J Bone Miner Res Date: 2008-02 Impact factor: 6.741
Authors: L Wang; X G Cheng; Y B Su; K Brown; L Xu; K Li; C X Zhang; Y Zhang; Y Y Duanmu; X B Wu; M Y Wang Journal: Osteoporos Int Date: 2017-04-12 Impact factor: 4.507
Authors: Katherine N Bachmann; Melanie Schorr; Alexander G Bruno; Miriam A Bredella; Elizabeth A Lawson; Corey M Gill; Vibha Singhal; Erinne Meenaghan; Anu V Gerweck; Meghan Slattery; Kamryn T Eddy; Seda Ebrahimi; Stuart L Koman; James M Greenblatt; Robert J Keane; Thomas Weigel; Madhusmita Misra; Mary L Bouxsein; Anne Klibanski; Karen K Miller Journal: J Clin Endocrinol Metab Date: 2017-01-01 Impact factor: 5.958
Authors: Alexander G Bruno; Kerry E Broe; Xiaochun Zhang; Elizabeth J Samelson; Ching-An Meng; Rajaram Manoharan; John D'Agostino; L Adrienne Cupples; Douglas P Kiel; Mary L Bouxsein Journal: J Bone Miner Res Date: 2014-03 Impact factor: 6.741
Authors: Annette L Adams; Heidi Fischer; David L Kopperdahl; David C Lee; Dennis M Black; Mary L Bouxsein; Shireen Fatemi; Sundeep Khosla; Eric S Orwoll; Ethel S Siris; Tony M Keaveny Journal: J Bone Miner Res Date: 2018-04-17 Impact factor: 6.741