Pooja Khatri1, Mark R Conaway, Karen C Johnston. 1. Department of Neurology, University of Cincinnati, 260 Stetson Street, Suite 2300, ML 0525, Cincinnati, OH 45267-0525, USA. pooja.khatri@uc.edu
Abstract
BACKGROUND AND PURPOSE: Prior studies have shown that patients with mild ischemic stroke have substantial disability rates at hospital discharge. We sought to determine disability rates at 90 days among patients not treated with thrombolytic therapy and explore the role of early neurological worsening. METHODS: We reviewed a prospective cohort of 136 consecutive patients with mild deficits (National Institutes of Health Stroke Scale score ≤ 5) presenting within 24 hours of onset and no baseline disability. Baseline MRIs were performed on all subjects. Five-day MRIs were performed on a prespecified subcohort. RESULTS: Among 136 patients, 40 (29%; 95% CI, 22%-38%) had poor outcomes (modified Rankin Scale score 2-6) at 90 days. Early worsening (4-point National Institutes of Health Stroke Scale increase; 25% versus 1%, P<0.001) and acute infarct growth (>10% on MRI-diffusion-weighted imaging; 79% versus 53%, P=0.02) from baseline to 5 days were more common among those with poor outcome. CONCLUSIONS: Patients with mild ischemic stroke have substantial rates (29%) of disability at 90 days.
BACKGROUND AND PURPOSE: Prior studies have shown that patients with mild ischemic stroke have substantial disability rates at hospital discharge. We sought to determine disability rates at 90 days among patients not treated with thrombolytic therapy and explore the role of early neurological worsening. METHODS: We reviewed a prospective cohort of 136 consecutive patients with mild deficits (National Institutes of Health Stroke Scale score ≤ 5) presenting within 24 hours of onset and no baseline disability. Baseline MRIs were performed on all subjects. Five-day MRIs were performed on a prespecified subcohort. RESULTS: Among 136 patients, 40 (29%; 95% CI, 22%-38%) had poor outcomes (modified Rankin Scale score 2-6) at 90 days. Early worsening (4-point National Institutes of Health Stroke Scale increase; 25% versus 1%, P<0.001) and acute infarct growth (>10% on MRI-diffusion-weighted imaging; 79% versus 53%, P=0.02) from baseline to 5 days were more common among those with poor outcome. CONCLUSIONS:Patients with mild ischemic stroke have substantial rates (29%) of disability at 90 days.
Authors: Eric E Smith; Abdul R Abdullah; Iva Petkovska; Eric Rosenthal; Walter J Koroshetz; Lee H Schwamm Journal: Stroke Date: 2005-10-06 Impact factor: 7.914
Authors: Pooja Khatri; Dawn O Kleindorfer; Sharon D Yeatts; Jeffrey L Saver; Steven R Levine; Patrick D Lyden; Charles J Moomaw; Yuko Y Palesch; Edward C Jauch; Joseph P Broderick Journal: Stroke Date: 2010-09-02 Impact factor: 7.914
Authors: Urs Fischer; Adrian Baumgartner; Marcel Arnold; Krassen Nedeltchev; Jan Gralla; Gian Marco De Marchis; Liliane Kappeler; Marie-Luise Mono; Caspar Brekenfeld; Gerhard Schroth; Heinrich P Mattle Journal: Stroke Date: 2010-02-25 Impact factor: 7.914
Authors: Dawn Kleindorfer; Brett Kissela; Alex Schneider; Daniel Woo; Jane Khoury; Rosemary Miller; Kathleen Alwell; James Gebel; Jerzy Szaflarski; Arthur Pancioli; Edward Jauch; Charles Moomaw; Rakesh Shukla; Joseph P Broderick Journal: Stroke Date: 2004-01-22 Impact factor: 7.914
Authors: Mandip S Dhamoon; Yeseon Park Moon; Myunghee C Paik; Bernadette Boden-Albala; Tatjana Rundek; Ralph L Sacco; Mitchell S V Elkind Journal: Stroke Date: 2009-06-25 Impact factor: 7.914
Authors: Latisha K Ali; Julius K Weng; Sidney Starkman; Jeffrey L Saver; Doojin Kim; Bruce Ovbiagele; Brian H Buck; Nerses Sanossian; Paul Vespa; Oh Young Bang; Reza Jahan; Gary R Duckwiler; Fernando Viñuela; David S Liebeskind Journal: Interv Neurol Date: 2016-09-30
Authors: Shadi Yaghi; Charlotte Herber; Amelia K Boehme; Howard Andrews; Joshua Z Willey; Sara K Rostanski; Matthew Siket; Mahesh V Jayaraman; Ryan A McTaggart; Karen L Furie; Randolph S Marshall; Ronald M Lazar; Bernadette Boden-Albala Journal: J Neuroimaging Date: 2017-01-09 Impact factor: 2.486
Authors: Robert A Frank; Santanu Chakraborty; Trevor McGrath; Alexander Mungham; James Ross; Dar Dowlatshahi; Michel Shamy; Grant Stotts Journal: Neuroradiol J Date: 2018-05-03
Authors: Heidi Sucharew; Jane Khoury; Charles J Moomaw; Kathleen Alwell; Brett M Kissela; Samir Belagaje; Opeolu Adeoye; Pooja Khatri; Daniel Woo; Matthew L Flaherty; Simona Ferioli; Laura Heitsch; Joseph P Broderick; Dawn Kleindorfer Journal: Stroke Date: 2013-05-23 Impact factor: 7.914
Authors: Shadi Yaghi; Joshua Z Willey; Howard Andrews; Amelia K Boehme; Randolph S Marshall; Bernadette Boden-Albala Journal: Neurohospitalist Date: 2016-04-05