Scanned proton radiotherapy for mobile targets-the effectiveness of re-scanning in the context of different treatment planning approaches and for different motion characteristics.

The most advanced delivery technique for proton radiotherapy is active spot scanning. So far, predominantly static targets have been treated with active spot scanning, since mobile targets in combination with dynamic treatment delivery can lead to interplay effects, causing inhomogeneous dose distributions. One way to mitigate motion effects is re-scanning. In this study we investigate the effectiveness of re-scanning in relation to different plan parameters (number of fields, field directions, number of re-scans) as well as in respect to different motion parameters (motion amplitude, motion starting phase). A systematic study was performed for three liver patients, for which ten different plans have been calculated, respectively. The treatment plans were evaluated for three different scenarios (static, motion/single-scan-delivery, motion/re-scanned-delivery). The choice of motion parameters was based on an evaluation of the 4D CT data sets of the three patients. It is shown that the effect of motion/re-scanning per fraction is largest the fewer fields per plan are used and the more the field direction differs from the main motion direction. For amplitudes up to 6 mm, re-scanning may not be required if multiple fields are used, since only dose blurring effects appear that cannot be compensated by re-scanning. For larger motion amplitudes two planning strategies are proposed.