Literature DB >> 22027962

Advances in metal-carbene complexes as potent anti-cancer agents.

Arnaud Gautier1, Federico Cisnetti.   

Abstract

This critical review is an updated survey of metal-carbenes as potential anticancer chemotherapeutics. We report on the recent advances in the discovery of N-heterocyclic carbenes, acyclic diamino carbenes and abnormal NHCs associated with metals from groups 10 and 11 that displayed antiproliferative activity and emphasize, when possible, their molecular target(s) and their mechanism of action. This journal is © The Royal Society of Chemistry 2012

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Year:  2011        PMID： 22027962     DOI： 10.1039/c1mt00123j

Source DB:  PubMed          Journal:  Metallomics        ISSN： 1756-5901            Impact factor:   4.526


  15 in total

1.  Anti-tumor activity of lipophilic imidazolium salts on select NSCLC cell lines.

Authors:  Brian D Wright; Michael C Deblock; Patrick O Wagers; Ernest Duah; Nikki K Robishaw; Kerri L Shelton; Marie R Southerland; Michael A DeBord; Kortney M Kersten; Lucas J McDonald; Jason A Stiel; Matthew J Panzner; Claire A Tessier; Sailaja Paruchuri; Wiley J Youngs
Journal:  Med Chem Res       Date:  2015-02-13       Impact factor: 1.965

2.  Extending N-heterocyclic carbene ligands into the third dimension: a new type of hybrid phosphazane/NHC system.

Authors:  Torsten Roth; Vladislav Vasilenko; Callum G M Benson; Hubert Wadepohl; Dominic S Wright; Lutz H Gade
Journal:  Chem Sci       Date:  2015-02-13       Impact factor: 9.825

3.  Cytotoxicity of Pyrazine-Based Cyclometalated (C^Npz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties.

Authors:  Benoît Bertrand; Julio Fernandez-Cestau; Jesus Angulo; Marco M D Cominetti; Zoë A E Waller; Mark Searcey; Maria A O'Connell; Manfred Bochmann
Journal:  Inorg Chem       Date:  2017-04-25       Impact factor: 5.165

Review 4.  Recent Developments in the Medicinal Applications of Silver-NHC Complexes and Imidazolium Salts.

Authors:  Nicholas A Johnson; Marie R Southerland; Wiley J Youngs
Journal:  Molecules       Date:  2017-07-27       Impact factor: 4.411

5.  N-Heterocyclic Carbene-Polyethyleneimine (PEI) Platinum Complexes Inducing Human Cancer Cell Death: Polymer Carrier Impact.

Authors:  May Wantz; Mathilde Bouché; Georges Dahm; Neïla Chekkat; Sylvie Fournel; Stéphane Bellemin-Laponnaz
Journal:  Int J Mol Sci       Date:  2018-11-05       Impact factor: 5.923

6.  Potential of silver against human colon cancer: (synthesis, characterization and crystal structures of xylyl (Ortho, meta, &Para) linked bis-benzimidazolium salts and Ag(I)-NHC complexes: In vitro anticancer studies).

Authors:  Muhammad Adnan Iqbal; Rosenani A Haque; Siti Fatimah Nasri; Ams Abdul Majid; Mohamed B Khadeer Ahamed; Elham Farsi; Tabinda Fatima
Journal:  Chem Cent J       Date:  2013-02-07       Impact factor: 4.215

7.  Biological Screening of Newly Synthesized BIAN N-Heterocyclic Gold Carbene Complexes in Zebrafish Embryos.

Authors:  Muhammad Farooq; Nael Abu Taha; Rachel R Butorac; Daniel Anthony Evans; Ahmed A Elzatahry; Elsayed Ahmed Elsayed; Mohammad A M Wadaan; Salem S Al-Deyab; Alan H Cowley
Journal:  Int J Mol Sci       Date:  2015-10-16       Impact factor: 5.923

8.  Cymantrenyl-Nucleobases: Synthesis, Anticancer, Antitrypanosomal and Antimicrobial Activity Studies.

Authors:  Artur Jabłoński; Karolina Matczak; Aneta Koceva-Chyła; Kamil Durka; Dietmar Steverding; Katarzyna Jakubiec-Krześniak; Jolanta Solecka; Damian Trzybiński; Krzysztof Woźniak; Vanesa Andreu; Gracia Mendoza; Manuel Arruebo; Krzysztof Kochel; Barbara Krawczyk; Dominik Szczukocki; Konrad Kowalski
Journal:  Molecules       Date:  2017-12-14       Impact factor: 4.411

Review 9.  Gold-Based Medicine: A Paradigm Shift in Anti-Cancer Therapy?

Authors:  Chien Ing Yeo; Kah Kooi Ooi; Edward R T Tiekink
Journal:  Molecules       Date:  2018-06-11       Impact factor: 4.411

10.  Synthesis and Biological Evaluation of Homogeneous Thiol-Linked NHC*-Au-Albumin and -Trastuzumab Bioconjugates.

Authors:  Maria J Matos; Carlos Labão-Almeida; Claire Sayers; Oyinlola Dada; Matthias Tacke; Gonçalo J L Bernardes
Journal:  Chemistry       Date:  2018-05-22       Impact factor: 5.236
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