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Literature DB >> 22024272

Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors.

Bini Mathew¹, Shefali Srivastava, Larry J Ross, William J Suling, E Lucile White, Lisa K Woolhiser, Anne J Lenaerts, Robert C Reynolds.

Abstract

A series of pyridopyrazine and pyrimidothiazine derivatives have been synthesized and their activity against FtsZ from Mycobacterium tuberculosis (Mtb) and in vitro antibacterial activity against Mtb H(37)Ra and Mtb H(37)Rv are reported. Certain analogs described herein showed moderate to good inhibitory activity.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 2011 PMID： 22024272 PMCID： PMC3216299 DOI： 10.1016/j.bmc.2011.09.062

Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641

18 in total

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3. Synthesis of potential antimalarial agents. II. 6,8-Disubstituted pyrido(2,3-b)pyrazines.

Authors: C Temple; J D Rose; R D Elliott; J A Montgomery
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4. Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents.

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Review 5. FtsZ, a prokaryotic homolog of tubulin?

Authors: H P Erickson
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Authors: C Temple; G P Wheeler; R N Comber; R D Elliott; J A Montgomery
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9. 2-Alkoxycarbonylaminopyridines: inhibitors of Mycobacterium tuberculosis FtsZ.

Authors: E Lucile White; William J Suling; Larry J Ross; Lainne E Seitz; Robert C Reynolds
Journal: J Antimicrob Chemother Date: 2002-07 Impact factor: 5.790

10. Pyrimidines. 18. 2,4-diamino-5-nitro-6-arylaminopyrimidines. Nitration study of 2,4-diamino-6-chloropyrimidine and a literature correction.

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Review 3. Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ.

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4. SAR studies on trisubstituted benzimidazoles as inhibitors of Mtb FtsZ for the development of novel antitubercular agents.

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5. Cell division inhibitors with efficacy equivalent to isoniazid in the acute murine Mycobacterium tuberculosis infection model.

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Journal: J Antimicrob Chemother Date: 2015-08-05 Impact factor: 5.790

6. A novel quinoline derivative that inhibits mycobacterial FtsZ.

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Journal: Tuberculosis (Edinb) Date: 2013-05-04 Impact factor: 3.131

7. Comparison of small molecule inhibitors of the bacterial cell division protein FtsZ and identification of a reliable cross-species inhibitor.

Authors: David E Anderson; Michelle B Kim; Jared T Moore; Terrence E O'Brien; Nohemy A Sorto; Charles I Grove; Laura L Lackner; James B Ames; Jared T Shaw
Journal: ACS Chem Biol Date: 2012-10-05 Impact factor: 5.100