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Literature DB >> 2201908

SPT6, an essential gene that affects transcription in Saccharomyces cerevisiae, encodes a nuclear protein with an extremely acidic amino terminus.

Abstract

SPT6 is an essential gene of Saccharomyces cerevisiae that appears to play a role in transcription. Mutations in the SPT6 (SSN20, CRE2) gene suppress delta insertion mutations in the 5' regions of HIS4 and LYS2 and mutations in cis- and/or trans-acting elements that are required for expression of SUC2 and ADH2. We report here that SPT6 encodes a 170-kilodalton highly charged protein with an extremely acidic amino terminus. By use of an epitope-tagged SPT6 protein, we have determined by indirect immunofluorescence that the SPT6 protein is located in the nucleus.

Entities: Gene Species

Mesh：

Substances：

Year: 1990 PMID： 2201908 PMCID： PMC361114 DOI： 10.1128/mcb.10.9.4935-4941.1990

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

32 in total

1. Deletion analysis of GAL4 defines two transcriptional activating segments.

Authors: J Ma; M Ptashne
Journal: Cell Date: 1987-03-13 Impact factor: 41.582

2. Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition.

Authors: H L Niman; R A Houghten; L E Walker; R A Reisfeld; I A Wilson; J M Hogle; R A Lerner
Journal: Proc Natl Acad Sci U S A Date: 1983-08 Impact factor: 11.205

3. Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis.

Authors: J Norrander; T Kempe; J Messing
Journal: Gene Date: 1983-12 Impact factor: 3.688

4. Yeast shuttle and integrative vectors with multiple cloning sites suitable for construction of lacZ fusions.

Authors: A M Myers; A Tzagoloff; D M Kinney; C J Lusty
Journal: Gene Date: 1986 Impact factor: 3.688

5. Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast.

Authors: I A Hope; K Struhl
Journal: Cell Date: 1986-09-12 Impact factor: 41.582

6. Mutations affecting Ty-mediated expression of the HIS4 gene of Saccharomyces cerevisiae.

Authors: F Winston; D T Chaleff; B Valent; G R Fink
Journal: Genetics Date: 1984-06 Impact factor: 4.562

7. A yeast gene that is essential for release from glucose repression encodes a protein kinase.

Authors: J L Celenza; M Carlson
Journal: Science Date: 1986-09-12 Impact factor: 47.728

8. Suppressors of SNF2 mutations restore invertase derepression and cause temperature-sensitive lethality in yeast.

Authors: L Neigeborn; K Rubin; M Carlson
Journal: Genetics Date: 1986-04 Impact factor: 4.562

9. Genes affecting the regulation of SUC2 gene expression by glucose repression in Saccharomyces cerevisiae.

Authors: L Neigeborn; M Carlson
Journal: Genetics Date: 1984-12 Impact factor: 4.562

10. Structural rearrangements of tubulin and actin during the cell cycle of the yeast Saccharomyces.

Authors: J V Kilmartin; A E Adams
Journal: J Cell Biol Date: 1984-03 Impact factor: 10.539

42 in total

1. BUR1 and BUR2 encode a divergent cyclin-dependent kinase-cyclin complex important for transcription in vivo.

Authors: S Yao; A Neiman; G Prelich
Journal: Mol Cell Biol Date: 2000-10 Impact factor: 4.272

2. Oligonucleotide-directed site-specific integration of high complexity libraries into ssDNA templates.

Authors: M B Hale; G P Nolan; R Wolkowicz
Journal: Nucleic Acids Res Date: 2004-01-29 Impact factor: 16.971

3. An essential Saccharomyces cerevisiae gene homologous to SNF2 encodes a helicase-related protein in a new family.

Authors: B C Laurent; X Yang; M Carlson
Journal: Mol Cell Biol Date: 1992-04 Impact factor: 4.272

4. The SNF5 protein of Saccharomyces cerevisiae is a glutamine- and proline-rich transcriptional activator that affects expression of a broad spectrum of genes.

Authors: B C Laurent; M A Treitel; M Carlson
Journal: Mol Cell Biol Date: 1990-11 Impact factor: 4.272

5. New nucleotide sequence data on the EMBL File Server.

Authors:
Journal: Nucleic Acids Res Date: 1991-06-11 Impact factor: 16.971

6. A tandem SH2 domain in transcription elongation factor Spt6 binds the phosphorylated RNA polymerase II C-terminal repeat domain (CTD).

Authors: Mai Sun; Laurent Larivière; Stefan Dengl; Andreas Mayer; Patrick Cramer
Journal: J Biol Chem Date: 2010-10-06 Impact factor: 5.157

7. Molecular and genetic characterization of SPT4, a gene important for transcription initiation in Saccharomyces cerevisiae.

Authors: E A Malone; J S Fassler; F Winston
Journal: Mol Gen Genet Date: 1993-03

8. SPT5, an essential gene important for normal transcription in Saccharomyces cerevisiae, encodes an acidic nuclear protein with a carboxy-terminal repeat.

Authors: M S Swanson; E A Malone; F Winston
Journal: Mol Cell Biol Date: 1991-06 Impact factor: 4.272

9. Identification and analysis of a functional human homolog of the SPT4 gene of Saccharomyces cerevisiae.

Authors: G A Hartzog; M A Basrai; S L Ricupero-Hovasse; P Hieter; F Winston
Journal: Mol Cell Biol Date: 1996-06 Impact factor: 4.272

10. Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor.

Authors: H Chiba; M Muramatsu; A Nomoto; H Kato
Journal: Nucleic Acids Res Date: 1994-05-25 Impact factor: 16.971