Literature DB >> 1549132

An essential Saccharomyces cerevisiae gene homologous to SNF2 encodes a helicase-related protein in a new family.

B C Laurent1, X Yang, M Carlson.   

Abstract

The Saccharomyces cerevisiae SNF2 gene affects the expression of many diversely regulated genes and has been implicated in transcriptional activation. We report here the cloning and characterization of STH1, a gene that is homologous to SNF2. STH1 is essential for mitotic growth and is functionally distinct from SNF2. A bifunctional STH1-beta-galactosidase protein is located in the nucleus. The predicted 155,914-Da STH1 protein is 72% identical to SNF2 over 661 amino acids and 46% identical over another stretch of 66 amino acids. Both STH1 and SNF2 contain a putative nucleoside triphosphate-binding site and sequences resembling the consensus helicase motifs. The large region of homology shared by STH1 and SNF2 is conserved among other eukaryotic proteins, and STH1 and SNF2 appear to define a novel family of proteins related to helicases.

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Year:  1992        PMID： 1549132      PMCID： PMC369633          DOI： 10.1128/mcb.12.4.1893-1902.1992

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  66 in total

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Journal:  Nucleic Acids Res       Date:  1989-09-25       Impact factor: 16.971

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Authors:  B C Laurent; M A Treitel; M Carlson
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Journal:  Dev Biol       Date:  1989-07       Impact factor: 3.582

Review 4.  A regulatory hierarchy for cell specialization in yeast.

Authors:  I Herskowitz
Journal:  Nature       Date:  1989-12-14       Impact factor: 49.962

5.  Structure and associated DNA-helicase activity of a general transcription initiation factor that binds to RNA polymerase II.

Authors:  M Sopta; Z F Burton; J Greenblatt
Journal:  Nature       Date:  1989-10-05       Impact factor: 49.962

6.  Three-dimensional structure of an oncogene protein: catalytic domain of human c-H-ras p21.

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Journal:  Science       Date:  1988-02-19       Impact factor: 47.728

7.  A conserved NTP-motif in putative helicases.

Authors:  A E Gorbalenya; E V Koonin; A P Donchenko; V M Blinov
Journal:  Nature       Date:  1988-05-05       Impact factor: 49.962

8.  The N-terminal TPR region is the functional domain of SSN6, a nuclear phosphoprotein of Saccharomyces cerevisiae.

Authors:  J Schultz; L Marshall-Carlson; M Carlson
Journal:  Mol Cell Biol       Date:  1990-09       Impact factor: 4.272

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Authors:  M S Swanson; E A Malone; F Winston
Journal:  Mol Cell Biol       Date:  1991-06       Impact factor: 4.272

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Authors:  H Yoshimoto; I Yamashita
Journal:  Mol Gen Genet       Date:  1991-08
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  69 in total

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4.  A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes.

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Authors:  B E Strober; J L Dunaief; S P Goff
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7.  A mutation in NPS1/STH1, an essential gene encoding a component of a novel chromatin-remodeling complex RSC, alters the chromatin structure of Saccharomyces cerevisiae centromeres.

Authors:  E Tsuchiya; T Hosotani; T Miyakawa
Journal:  Nucleic Acids Res       Date:  1998-07-01       Impact factor: 16.971

8.  Sth1p, a Saccharomyces cerevisiae Snf2p/Swi2p homolog, is an essential ATPase in RSC and differs from Snf/Swi in its interactions with histones and chromatin-associated proteins.

Authors:  J Du; I Nasir; B K Benton; M P Kladde; B C Laurent
Journal:  Genetics       Date:  1998-11       Impact factor: 4.562

9.  Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor.

Authors:  H Chiba; M Muramatsu; A Nomoto; H Kato
Journal:  Nucleic Acids Res       Date:  1994-05-25       Impact factor: 16.971

10.  The male-specific lethal-one (msl-1) gene of Drosophila melanogaster encodes a novel protein that associates with the X chromosome in males.

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