Literature DB >> 22014568

The spliceosome as an indicted conspirator in myeloid malignancies.

Omar Abdel-Wahab1, Ross Levine.   

Abstract

Reports of whole-exome sequencing in myelodysplastic syndrome (MDS) patients by Yoshida et al. and Papaemmanuil et al. suggest spliceosome mutations have clinical relevance. Identifying the impact of these mutations on MDS pathogenesis holds promise for therapeutic modulation of mRNA splicing.
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID： 22014568      PMCID： PMC3218079          DOI： 10.1016/j.ccr.2011.10.004

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  10 in total

1.  Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1.

Authors:  Kyoichi Isono; Yoko Mizutani-Koseki; Toshihisa Komori; Marion S Schmidt-Zachmann; Haruhiko Koseki
Journal:  Genes Dev       Date:  2005-03-01       Impact factor: 11.361

2.  Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

Authors:  Daisuke Kaida; Hajime Motoyoshi; Etsu Tashiro; Takayuki Nojima; Masatoshi Hagiwara; Ken Ishigami; Hidenori Watanabe; Takeshi Kitahara; Tatsuhiko Yoshida; Hidenori Nakajima; Tokio Tani; Sueharu Horinouchi; Minoru Yoshida
Journal:  Nat Chem Biol       Date:  2007-07-22       Impact factor: 15.040

3.  ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle.

Authors:  Xiangdong Xu; Dongmei Yang; Jian-Hua Ding; Wang Wang; Pao-Hsien Chu; Nancy D Dalton; Huan-You Wang; John R Bermingham; Zhen Ye; Forrest Liu; Michael G Rosenfeld; James L Manley; John Ross; Ju Chen; Rui-Ping Xiao; Heping Cheng; Xiang-Dong Fu
Journal:  Cell       Date:  2005-01-14       Impact factor: 41.582

4.  Frequent pathway mutations of splicing machinery in myelodysplasia.

Authors:  Kenichi Yoshida; Masashi Sanada; Yuichi Shiraishi; Daniel Nowak; Yasunobu Nagata; Ryo Yamamoto; Yusuke Sato; Aiko Sato-Otsubo; Ayana Kon; Masao Nagasaki; George Chalkidis; Yutaka Suzuki; Masashi Shiosaka; Ryoichiro Kawahata; Tomoyuki Yamaguchi; Makoto Otsu; Naoshi Obara; Mamiko Sakata-Yanagimoto; Ken Ishiyama; Hiraku Mori; Florian Nolte; Wolf-Karsten Hofmann; Shuichi Miyawaki; Sumio Sugano; Claudia Haferlach; H Phillip Koeffler; Lee-Yung Shih; Torsten Haferlach; Shigeru Chiba; Hiromitsu Nakauchi; Satoru Miyano; Seishi Ogawa
Journal:  Nature       Date:  2011-09-11       Impact factor: 49.962

5.  Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation.

Authors:  Annelie E Abrahamsson; Ifat Geron; Jason Gotlib; Kim-Hien T Dao; Charlene F Barroga; Isabel G Newton; Francis J Giles; Jeffrey Durocher; Remi S Creusot; Mobin Karimi; Carol Jones; James L Zehnder; Armand Keating; Robert S Negrin; Irving L Weissman; Catriona H M Jamieson
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-23       Impact factor: 11.205

6.  A comprehensive catalogue of somatic mutations from a human cancer genome.

Authors:  Erin D Pleasance; R Keira Cheetham; Philip J Stephens; David J McBride; Sean J Humphray; Chris D Greenman; Ignacio Varela; Meng-Lay Lin; Gonzalo R Ordóñez; Graham R Bignell; Kai Ye; Julie Alipaz; Markus J Bauer; David Beare; Adam Butler; Richard J Carter; Lina Chen; Anthony J Cox; Sarah Edkins; Paula I Kokko-Gonzales; Niall A Gormley; Russell J Grocock; Christian D Haudenschild; Matthew M Hims; Terena James; Mingming Jia; Zoya Kingsbury; Catherine Leroy; John Marshall; Andrew Menzies; Laura J Mudie; Zemin Ning; Tom Royce; Ole B Schulz-Trieglaff; Anastassia Spiridou; Lucy A Stebbings; Lukasz Szajkowski; Jon Teague; David Williamson; Lynda Chin; Mark T Ross; Peter J Campbell; David R Bentley; P Andrew Futreal; Michael R Stratton
Journal:  Nature       Date:  2009-12-16       Impact factor: 49.962

7.  Local dystrophin restoration with antisense oligonucleotide PRO051.

Authors:  Judith C van Deutekom; Anneke A Janson; Ieke B Ginjaar; Wendy S Frankhuizen; Annemieke Aartsma-Rus; Mattie Bremmer-Bout; Johan T den Dunnen; Klaas Koop; Anneke J van der Kooi; Nathalie M Goemans; Sjef J de Kimpe; Peter F Ekhart; Edna H Venneker; Gerard J Platenburg; Jan J Verschuuren; Gert-Jan B van Ommen
Journal:  N Engl J Med       Date:  2007-12-27       Impact factor: 91.245

8.  Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart.

Authors:  Jian-Hua Ding; Xiangdong Xu; Dongmei Yang; Pao-Hsien Chu; Nancy D Dalton; Zhen Ye; Joanne M Yeakley; Heping Cheng; Rui-Ping Xiao; John Ross; Ju Chen; Xiang-Dong Fu
Journal:  EMBO J       Date:  2004-02-12       Impact factor: 11.598

9.  The genomic landscapes of human breast and colorectal cancers.

Authors:  Laura D Wood; D Williams Parsons; Siân Jones; Jimmy Lin; Tobias Sjöblom; Rebecca J Leary; Dong Shen; Simina M Boca; Thomas Barber; Janine Ptak; Natalie Silliman; Steve Szabo; Zoltan Dezso; Vadim Ustyanksky; Tatiana Nikolskaya; Yuri Nikolsky; Rachel Karchin; Paul A Wilson; Joshua S Kaminker; Zemin Zhang; Randal Croshaw; Joseph Willis; Dawn Dawson; Michail Shipitsin; James K V Willson; Saraswati Sukumar; Kornelia Polyak; Ben Ho Park; Charit L Pethiyagoda; P V Krishna Pant; Dennis G Ballinger; Andrew B Sparks; James Hartigan; Douglas R Smith; Erick Suh; Nickolas Papadopoulos; Phillip Buckhaults; Sanford D Markowitz; Giovanni Parmigiani; Kenneth W Kinzler; Victor E Velculescu; Bert Vogelstein
Journal:  Science       Date:  2007-10-11       Impact factor: 47.728

10.  Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts.

Authors:  E Papaemmanuil; M Cazzola; J Boultwood; L Malcovati; P Vyas; D Bowen; A Pellagatti; J S Wainscoat; E Hellstrom-Lindberg; C Gambacorti-Passerini; A L Godfrey; I Rapado; A Cvejic; R Rance; C McGee; P Ellis; L J Mudie; P J Stephens; S McLaren; C E Massie; P S Tarpey; I Varela; S Nik-Zainal; H R Davies; A Shlien; D Jones; K Raine; J Hinton; A P Butler; J W Teague; E J Baxter; J Score; A Galli; M G Della Porta; E Travaglino; M Groves; S Tauro; N C Munshi; K C Anderson; A El-Naggar; A Fischer; V Mustonen; A J Warren; N C P Cross; A R Green; P A Futreal; M R Stratton; P J Campbell
Journal:  N Engl J Med       Date:  2011-09-26       Impact factor: 91.245
  10 in total
  19 in total

Review 1.  Standardizing the initial evaluation for myelodysplastic syndromes.

Authors:  Danielle Marshall; Gail J Roboz
Journal:  Curr Hematol Malig Rep       Date:  2013-12       Impact factor: 3.952

Review 2.  New connections between splicing and human disease.

Authors:  Richard A Padgett
Journal:  Trends Genet       Date:  2012-03-05       Impact factor: 11.639

3.  In vivo mutation of pre-mRNA processing factor 8 (Prpf8) affects transcript splicing, cell survival and myeloid differentiation.

Authors:  Maria-Cristina Keightley; Meredith O Crowhurst; Judith E Layton; Traude Beilharz; Sebastian Markmiller; Sony Varma; Benjamin M Hogan; Tanya A de Jong-Curtain; Joan K Heath; Graham J Lieschke
Journal:  FEBS Lett       Date:  2013-05-25       Impact factor: 4.124

4.  Resistance to imatinib in patients with chronic myelogenous leukemia and the splice variant BCR-ABL1(35INS).

Authors:  Ellin Berman; Suresh Jhanwar; Cyrus Hedvat; Maria E Arcila; Omar Abdel- Wahab; Ross Levine; Molly Maloy; Wanlong Ma; Maher Albitar
Journal:  Leuk Res       Date:  2016-08-12       Impact factor: 3.156

Review 5.  The spliceosome as a target of novel antitumour drugs.

Authors:  Sophie Bonnal; Luisa Vigevani; Juan Valcárcel
Journal:  Nat Rev Drug Discov       Date:  2012-11       Impact factor: 84.694

Review 6.  Stopping higher-risk myelodysplastic syndrome in its tracks.

Authors:  Daniel A Pollyea; Jonathan A Gutman
Journal:  Curr Hematol Malig Rep       Date:  2014-12       Impact factor: 3.952

Review 7.  The changing mutational landscape of acute myeloid leukemia and myelodysplastic syndrome.

Authors:  Connie A Larsson; Gilbert Cote; Alfonso Quintás-Cardama
Journal:  Mol Cancer Res       Date:  2013-05-03       Impact factor: 5.852

Review 8.  There's risk, and then there's risk: The latest clinical prognostic risk stratification models in myelodysplastic syndromes.

Authors:  Amer M Zeidan; Rami S Komrokji
Journal:  Curr Hematol Malig Rep       Date:  2013-12       Impact factor: 3.952

9.  Identification of novel deregulated RNA metabolism-related genes in non-small cell lung cancer.

Authors:  Iñaki Valles; Maria J Pajares; Victor Segura; Elisabet Guruceaga; Javier Gomez-Roman; David Blanco; Akiko Tamura; Luis M Montuenga; Ruben Pio
Journal:  PLoS One       Date:  2012-08-02       Impact factor: 3.240

10.  Prp40 pre-mRNA processing factor 40 homolog B (PRPF40B) associates with SF1 and U2AF65 and modulates alternative pre-mRNA splicing in vivo.

Authors:  Soraya Becerra; Marta Montes; Cristina Hernández-Munain; Carlos Suñé
Journal:  RNA       Date:  2015-01-20       Impact factor: 4.942
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