PURPOSE: To analyze dynamics of retinal vessel dilation response to flicker light in patients with glaucoma and ocular hypertension. PATIENTS AND METHODS: Response to flicker light was measured in retinal vessels by means of Retinal Vessel Analyzer. After the baseline 50 seconds long diameter recording of inferior and superior temporal artery and vein, three flicker stimulations of 20 seconds duration was applied, with a 80 seconds break in between. Area under the curve of the vessel diameter (AUC) was compared during 3 flicker periods in the open angle glaucoma patients group (POAG, n = 47) and ocular hypertensives (OHT, n = 46) and age-matched healthy controls (n = 56) RESULTS: POAG eyes demonstrated smaller response of all vessels to flicker light in general than the other two groups (p = 0.0008), but the response dynamics was significantly different between the groups (p = 0.038), showing in three flicker periods a delayed increasing response in the POAG and OHT groups, and remaining stable in healthy subjects. CONCLUSION: General vessel response to flicker light was decreased in POAG patients despite the slow improvement in repeated flicker stimulation, indicating an altered response pattern.
PURPOSE: To analyze dynamics of retinal vessel dilation response to flicker light in patients with glaucoma and ocular hypertension. PATIENTS AND METHODS: Response to flicker light was measured in retinal vessels by means of Retinal Vessel Analyzer. After the baseline 50 seconds long diameter recording of inferior and superior temporal artery and vein, three flicker stimulations of 20 seconds duration was applied, with a 80 seconds break in between. Area under the curve of the vessel diameter (AUC) was compared during 3 flicker periods in the open angle glaucomapatients group (POAG, n = 47) and ocular hypertensives (OHT, n = 46) and age-matched healthy controls (n = 56) RESULTS: POAG eyes demonstrated smaller response of all vessels to flicker light in general than the other two groups (p = 0.0008), but the response dynamics was significantly different between the groups (p = 0.038), showing in three flicker periods a delayed increasing response in the POAG and OHT groups, and remaining stable in healthy subjects. CONCLUSION: General vessel response to flicker light was decreased in POAG patients despite the slow improvement in repeated flicker stimulation, indicating an altered response pattern.
Authors: Gerhard Garhofer; Toke Bek; Andreas G Boehm; Doina Gherghel; Juan Grunwald; Peter Jeppesen; Hélène Kergoat; Konstantin Kotliar; Ines Lanzl; John V Lovasik; Edgar Nagel; Walthard Vilser; Selim Orgul; Leopold Schmetterer Journal: Acta Ophthalmol Date: 2010-11 Impact factor: 3.761
Authors: Asan Kochkorov; Konstantin Gugleta; Robert Katamay; Josef Flammer; Selim Orgul Journal: Graefes Arch Clin Exp Ophthalmol Date: 2010-02-04 Impact factor: 3.117
Authors: K Gugleta; N Waldmann; A Polunina; A Kochkorov; R Katamay; J Flammer; S Orgul Journal: Graefes Arch Clin Exp Ophthalmol Date: 2013-02-19 Impact factor: 3.117
Authors: Eric Wei; Yali Jia; Ou Tan; Benjamin Potsaid; Jonathan J Liu; Woojhon Choi; James G Fujimoto; David Huang Journal: PLoS One Date: 2013-12-02 Impact factor: 3.240
Authors: Gala Beykin; Anthony M Norcia; Vivek J Srinivasan; Alfredo Dubra; Jeffrey L Goldberg Journal: Prog Retin Eye Res Date: 2020-07-10 Impact factor: 21.198
Authors: Josef Flammer; Katarzyna Konieczka; Rosa M Bruno; Agostino Virdis; Andreas J Flammer; Stefano Taddei Journal: Eur Heart J Date: 2013-02-10 Impact factor: 29.983