Peter J Dyck1, Rickey E Carter, William J Litchy. 1. Peripheral Neuropathy Research Laboratory, Department of Neurology Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA. dyck.peter@mayo.edu
Abstract
INTRODUCTION: In this study we aimed to determine which criteria are valid for nerve conduction (NC) diagnosis of typical diabetic sensorimotor polyneuropathy (DSPN). METHODS: Eight criteria were assessed from among diabetes databases, the Rochester Diabetic Neuropathy Study (RDNS, N = 456), and in healthy subjects (RDNS-HS, N = 330). RESULTS: In the RDNS, the most frequent abnormal attributes (≤2.5th/≥97.5th percentile) are: fibular motor nerve conduction velocity (MNCV; 26.3%); sural sensory nerve conduction velocity (SNAP; 25.4%); tibial MNCV (24.8%); ulnar MNCV (21.3%); fibular F latency (16.9%); and ulnar F latency (16.0%). Normal deviate (from percentiles) composite scores of NC included: representative of neurophysiological abnormalities; sensitive and specific for diagnosis and useful for epidemiological surveys; randomized trials; and medical practice. By contrast, abnormality of one or more attributes in any nerve or abnormally of two most sensitive attributes performed poorly. CONCLUSIONS: Composite sum scores of normal deviates (from percentiles corrected for applicable variables) of sensitive NC attributes and with modifications, RDNS and AAN criteria performed acceptably for diagnosis of DSPN.
INTRODUCTION: In this study we aimed to determine which criteria are valid for nerve conduction (NC) diagnosis of typical diabetic sensorimotor polyneuropathy (DSPN). METHODS: Eight criteria were assessed from among diabetes databases, the Rochester Diabetic Neuropathy Study (RDNS, N = 456), and in healthy subjects (RDNS-HS, N = 330). RESULTS: In the RDNS, the most frequent abnormal attributes (≤2.5th/≥97.5th percentile) are: fibular motor nerve conduction velocity (MNCV; 26.3%); sural sensory nerve conduction velocity (SNAP; 25.4%); tibial MNCV (24.8%); ulnar MNCV (21.3%); fibular F latency (16.9%); and ulnar F latency (16.0%). Normal deviate (from percentiles) composite scores of NC included: representative of neurophysiological abnormalities; sensitive and specific for diagnosis and useful for epidemiological surveys; randomized trials; and medical practice. By contrast, abnormality of one or more attributes in any nerve or abnormally of two most sensitive attributes performed poorly. CONCLUSIONS: Composite sum scores of normal deviates (from percentiles corrected for applicable variables) of sensitive NC attributes and with modifications, RDNS and AAN criteria performed acceptably for diagnosis of DSPN.
Authors: P J Dyck; W Bushek; E M Spring; J L Karnes; W J Litchy; P C O'Brien; F J Service Journal: Diabetes Care Date: 1987 Jul-Aug Impact factor: 19.112
Authors: Solomon Tesfaye; Andrew J M Boulton; Peter J Dyck; Roy Freeman; Michael Horowitz; Peter Kempler; Giuseppe Lauria; Rayaz A Malik; Vincenza Spallone; Aaron Vinik; Luciano Bernardi; Paul Valensi Journal: Diabetes Care Date: 2010-10 Impact factor: 19.112
Authors: Peter J Dyck; Carol J Overland; Phillip A Low; William J Litchy; Jenny L Davies; P James B Dyck; Rickey E Carter; L Joseph Melton; Henning Andersen; James W Albers; Charles F Bolton; John D England; Christopher J Klein; Gareth Llewelyn; Michelle L Mauermann; James W Russell; Dinesh Selvarajah; Wolfgang Singer; A Gordon Smith; Solomon Tesfaye; Adrian Vella Journal: Arch Neurol Date: 2012-12
Authors: JaNean K Engelstad; Sean W Taylor; Lawrence V Witt; Belinda J Hoebing; David N Herrmann; P James B Dyck; Christopher J Klein; David M Johnson; Jenny L Davies; Rickey E Carter; Peter J Dyck Journal: Neurology Date: 2012-10-24 Impact factor: 9.910
Authors: Peter J Dyck; James W Albers; James Wolfe; Charles F Bolton; Nancy Walsh; Christopher J Klein; Andrew J Zafft; James W Russell; Karen Thomas; Jenny L Davies; Rickey E Carter; L Joseph Melton; William J Litchy Journal: Muscle Nerve Date: 2013-07-17 Impact factor: 3.217