Seham E Abdelsadek1,2, Entesar O El Saghier3,4, Sabah I Abdel Raheem5,4. 1. 1Neurology department, Faculty of Medicine for girls, AL-Azhar University, Cairo, Egypt. 2. Riyadh, Saudi Arabia. 3. 2Endocrinology and Metabolism Department, Faculty of Medicine, AL-Azhar University, Cairo, Egypt. 4. 5Faculty of Medicine for Girls, AL-Azhar University, Cairo, Egypt. 5. 3Clinical Pathology Department, Faculty of Medicine, AL-Azhar University, Cairo, Egypt.
Abstract
BACKGROUND: Some clinical studies demonstrated a significant association between vitamin D deficiency and diabetic peripheral neuropathy (DPN). OBJECTIVE: This study aims to evaluate the correlation between serum levels of 25(OH) vitamin D and DPN in Egyptian patients with type 2 diabetes mellitus (T2DM). PATIENTS AND METHOD: Sixty patients were known to have T2DM, which classified into the following: group I included 40 patients with DPN and group II included 20 diabetic patients, without DPN, compared with 30 apparently healthy subjects of matched age and sex as control group. Laboratory investigations including fasting and 2-h postprandial blood glucose levels, serum calcium, phosphorus, glycosylated hemoglobin (HbA1c), lipid profile, serum 25(OH) vitamin D, and nerve conduction studies were carried out for every participant to detect the existence and severity of DPN. RESULTS: Vitamin D deficiency was found in 73.3% of T2DM groups and in 35% of control subjects with statistical significant differences (p < 0.005), and serum level of 25(OH) vitamin D in patients with DPN (21.09 ± 8.38) was less statistically significant than that in patients without DPN (31.12 ± 14.85) (p = 0.001). Mean serum level of 25(OH) vitamin D in patients with painless DPN (10.047 ± 8.12) was less significant than that in patients with painful DPN (18.14 ± 3.85), (p < 0.05). Regression analysis revealed that vitamin D deficiency is one of the independent risk factors of DPN, (OD, 0.914), (p = 0.007). CONCLUSION: Vitamin D deficiency has a significant role in the development and severity of DPN in Egyptian patients with T2DM.
BACKGROUND: Some clinical studies demonstrated a significant association between vitamin D deficiency and diabetic peripheral neuropathy (DPN). OBJECTIVE: This study aims to evaluate the correlation between serum levels of 25(OH) vitamin D and DPN in Egyptian patients with type 2 diabetes mellitus (T2DM). PATIENTS AND METHOD: Sixty patients were known to have T2DM, which classified into the following: group I included 40 patients with DPN and group II included 20 diabetic patients, without DPN, compared with 30 apparently healthy subjects of matched age and sex as control group. Laboratory investigations including fasting and 2-h postprandial blood glucose levels, serum calcium, phosphorus, glycosylated hemoglobin (HbA1c), lipid profile, serum 25(OH) vitamin D, and nerve conduction studies were carried out for every participant to detect the existence and severity of DPN. RESULTS: Vitamin D deficiency was found in 73.3% of T2DM groups and in 35% of control subjects with statistical significant differences (p < 0.005), and serum level of 25(OH) vitamin D in patients with DPN (21.09 ± 8.38) was less statistically significant than that in patients without DPN (31.12 ± 14.85) (p = 0.001). Mean serum level of 25(OH) vitamin D in patients with painless DPN (10.047 ± 8.12) was less significant than that in patients with painful DPN (18.14 ± 3.85), (p < 0.05). Regression analysis revealed that vitamin D deficiency is one of the independent risk factors of DPN, (OD, 0.914), (p = 0.007). CONCLUSION: Vitamin D deficiency has a significant role in the development and severity of DPN in Egyptian patients with T2DM.
Authors: Markus Herrmann; David R Sullivan; Anne-Sophie Veillard; Thomas McCorquodale; Isabella R Straub; Russell Scott; Markku Laakso; Duncan Topliss; Alicia J Jenkins; Stefan Blankenberg; Anthony Burton; Anthony C Keech Journal: Diabetes Care Date: 2014-12-18 Impact factor: 19.112
Authors: T Mezza; G Muscogiuri; G P Sorice; A Prioletta; E Salomone; A Pontecorvi; A Giaccari Journal: Ann Nutr Metab Date: 2012-12-03 Impact factor: 3.374
Authors: Giacomo Zoppini; Anna Galletti; Giovanni Targher; Corinna Brangani; Isabella Pichiri; Maddalena Trombetta; Carlo Negri; Francesca De Santi; Vincenzo Stoico; Vittorio Cacciatori; Enzo Bonora Journal: BMJ Open Diabetes Res Care Date: 2015-04-24
Authors: Dan Ziegler; Barbara Thorand; Haifa Maalmi; Christian Herder; Cornelia Huth; Wolfgang Rathmann; Gidon J Bönhof; Margit Heier; Wolfgang Koenig; Michael Roden; Annette Peters Journal: Int J Obes (Lond) Date: 2022-04-26 Impact factor: 5.551