BACKGROUND: SYNERGY is a large pooled analysis of case-control studies on the joint effects of occupational carcinogens and smoking in the development of lung cancer. A quantitative job-exposure matrix (JEM) will be developed to assign exposures to five major lung carcinogens [asbestos, chromium, nickel, polycyclic aromatic hydrocarbons (PAH), and respirable crystalline silica (RCS)]. We assembled an exposure database, called ExpoSYN, to enable such a quantitative exposure assessment. METHODS: Existing exposure databases were identified and European and Canadian research institutes were approached to identify pertinent exposure measurement data. Results of individual air measurements were entered anonymized according to a standardized protocol. RESULTS: The ExpoSYN database currently includes 356 551 measurements from 19 countries. In total, 140 666 personal and 215 885 stationary data points were available. Measurements were distributed over the five agents as follows: RCS (42%), asbestos (20%), chromium (16%), nickel (15%), and PAH (7%). The measurement data cover the time period from 1951 to present. However, only a small portion of measurements (1.4%) were performed prior to 1975. The major contributing countries for personal measurements were Germany (32%), UK (22%), France (14%), and Norway and Canada (both 11%). CONCLUSIONS: ExpoSYN is a unique occupational exposure database with measurements from 18 European countries and Canada covering a time period of >50 years. This database will be used to develop a country-, job-, and time period-specific quantitative JEM. This JEM will enable data-driven quantitative exposure assessment in a multinational pooled analysis of community-based lung cancer case-control studies.
BACKGROUND: SYNERGY is a large pooled analysis of case-control studies on the joint effects of occupational carcinogens and smoking in the development of lung cancer. A quantitative job-exposure matrix (JEM) will be developed to assign exposures to five major lung carcinogens [asbestos, chromium, nickel, polycyclic aromatic hydrocarbons (PAH), and respirable crystalline silica (RCS)]. We assembled an exposure database, called ExpoSYN, to enable such a quantitative exposure assessment. METHODS: Existing exposure databases were identified and European and Canadian research institutes were approached to identify pertinent exposure measurement data. Results of individual air measurements were entered anonymized according to a standardized protocol. RESULTS: The ExpoSYN database currently includes 356 551 measurements from 19 countries. In total, 140 666 personal and 215 885 stationary data points were available. Measurements were distributed over the five agents as follows: RCS (42%), asbestos (20%), chromium (16%), nickel (15%), and PAH (7%). The measurement data cover the time period from 1951 to present. However, only a small portion of measurements (1.4%) were performed prior to 1975. The major contributing countries for personal measurements were Germany (32%), UK (22%), France (14%), and Norway and Canada (both 11%). CONCLUSIONS: ExpoSYN is a unique occupational exposure database with measurements from 18 European countries and Canada covering a time period of >50 years. This database will be used to develop a country-, job-, and time period-specific quantitative JEM. This JEM will enable data-driven quantitative exposure assessment in a multinational pooled analysis of community-based lung cancer case-control studies.
Authors: Jelle Vlaanderen; Lützen Portengen; Joachim Schüz; Ann Olsson; Beate Pesch; Benjamin Kendzia; Isabelle Stücker; Florence Guida; Irene Brüske; Heinz-Erich Wichmann; Dario Consonni; Maria Teresa Landi; Neil Caporaso; Jack Siemiatycki; Franco Merletti; Dario Mirabelli; Lorenzo Richiardi; Per Gustavsson; Nils Plato; Karl-Heinz Jöckel; Wolfgang Ahrens; Hermann Pohlabeln; Adonina Tardón; David Zaridze; John K Field; Andrea 't Mannetje; Neil Pearce; John McLaughlin; Paul Demers; Neonila Szeszenia-Dabrowska; Jolanta Lissowska; Peter Rudnai; Eleonora Fabianova; Rodica Stanescu Dumitru; Vladimir Bencko; Lenka Foretova; Vladimir Janout; Paolo Boffetta; Francesco Forastiere; Bas Bueno-de-Mesquita; Susan Peters; Thomas Brüning; Hans Kromhout; Kurt Straif; Roel Vermeulen Journal: Am J Epidemiol Date: 2013-12-18 Impact factor: 4.897
Authors: Benjamin Kendzia; Beate Pesch; Dorothea Koppisch; Rainer Van Gelder; Katrin Pitzke; Wolfgang Zschiesche; Thomas Behrens; Tobias Weiss; Jack Siemiatycki; Jerome Lavoué; Karl-Heinz Jöckel; Roger Stamm; Thomas Brüning Journal: J Expo Sci Environ Epidemiol Date: 2017-01-18 Impact factor: 5.563
Authors: Susan Peters; Hans Kromhout; Lützen Portengen; Ann Olsson; Benjamin Kendzia; Raymond Vincent; Barbara Savary; Jérôme Lavoué; Domenico Cavallo; Andrea Cattaneo; Dario Mirabelli; Nils Plato; Joelle Fevotte; Beate Pesch; Thomas Brüning; Kurt Straif; Roel Vermeulen Journal: Ann Occup Hyg Date: 2012-07-17
Authors: María Fernanda Cely-García; Frank C Curriero; Mauricio Sánchez-Silva; Patrick N Breysse; Margarita Giraldo; Lorena Méndez; Carlos Torres-Duque; Mauricio Durán; Mauricio González-García; Patricia Parada; Juan Pablo Ramos-Bonilla Journal: J Expo Sci Environ Epidemiol Date: 2016-12-14 Impact factor: 5.563
Authors: Philippe Sarazin; Igor Burstyn; Laurel Kincl; Melissa C Friesen; Jérôme Lavoué Journal: Ann Work Expo Health Date: 2018-03-12 Impact factor: 2.179
Authors: Martie van Tongeren; Laurel Kincl; Lesley Richardson; Geza Benke; Jordi Figuerola; Timo Kauppinen; Ramzan Lakhani; Jérôme Lavoué; Dave McLean; Nils Plato; Elisabeth Cardis Journal: Ann Occup Hyg Date: 2013-03-06