OBJECTIVE: To report changes of cerebral blood flow and metabolism associated with status epilepticus after cardiac arrest. DESIGN: Case report. SETTING: Neurological intensive care unit in a university hospital. PATIENT: An 85-year-old man resuscitated from out-of-hospital cardiac arrest underwent brain multimodality monitoring and treatment with therapeutic hypothermia. MAIN OUTCOME MEASURES: Changes of cerebral blood flow and metabolism. RESULTS: Repetitive electrographic seizure activity detected at the start of monitoring was associated with dramatic reductions in brain tissue oxygen tension and striking surges in cerebral blood flow and brain temperature. Intravenous lorazepam and levetiracetam administration resulted in immediate cessation of the seizures and these associated derangements. The lactate to pyruvate ratio was initially elevated and trended down after administration of anticonvulsants. CONCLUSION: Brain multimodality monitoring is a feasible method for evaluating secondary brain injury associated with seizure activity after cardiac arrest.
OBJECTIVE: To report changes of cerebral blood flow and metabolism associated with status epilepticus after cardiac arrest. DESIGN: Case report. SETTING: Neurological intensive care unit in a university hospital. PATIENT: An 85-year-old man resuscitated from out-of-hospital cardiac arrest underwent brain multimodality monitoring and treatment with therapeutic hypothermia. MAIN OUTCOME MEASURES: Changes of cerebral blood flow and metabolism. RESULTS: Repetitive electrographic seizure activity detected at the start of monitoring was associated with dramatic reductions in brain tissue oxygen tension and striking surges in cerebral blood flow and brain temperature. Intravenous lorazepam and levetiracetam administration resulted in immediate cessation of the seizures and these associated derangements. The lactate to pyruvate ratio was initially elevated and trended down after administration of anticonvulsants. CONCLUSION: Brain multimodality monitoring is a feasible method for evaluating secondary brain injury associated with seizure activity after cardiac arrest.
Authors: Alois J Schiefecker; Mario Kofler; Max Gaasch; Ronny Beer; Iris Unterberger; Bettina Pfausler; Gregor Broessner; Peter Lackner; Paul Rhomberg; Elke Gizewski; Werner O Hackl; Miriam Mulino; Martin Ortler; Claudius Thome; Erich Schmutzhard; Raimund Helbok Journal: J Cereb Blood Flow Metab Date: 2017-04-24 Impact factor: 6.200
Authors: Jan Claassen; Adler Perotte; David Albers; Samantha Kleinberg; J Michael Schmidt; Bin Tu; Neeraj Badjatia; Hector Lantigua; Lawrence J Hirsch; Stephan A Mayer; E Sander Connolly; George Hripcsak Journal: Ann Neurol Date: 2013-06-27 Impact factor: 10.422