ETHNOPHARMACOLOGICAL RELEVANCE: Mesua ferrea Linn. (Cluciaseae), Cobra's saffron, is named after the heaviness of its timber and is cultivated in tropical climates for its form, foliage, and fragrant flowers. It is prescribed in the Ayurvedic literature for the treatment of pain, inflammation, and rheumatic conditions. OBJECTIVE: In present investigation, activity of Mesua ferrea and its evaluation in the formaldehyde and Complete Freund's Adjuvant (CFA)-induced arthritis in rats is reported. MATERIALS AND METHODS: The extracts obtained from successive extraction were subjected to preliminary phytochemical investigation and antiarthritic activity was evaluated by inducing formaldehyde and CFA. Body weight changes and haematological parameters were measured. RESULTS: The results indicate that Mesua ferrea protects rats against formaldehyde and CFA induced arthritis. The body weight changes and haematological perturbations induced by CFA were maintained. The overall results indicated that Mesua ferrea exerts a potent protective effect against formaldehyde and adjuvant-induced arthritis in rats. CONCLUSION: These findings demonstrate that the present study validates the ethnomedicinal use of seeds of Mesua ferrea in the treatment of arthritis conditions.
ETHNOPHARMACOLOGICAL RELEVANCE: Mesua ferrea Linn. (Cluciaseae), Cobra's saffron, is named after the heaviness of its timber and is cultivated in tropical climates for its form, foliage, and fragrant flowers. It is prescribed in the Ayurvedic literature for the treatment of pain, inflammation, and rheumatic conditions. OBJECTIVE: In present investigation, activity of Mesua ferrea and its evaluation in the formaldehyde and Complete Freund's Adjuvant (CFA)-induced arthritis in rats is reported. MATERIALS AND METHODS: The extracts obtained from successive extraction were subjected to preliminary phytochemical investigation and antiarthritic activity was evaluated by inducing formaldehyde and CFA. Body weight changes and haematological parameters were measured. RESULTS: The results indicate that Mesua ferrea protects rats against formaldehyde and CFA induced arthritis. The body weight changes and haematological perturbations induced by CFA were maintained. The overall results indicated that Mesua ferrea exerts a potent protective effect against formaldehyde and adjuvant-induced arthritis in rats. CONCLUSION: These findings demonstrate that the present study validates the ethnomedicinal use of seeds of Mesua ferrea in the treatment of arthritis conditions.
Authors: Maryam Farrukh; Uzma Saleem; Muhammad Qasim; Maria Manan; Muhammad Ajmal Shah Journal: Inflammopharmacology Date: 2022-02-26 Impact factor: 4.473
Authors: Tri Nhut Pham; Xuan Tuyen Nguyen; Trong Doan Phan; Tien Dung Le; Thi Bach Tuyet Nguyen; Thi Phuong Lien Hoang; Long Giang Bach Journal: Heliyon Date: 2022-02-18
Authors: Mater Hussen Mahnashi; Zeeshan Jabbar; Hafiz Muhammad Irfan; Mulazim Hussain Asim; Muhammad Akram; Ahmed Saif; Mohammed Abdulrahman Alshahrani; Mohammed Ali Alshehri; Saeed Ahmed Asiri Journal: Inflammopharmacology Date: 2021-07-24 Impact factor: 4.473
Authors: Soek Sin Teh; Gwendoline Cheng Lian Ee; Siau Hui Mah; Yoke Keong Yong; Yang Mooi Lim; Mawardi Rahmani; Zuraini Ahmad Journal: Biomed Res Int Date: 2013-09-08 Impact factor: 3.411