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Literature DB >> 21983155

Antibody responses and cross protection against lethal influenza A viruses differ between the sexes in C57BL/6 mice.

Maria E Lorenzo¹, Andrea Hodgson, Dionne P Robinson, Jenifer B Kaplan, Andrew Pekosz, Sabra L Klein.

Abstract

A mouse model was used to determine if protective immunity to influenza A virus infection differs between the sexes. The median lethal dose of H1N1 or H3N2 was lower for naïve females than males. After a sublethal, primary infection with H1N1 or H3N2, females and males showed a similar transient morbidity, but females generated more neutralizing and total anti-influenza A virus antibodies. Immunized males and females showed similar protection against secondary challenge with a homologous virus, but males experienced greater morbidity and had higher lung viral titers after infection with a lethal dose of heterologous virus. Females develop stronger humoral immune responses and greater cross protection against heterosubtypic virus challenge. Copyright Â

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Year: 2011 PMID： 21983155 PMCID： PMC3206291 DOI： 10.1016/j.vaccine.2011.09.110

Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641

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Review 1. Sex-associated hormones and immunity to protozoan parasites.

Authors: C W Roberts; W Walker; J Alexander
Journal: Clin Microbiol Rev Date: 2001-07 Impact factor: 26.132

2. Gamma interferon is not required for mucosal cytotoxic T-lymphocyte responses or heterosubtypic immunity to influenza A virus infection in mice.

Authors: H H Nguyen; F W van Ginkel; H L Vu; M J Novak; J R McGhee; J Mestecky
Journal: J Virol Date: 2000-06 Impact factor: 5.103

3. Risk of severe outcomes among patients admitted to hospital with pandemic (H1N1) influenza.

Authors: Alexia Campbell; Rachel Rodin; Rhonda Kropp; Yang Mao; Zhiyong Hong; Julie Vachon; John Spika; Louise Pelletier
Journal: CMAJ Date: 2010-02-16 Impact factor: 8.262

Review 4. Structural basis of immune recognition of influenza virus hemagglutinin.

Authors: I A Wilson; N J Cox
Journal: Annu Rev Immunol Date: 1990 Impact factor: 28.527

5. Human antibodies reveal a protective epitope that is highly conserved among human and nonhuman influenza A viruses.

Authors: Andres G Grandea; Ole A Olsen; Thomas C Cox; Mark Renshaw; Philip W Hammond; Po-Ying Chan-Hui; Jennifer L Mitcham; Witold Cieplak; Shaun M Stewart; Michael L Grantham; Andrew Pekosz; Maki Kiso; Kyoko Shinya; Masato Hatta; Yoshihiro Kawaoka; Matthew Moyle
Journal: Proc Natl Acad Sci U S A Date: 2010-07-01 Impact factor: 11.205

6. 17β-Estradiol restores antibody responses to an influenza vaccine in a postmenopausal mouse model.

Authors: Doan C Nguyen; Feda Masseoud; Xiuhua Lu; Franco Scinicariello; Suryaprakash Sambhara; Roberta Attanasio
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7. Primary influenza A virus infection induces cross-protective immunity against a lethal infection with a heterosubtypic virus strain in mice.

Authors: J H C M Kreijtz; R Bodewes; G van Amerongen; T Kuiken; R A M Fouchier; A D M E Osterhaus; G F Rimmelzwaan
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8. Evidence of a cross-protective immune response to influenza A in the cotton rat model.

Authors: Timothy M Straight; Martin G Ottolini; Gregory A Prince; Maryna C Eichelberger
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9. Evaluation of live and inactivated influenza A virus vaccines in a mouse model.

Authors: D Armerding; H Rossiter; I Ghazzouli; E Liehl
Journal: J Infect Dis Date: 1982-03 Impact factor: 5.226

10. Sex-associated differences in the regulation of immune responses controlled by the MHC of the mouse.

Authors: Y Weinstein; S Ran; S Segal
Journal: J Immunol Date: 1984-02 Impact factor: 5.422

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10. 17β-estradiol protects females against influenza by recruiting neutrophils and increasing virus-specific CD8 T cell responses in the lungs.

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