Literature DB >> 6977595

Evaluation of live and inactivated influenza A virus vaccines in a mouse model.

D Armerding, H Rossiter, I Ghazzouli, E Liehl.   

Abstract

Induction of cross-protective immunity against serologically distinct subtypes of influenza A virus in mice was examined in an attempt to correlate cross-protection with heterotypic lymphocyte responses. Live and inactivated virus vaccines protected against the homologous subtype, but only whole virus protected against heterologous subtypes. Live virus vaccines provided better cross-protection than inactivated virus vaccines. A weak defense against heterotypic challenge generated by live H0N1 virus could be boosted by cross-stimulation with whole H3N2 virus and by restimulation with pathogenic H0N1 virus. Heterotypic protection persisted for at least five months. Live viruses induced cross-reactive cytotoxic T cells in normal mice. However, cross-stimulation with heterologous virus was required to generate secondary cytotoxicity. Cross-reactive B lymphocytes were evident after inoculation with whole virus.

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Year:  1982        PMID： 6977595     DOI： 10.1093/infdis/145.3.320

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  18 in total

1.  Evaluation of replication and cross-reactive antibody responses of H2 subtype influenza viruses in mice and ferrets.

Authors:  Grace L Chen; Elaine W Lamirande; Chin-Fen Yang; Hong Jin; George Kemble; Kanta Subbarao
Journal:  J Virol       Date:  2010-05-26       Impact factor: 5.103

2.  Live attenuated influenza vaccine (LAIV) impacts innate and adaptive immune responses.

Authors:  Paula A Lanthier; Gail E Huston; Amy Moquin; Sheri M Eaton; Frank M Szaba; Lawrence W Kummer; Micheal P Tighe; Jacob E Kohlmeier; Patrick J Blair; Michael Broderick; Stephen T Smiley; Laura Haynes
Journal:  Vaccine       Date:  2011-08-02       Impact factor: 3.641

3.  Comparison of a live attenuated 2009 H1N1 vaccine with seasonal influenza vaccines against 2009 pandemic H1N1 virus infection in mice and ferrets.

Authors:  Grace L Chen; Ji-Young Min; Elaine W Lamirande; Celia Santos; Hong Jin; George Kemble; Kanta Subbarao
Journal:  J Infect Dis       Date:  2011-01-21       Impact factor: 5.226

4.  Antibody responses and cross protection against lethal influenza A viruses differ between the sexes in C57BL/6 mice.

Authors:  Maria E Lorenzo; Andrea Hodgson; Dionne P Robinson; Jenifer B Kaplan; Andrew Pekosz; Sabra L Klein
Journal:  Vaccine       Date:  2011-10-06       Impact factor: 3.641

5.  Immunity to the conserved influenza nucleoprotein reduces susceptibility to secondary bacterial infections.

Authors:  Laura Haynes; Frank M Szaba; Sheri M Eaton; Lawrence W Kummer; Paula A Lanthier; Ashlee H Petell; Debra K Duso; Deyan Luo; Jr-Shiuan Lin; Julie S Lefebvre; Troy D Randall; Lawrence L Johnson; Jacob E Kohlmeier; David L Woodland; Stephen T Smiley
Journal:  J Immunol       Date:  2012-10-01       Impact factor: 5.422

6.  Killer T cell responses to influenza A during a drift period: studies in mice.

Authors:  D Armerding; H Rossiter; E Liehl
Journal:  Med Microbiol Immunol       Date:  1982       Impact factor: 3.402

7.  Intranasal immunization with inactivated influenza virus enhances immune responses to coadministered simian-human immunodeficiency virus-like particle antigens.

Authors:  Sang-Moo Kang; Lizheng Guo; Qizhi Yao; Ioanna Skountzou; Richard W Compans
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103

8.  Induction of cytotoxic T-lymphocyte and antibody responses against highly pathogenic avian influenza virus infection in mice by inoculation of apathogenic H5N1 influenza virus particles inactivated with formalin.

Authors:  Toshihiro Sawai; Yasushi Itoh; Hiroichi Ozaki; Norikazu Isoda; Kiyoko Okamoto; Yoshitaka Kashima; Yoshihiro Kawaoka; Yoshihiro Takeuchi; Hiroshi Kida; Kazumasa Ogasawara
Journal:  Immunology       Date:  2008-01-16       Impact factor: 7.397

9.  Induction of heterosubtypic immunity to influenza virus by intranasal immunization.

Authors:  Fu-Shi Quan; Richard W Compans; Huan H Nguyen; Sang-Moo Kang
Journal:  J Virol       Date:  2007-11-21       Impact factor: 5.103

10.  Cross-protection by co-immunization with influenza hemagglutinin DNA and inactivated virus vaccine using coated microneedles.

Authors:  Yeu-Chun Kim; Dae-Goon Yoo; Richard W Compans; Sang-Moo Kang; Mark R Prausnitz
Journal:  J Control Release       Date:  2013-04-30       Impact factor: 9.776
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