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Literature DB >> 21971560

Novel glutamatergic agents for major depressive disorder and bipolar disorder.

Rodrigo Machado-Vieira¹, Lobna Ibrahim, Ioline D Henter, Carlos A Zarate.

Abstract

Mood disorders such as major depressive disorder (MDD) and bipolar disorder (BPD) are common, chronic, recurrent mental illnesses that affect the lives and functioning of millions of individuals worldwide. Growing evidence suggests that the glutamatergic system is central to the neurobiology and treatment of these disorders. Here, we review data supporting the involvement of the glutamatergic system in the pathophysiology of mood disorders as well as the efficacy of glutamatergic agents as novel therapeutics. Published by Elsevier Inc.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：
Receptors, Glutamate

Year: 2011 PMID： 21971560 PMCID： PMC3253881 DOI： 10.1016/j.pbb.2011.09.010

Source DB: PubMed Journal: Pharmacol Biochem Behav ISSN： 0091-3057 Impact factor: 3.533

175 in total

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Journal: Neuron Date: 2002-07-18 Impact factor: 17.173

2. 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity.

Authors: Nicholas D P Cosford; Lida Tehrani; Jeffrey Roppe; Edwin Schweiger; Nicholas D Smith; Jeffrey Anderson; Linda Bristow; Jesse Brodkin; Xiaohui Jiang; Ian McDonald; Sara Rao; Mark Washburn; Mark A Varney
Journal: J Med Chem Date: 2003-01-16 Impact factor: 7.446

3. Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac).

Authors: Per Svenningsson; Eleni T Tzavara; Jeffrey M Witkin; Allen A Fienberg; George G Nomikos; Paul Greengard
Journal: Proc Natl Acad Sci U S A Date: 2002-03-05 Impact factor: 11.205

4. Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats.

Authors: J M Wieronska; B Szewczyk; P Branski; A Palucha; A Pilc
Journal: Amino Acids Date: 2002 Impact factor: 3.520

5. Age-related changes in the protein expression of subunits of the NMDA receptor.

Authors: Kathy Ruth Magnusson; Scott Edward Nelson; Anne B Young
Journal: Brain Res Mol Brain Res Date: 2002-02-28

6. The long-term natural history of the weekly symptomatic status of bipolar I disorder.

Authors: Lewis L Judd; Hagop S Akiskal; Pamela J Schettler; Jean Endicott; Jack Maser; David A Solomon; Andrew C Leon; John A Rice; Martin B Keller
Journal: Arch Gen Psychiatry Date: 2002-06

7. Striatal excitatory amino acid transporter transcript expression in schizophrenia, bipolar disorder, and major depressive disorder.

Authors: Robert E McCullumsmith; James H Meador-Woodruff
Journal: Neuropsychopharmacology Date: 2002-03 Impact factor: 7.853

Review 8. Roles and regulation of glutamate transporters in the central nervous system.

Authors: R D O'Shea
Journal: Clin Exp Pharmacol Physiol Date: 2002-11 Impact factor: 2.557

9. Small-dose ketamine improves the postoperative state of depressed patients.

Authors: Akira Kudoh; Yoko Takahira; Hiroshi Katagai; Tomoko Takazawa
Journal: Anesth Analg Date: 2002-07 Impact factor: 5.108

10. Riluzole enhances expression of brain-derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampus.

Authors: Ritsuko Katoh-Semba; Tomiko Asano; Hiroshi Ueda; Rika Morishita; Ikuo K Takeuchi; Yutaka Inaguma; Kanefusa Kato
Journal: FASEB J Date: 2002-06-21 Impact factor: 5.191

37 in total

Review 1. New targets for rapid antidepressant action.

Authors: Rodrigo Machado-Vieira; Ioline D Henter; Carlos A Zarate
Journal: Prog Neurobiol Date: 2015-12-23 Impact factor: 11.685

Review 2. Multiple levels of impaired neural plasticity and cellular resilience in bipolar disorder: developing treatments using an integrated translational approach.

Authors: Rodrigo Machado-Vieira; Marcio G Soeiro-De-Souza; Erica M Richards; Antonio L Teixeira; Carlos A Zarate
Journal: World J Biol Psychiatry Date: 2013-09-02 Impact factor: 4.132

3. Antidepressant-like effects induced by NMDA receptor blockade and NO synthesis inhibition in the ventral medial prefrontal cortex of rats exposed to the forced swim test.

Authors: Vitor Silva Pereira; Angélica Romano; Gregers Wegener; Sâmia R L Joca
Journal: Psychopharmacology (Berl) Date: 2015-01-16 Impact factor: 4.530

4. A Double-Blind, Placebo-Controlled, Pilot Study of Riluzole Monotherapy for Acute Bipolar Depression.

Authors: Lawrence T Park; Marc S Lener; Matthew Hopkins; Nicolas Iadorola; Rodrigo Machado-Vieira; Elizabeth Ballard; Allison Nugent; Carlos A Zarate
Journal: J Clin Psychopharmacol Date: 2017-06 Impact factor: 3.153

5. Course of improvement in depressive symptoms to a single intravenous infusion of ketamine vs add-on riluzole: results from a 4-week, double-blind, placebo-controlled study.

Authors: Lobna Ibrahim; Nancy Diazgranados; Jose Franco-Chaves; Nancy Brutsche; Ioline D Henter; Phillip Kronstein; Ruin Moaddel; Irving Wainer; David A Luckenbaugh; Husseini K Manji; Carlos A Zarate
Journal: Neuropsychopharmacology Date: 2012-02-01 Impact factor: 7.853

6. Cerebrospinal fluid glutamate concentration correlates with impulsive aggression in human subjects.

Authors: Emil F Coccaro; Royce Lee; Paul Vezina
Journal: J Psychiatr Res Date: 2013-06-18 Impact factor: 4.791

7. Investigation of Heschl's gyrus and planum temporale in patients with schizophrenia and bipolar disorder: a proton magnetic resonance spectroscopy study.

Authors: M I Atagün; E M Şıkoğlu; S S Can; G Karakaş-Uğurlu; S Ulusoy-Kaymak; A Çayköylü; O Algın; M L Phillips; C M Moore; D Öngür
Journal: Schizophr Res Date: 2014-12-03 Impact factor: 4.939