Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats.

Literature DB >> 12373540

Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats.

J M Wieronska¹, B Szewczyk, P Branski, A Palucha, A Pilc.

Abstract

Using the olfactory bulbectomy model of depression, we examined the antidepressant-like activity of 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats. Bulbectomized rats required a significantly greater number of trials to acquire the response similar to sham-operated controls in the passive avoidance model. Both the prolonged (but not acute) treatment with MPEP and with antidepressant drug-desipramine restored the learning deficit. The results indicate that the prolonged blockade of mGlu5 receptors exerts antidepressant-like effects in rats.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2002 PMID： 12373540 DOI： 10.1007/s00726-001-0131-5

Source DB: PubMed Journal: Amino Acids ISSN： 0939-4451 Impact factor: 3.520

Keyword Cloud
Cited

18 in total

1. In vivo positron emission tomography imaging with [¹¹C]ABP688: binding variability and specificity for the metabotropic glutamate receptor subtype 5 in baboons.

Authors: Christine DeLorenzo; Matthew S Milak; Kathleen G Brennan; J S Dileep Kumar; J John Mann; Ramin V Parsey
Journal: Eur J Nucl Med Mol Imaging Date: 2011-01-29 Impact factor: 9.236

2. Activation of the mGlu7 receptor elicits antidepressant-like effects in mice.

Authors: Agnieszka Palucha; Kinga Klak; Piotr Branski; Herman van der Putten; Peter J Flor; Andrzej Pilc
Journal: Psychopharmacology (Berl) Date: 2007-07-12 Impact factor: 4.530

Review 3. Metabotropic Glutamate Receptor 5 as a Target for the Treatment of Depression and Smoking: Robust Preclinical Data but Inconclusive Clinical Efficacy.

Authors: Samuel A Barnes; Douglas J Sheffler; Svetlana Semenova; Nicholas D P Cosford; Anton Bespalov
Journal: Biol Psychiatry Date: 2018-03-09 Impact factor: 13.382

Review 4. Proof of concept trials in bipolar disorder and major depressive disorder: a translational perspective in the search for improved treatments.

Authors: Rodrigo Machado-Vieira; Carlos A Zarate
Journal: Depress Anxiety Date: 2011-02-24 Impact factor: 6.505

Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats.

1. In vivo positron emission tomography imaging with [¹¹C]ABP688: binding variability and specificity for the metabotropic glutamate receptor subtype 5 in baboons.

2. Activation of the mGlu7 receptor elicits antidepressant-like effects in mice.

Review 3. Metabotropic Glutamate Receptor 5 as a Target for the Treatment of Depression and Smoking: Robust Preclinical Data but Inconclusive Clinical Efficacy.

Review 4. Proof of concept trials in bipolar disorder and major depressive disorder: a translational perspective in the search for improved treatments.

Review 5. Allosteric modulation of metabotropic glutamate receptors.

Review 6. Targeting glutamatergic signaling for the development of novel therapeutics for mood disorders.

7. On the mechanism of the antidepressant-like action of group II mGlu receptor antagonist, MGS0039.

Review 8. Bipolar disorder: candidate drug targets.

Review 9. The role of the tripartite glutamatergic synapse in the pathophysiology and therapeutics of mood disorders.

10. Alterations in mGlu5 receptor expression and function in the striatum in a rat depression model.