BACKGROUND: Hemispherical asymmetry, sex differences and age-related changes have been reported for the human brain. Meanwhile it was still unclear the presence of the asymmetry or sex differences in the human brain occurred whether as a normal development or as consequences of any pathological changes. The aim of this study was to investigate hemispherical asymmetry, sex differences and age-related changes by using a tract-based analysis in the nerve bundles. METHODS: 40 healthy elderly subjects underwent magnetic resonance diffusion tensor imaging, and we calculated fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values along the major white matter bundles. RESULTS: We identified hemispherical asymmetry in the ADC values for the cingulate fasciculus in the total subject set and in males, and a sex difference in the FA values for the right uncinate fasciculus. For age-related changes, we demonstrated a significant increase in ADC values with advancing age in the right cingulum, left temporal white matter, and a significant decrease in FA values in the right superior longitudinal fasciculus. CONCLUSION: In this study, we found hemispherical asymmetry, sex differences and age-related changes in particular regions of the white matter in the healthy elderly. Our results suggest considering these differences can be important in imaging studies.
BACKGROUND: Hemispherical asymmetry, sex differences and age-related changes have been reported for the human brain. Meanwhile it was still unclear the presence of the asymmetry or sex differences in the human brain occurred whether as a normal development or as consequences of any pathological changes. The aim of this study was to investigate hemispherical asymmetry, sex differences and age-related changes by using a tract-based analysis in the nerve bundles. METHODS: 40 healthy elderly subjects underwent magnetic resonance diffusion tensor imaging, and we calculated fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values along the major white matter bundles. RESULTS: We identified hemispherical asymmetry in the ADC values for the cingulate fasciculus in the total subject set and in males, and a sex difference in the FA values for the right uncinate fasciculus. For age-related changes, we demonstrated a significant increase in ADC values with advancing age in the right cingulum, left temporal white matter, and a significant decrease in FA values in the right superior longitudinal fasciculus. CONCLUSION: In this study, we found hemispherical asymmetry, sex differences and age-related changes in particular regions of the white matter in the healthy elderly. Our results suggest considering these differences can be important in imaging studies.
Authors: T Taoka; S Iwasaki; M Sakamoto; H Nakagawa; A Fukusumi; K Myochin; S Hirohashi; T Hoshida; K Kichikawa Journal: AJNR Am J Neuroradiol Date: 2006-05 Impact factor: 3.825
Authors: H Sawada; F Udaka; Y Izumi; K Nishinaka; H Kawakami; S Nakamura; M Kameyama Journal: J Neurol Neurosurg Psychiatry Date: 2000-05 Impact factor: 10.154
Authors: Philip R Szeszko; Joshua Vogel; Manzar Ashtari; Anil K Malhotra; John Bates; John M Kane; Robert M Bilder; Theresa Frevert; Kelvin Lim Journal: Neuroreport Date: 2003-12-19 Impact factor: 1.837
Authors: Philip R Szeszko; Ek Tsoon Tan; Aziz M Uluğ; Peter B Kingsley; Juan A Gallego; Kathryn Rhindress; Anil K Malhotra; Delbert G Robinson; Luca Marinelli Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2017-10-28 Impact factor: 5.067
Authors: Johanna Seitz; Suheyla Cetin-Karayumak; Amanda Lyall; Ofer Pasternak; Madhura Baxi; Mark Vangel; Godfrey Pearlson; Carol Tamminga; John Sweeney; Brett Clementz; David Schretlen; Petra Verena Viher; Katharina Stegmayer; Sebastian Walther; Jungsun Lee; Tim Crow; Anthony James; Aristotle Voineskos; Robert W Buchanan; Philip R Szeszko; Anil Malhotra; Matcheri Keshavan; Inga K Koerte; Martha E Shenton; Yogesh Rathi; Marek Kubicki Journal: Cereb Cortex Date: 2021-01-01 Impact factor: 5.357