PURPOSE: The aims of this study were to systematically review the medical literature, in order to find controlled studies about microfracture in the treatment of patients with full-thickness cartilage lesions of the knee, to statistically combine these studies in order to determine a best estimate of the average treatment effect, and to gather information to detect cartilage-specific and patient-specific factors that might have an influence on the clinical outcome. METHODS: We searched four electronic databases for controlled clinical trials or controlled prospective observational studies. We pooled before/after-data of study arms using the term microfracture. RESULTS: We calculated an overall best estimate of 1.106, with [0.566; 1.646] as 95% confidence interval of the mean standardized treatment effect for a representative patient population. CONCLUSIONS: Our meta-analysis revealed a clinically relevant improvement of the postoperative clinical status as compared to the preoperative status. An increase of 22 overall KOOS points may provide a rough estimate for the mean expected treatment effect achieved by microfracturing.
PURPOSE: The aims of this study were to systematically review the medical literature, in order to find controlled studies about microfracture in the treatment of patients with full-thickness cartilage lesions of the knee, to statistically combine these studies in order to determine a best estimate of the average treatment effect, and to gather information to detect cartilage-specific and patient-specific factors that might have an influence on the clinical outcome. METHODS: We searched four electronic databases for controlled clinical trials or controlled prospective observational studies. We pooled before/after-data of study arms using the term microfracture. RESULTS: We calculated an overall best estimate of 1.106, with [0.566; 1.646] as 95% confidence interval of the mean standardized treatment effect for a representative patient population. CONCLUSIONS: Our meta-analysis revealed a clinically relevant improvement of the postoperative clinical status as compared to the preoperative status. An increase of 22 overall KOOS points may provide a rough estimate for the mean expected treatment effect achieved by microfracturing.
Authors: P C Kreuz; M R Steinwachs; C Erggelet; S J Krause; G Konrad; M Uhl; N Südkamp Journal: Osteoarthritis Cartilage Date: 2006-07-11 Impact factor: 6.576
Authors: D D Frisbie; G W Trotter; B E Powers; W G Rodkey; J R Steadman; R D Howard; R D Park; C W McIlwraith Journal: Vet Surg Date: 1999 Jul-Aug Impact factor: 1.495
Authors: Turgay Efe; Alexander Füglein; Alan Getgood; Thomas J Heyse; Susanne Fuchs-Winkelmann; Thilo Patzer; Bilal F El-Zayat; Stefan Lakemeier; Markus D Schofer Journal: Int Orthop Date: 2011-12-06 Impact factor: 3.075
Authors: Marco Pellegrino; Ermanno Trinchese; Michele Bisaccia; Giuseppe Rinonapoli; Luigi Meccariello; Gabriele Falzarano; Antonio Medici; Luigi Piscitelli; Pellegrino Ferrara; Auro Caraffa Journal: Clin Cases Miner Bone Metab Date: 2017-02-10
Authors: Alexander Beletsky; Neal B Naveen; Tracy Tauro; Taylor M Southworth; Jorge Chahla; Nikhil N Verma; Adam B Yanke; Brian J Cole Journal: Arthrosc Sports Med Rehabil Date: 2021-04-06