Literature DB >> 25405097

Treatment for cartilage injuries of the knee with a new treatment algorithm.

Ahmet Ozmeriç1, Kadir Bahadır Alemdaroğlu1, Nevres Hürriyet Aydoğan1.   

Abstract

Treatment of articular cartilage injuries to the knee remains a considerable challenge today. Current procedures succeed in providing relief of symptoms, however damaged articular tissue is not replaced with new tissue of the same biomechanical properties and long-term durability as normal hyaline cartilage. Despite many arthroscopic procedures that often manage to achieve these goals, results are far from perfect and there is no agreement on which of these procedures are appropriate, particularly when full-thickness chondral defects are considered.Therefore, the search for biological solution in long-term functional healing and increasing the quality of wounded cartilage has been continuing. For achieving this goal and apply in wide defects, scaffolds are developed.The rationale of using a scaffold is to create an environment with biodegradable polymers for the in vitro growth of living cells and their subsequent implantation into the lesion area. Previously a few numbers of surgical treatment algorithm was described in reports, however none of them contained one-step or two -steps scaffolds. The ultimate aim of this article was to review various arthroscopic treatment options for different stage lesions and develop a new treatment algorithm which included the scaffolds.

Entities:  

Keywords:  Autologous chondrocyte implantation; Chondral lesion; Microfracture; Osteochondral transplantation; Scaffolds

Year:  2014        PMID: 25405097      PMCID: PMC4133476          DOI: 10.5312/wjo.v5.i5.677

Source DB:  PubMed          Journal:  World J Orthop        ISSN: 2218-5836


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  13 in total

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Journal:  Acta Biomed       Date:  2022-08-31

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Authors:  Per-Henrik Randsborg; Asbjørn Årøen; Christian Owesen
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Authors:  Ketansinh Solanki; Saseendar Shanmugasundaram; Neha Shetty; Seok-Jung Kim
Journal:  J Clin Orthop Trauma       Date:  2021-09-21

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Review 6.  Microfracture is more cost-effective than autologous chondrocyte implantation: a review of level 1 and level 2 studies with 5 year follow-up.

Authors:  Tommy Frøseth Aae; Per-Henrik Randsborg; Hilde Lurås; Asbjørn Årøen; Øystein Bjerkestrand Lian
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7.  Norwegican Cartilage Project - a study protocol for a double-blinded randomized controlled trial comparing arthroscopic microfracture with arthroscopic debridement in focal cartilage defects in the knee.

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8.  Focal cartilage defects in the knee - a randomized controlled trial comparing autologous chondrocyte implantation with arthroscopic debridement.

Authors:  Per-Henrik Randsborg; Jan Brinchmann; Sverre Løken; Heidi Andreassen Hanvold; Tommy Frøseth Aae; Asbjørn Årøen
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9.  Healing of Osteochondral Defects Implanted with Biomimetic Scaffolds of Poly(ε-Caprolactone)/Hydroxyapatite and Glycidyl-Methacrylate-Modified Hyaluronic Acid in a Minipig.

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10.  AUTOLOGOUS CHONDROCYTE IMPLANTATION IN BRAZIL.

Authors:  Pedro Nogueira Giglio; Nelson Foresto Lizier; Débora Levy; Marcel Faraco Sobrado; Riccardo Gomes Gobbi; José Ricardo Pécora; Sergio Paulo Bydlowski; Marco Kawamura Demange
Journal:  Acta Ortop Bras       Date:  2020 May-Jun       Impact factor: 0.513

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