Literature DB >> 21968646

Reduced susceptibility of Moritella profunda dihydrofolate reductase to trimethoprim is not due to glutamate 28.

E Joel Loveridge1, William M Dawson, Rhiannon M Evans, Anna Sobolewska, Rudolf K Allemann.   

Abstract

The E28D variant of dihydrofolate reductase from Moritella profunda was generated and found to have the same K (i) (within error) for the competitive inhibitor trimethoprim as the wild type enzyme. Contrary to a previous claim in the literature, Glu 28 is therefore not the cause of the reduced affinity for trimethoprim relative to dihydrofolate reductase from Escherichia coli.

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Year:  2011        PMID： 21968646     DOI： 10.1007/s10930-011-9361-x

Source DB:  PubMed          Journal:  Protein J        ISSN： 1572-3887            Impact factor:   2.371


  13 in total

1.  Catalysis by dihydrofolate reductase from the psychropiezophile Moritella profunda.

Authors:  Rhiannon M Evans; Enas M Behiry; Lai-Hock Tey; Jiannan Guo; E Joel Loveridge; Rudolf K Allemann
Journal:  Chembiochem       Date:  2010-09-24       Impact factor: 3.164

2.  Directed evolution of trimethoprim resistance in Escherichia coli.

Authors:  Morgan Watson; Jian-Wei Liu; David Ollis
Journal:  FEBS J       Date:  2007-04-19       Impact factor: 5.542

3.  Are the catalytic properties of enzymes from piezophilic organisms pressure adapted?

Authors:  Sam Hay; Rhiannon M Evans; Colin Levy; E Joel Loveridge; Xi Wang; David Leys; Rudolf K Allemann; Nigel S Scrutton
Journal:  Chembiochem       Date:  2009-09-21       Impact factor: 3.164

4.  Characterization of dihydrofolate reductase genes from trimethoprim-susceptible and trimethoprim-resistant strains of Enterococcus faecalis.

Authors:  T M Coque; K V Singh; G M Weinstock; B E Murray
Journal:  Antimicrob Agents Chemother       Date:  1999-01       Impact factor: 5.191

Review 5.  Inhibition of folate biosynthesis and function as a basis for chemotherapy.

Authors:  G H Hitchings; J J Burchall
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1965

Review 6.  Trimethoprim and sulfonamide resistance.

Authors:  P Huovinen; L Sundström; G Swedberg; O Sköld
Journal:  Antimicrob Agents Chemother       Date:  1995-02       Impact factor: 5.191

7.  Moritella cold-active dihydrofolate reductase: are there natural limits to optimization of catalytic efficiency at low temperature?

Authors:  Ying Xu; Georges Feller; Charles Gerday; Nicolas Glansdorff
Journal:  J Bacteriol       Date:  2003-09       Impact factor: 3.490

8.  Mechanism of inhibition of dihydrofolate reductases from bacterial and vertebrate sources by various classes of folate analogues.

Authors:  S R Stone; J F Morrison
Journal:  Biochim Biophys Acta       Date:  1986-02-14

9.  Cloning and characterization of dihydrofolate reductases from deep-sea bacteria.

Authors:  Chiho Murakami; Eiji Ohmae; Shin-Ichi Tate; Kunihiko Gekko; Kaoru Nakasone; Chiaki Kato
Journal:  J Biochem       Date:  2009-12-29       Impact factor: 3.387

10.  Kinetic mechanism of the reaction catalyzed by dihydrofolate reductase from Escherichia coli.

Authors:  S R Stone; J F Morrison
Journal:  Biochemistry       Date:  1982-08-03       Impact factor: 3.162
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  1 in total

1.  Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens.

Authors:  Jolanta Krucinska; Michael N Lombardo; Heidi Erlandsen; Alexavier Estrada; Debjani Si; Kishore Viswanathan; Dennis L Wright
Journal:  Commun Biol       Date:  2022-05-13
  1 in total

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