| Literature DB >> 21965274 |
Catherine S Healey1, Shahana Ahmed, Tracy A O'Mara, Kaltin Ferguson, Diether Lambrechts, Diego A Garcia-Dios, Ignace Vergote, Frederic Amant, Kimberley Howarth, Maggie Gorman, Shirley Hodgson, Ian Tomlinson, Hannah P Yang, Jolanta Lissowska, Louise A Brinton, Stephen Chanock, Montserrat Garcia-Closas, Per Hall, Jianjun Liu, Mitul Shah, Paul D P Pharoah, Deborah J Thompson, Timothy R Rebbeck, Brian L Strom, Alison M Dunning, Douglas F Easton, Amanda B Spurdle.
Abstract
Recent large--scale association studies, both of genome-wide and candidate gene design, have revealed several single-nucleotide polymorphisms (SNPs) which are significantly associated with risk of developing breast cancer. As both breast and endometrial cancers are considered to be hormonally driven and share multiple risk factors, we investigated whether breast cancer risk alleles are also associated with endometrial cancer risk. We genotyped nine breast cancer risk SNPs in up to 4188 endometrial cases and 11,928 controls, from between three and seven Caucasian populations. None of the tested SNPs showed significant evidence of association with risk of endometrial cancer.Entities:
Mesh：
Year: 2011 PMID： 21965274 PMCID： PMC3220608 DOI： 10.1093/carcin/bgr214
Source DB: PubMed Journal: Carcinogenesis ISSN： 0143-3334 Impact factor: 4.944