Literature DB >> 21963299

mTOR signaling in disease.

Eva Dazert1, Michael N Hall.   

Abstract

The target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in response to nutrients, growth factors and cellular energy. Dysregulated mTOR signaling has been implicated in major disease. Here we review recent findings on the role of mTOR in cancer, metabolic disorders, neurological diseases, and inflammation.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21963299     DOI： 10.1016/j.ceb.2011.09.003

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  196 in total

Review 1.  Regulation of TOR by small GTPases.

Authors:  Raúl V Durán; Michael N Hall
Journal:  EMBO Rep       Date:  2012-02-01       Impact factor: 8.807

Review 2.  mTOR in health and in sickness.

Authors:  Dritan Liko; Michael N Hall
Journal:  J Mol Med (Berl)       Date:  2015-09-22       Impact factor: 4.599

3.  Mammalian target of rapamycin controls glucose consumption and redox balance in human Sertoli cells.

Authors:  Tito T Jesus; Pedro F Oliveira; Joaquina Silva; Alberto Barros; Rita Ferreira; Mário Sousa; C Yan Cheng; Branca M Silva; Marco G Alves
Journal:  Fertil Steril       Date:  2015-12-14       Impact factor: 7.329

4.  Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.

Authors:  J Julie Wu; Jie Liu; Edmund B Chen; Jennifer J Wang; Liu Cao; Nisha Narayan; Marie M Fergusson; Ilsa I Rovira; Michele Allen; Danielle A Springer; Cory U Lago; Shuling Zhang; Wendy DuBois; Theresa Ward; Rafael deCabo; Oksana Gavrilova; Beverly Mock; Toren Finkel
Journal:  Cell Rep       Date:  2013-08-29       Impact factor: 9.423

5.  TORC2 is required to maintain genome stability during S phase in fission yeast.

Authors:  Miriam Schonbrun; Masha Kolesnikov; Martin Kupiec; Ronit Weisman
Journal:  J Biol Chem       Date:  2013-05-23       Impact factor: 5.157

6.  AMPKα2 Regulates Bladder Cancer Growth through SKP2-Mediated Degradation of p27.

Authors:  Stavros Kopsiaftis; Katie L Sullivan; Isha Garg; John A Taylor; Kevin P Claffey
Journal:  Mol Cancer Res       Date:  2016-09-16       Impact factor: 5.852

7.  Fibrin supports human fetal islet-epithelial cell differentiation via p70(s6k) and promotes vascular formation during transplantation.

Authors:  Matthew Riopel; Jinming Li; Mark Trinder; George F Fellows; Rennian Wang
Journal:  Lab Invest       Date:  2015-06-01       Impact factor: 5.662

8.  Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis.

Authors:  Xiaojie Xu; Zhongyi Fan; Lei Kang; Juqiang Han; Chengying Jiang; Xiaofei Zheng; Ziman Zhu; Huabo Jiao; Jing Lin; Kai Jiang; Lihua Ding; Hao Zhang; Long Cheng; Hanjiang Fu; Yi Song; Ying Jiang; Jiahong Liu; Rongfu Wang; Nan Du; Qinong Ye
Journal:  J Clin Invest       Date:  2013-01-16       Impact factor: 14.808

9.  Aspirin may inhibit angiogenesis and induce autophagy by inhibiting mTOR signaling pathway in murine hepatocarcinoma and sarcoma models.

Authors:  Qianqian Zhao; Zhaopeng Wang; Zhaoxia Wang; Licun Wu; Weidong Zhang
Journal:  Oncol Lett       Date:  2016-08-16       Impact factor: 2.967

10.  Decreased genetic dosage of hepatic Yin Yang 1 causes diabetic-like symptoms.

Authors:  Francisco Verdeguer; Sharon M Blättler; John T Cunningham; Jessica A Hall; Helen Chim; Pere Puigserver
Journal:  Mol Endocrinol       Date:  2014-01-27
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