Literature DB >> 22240970

Regulation of TOR by small GTPases.

Raúl V Durán1, Michael N Hall.   

Abstract

TOR is a conserved serine/threonine kinase that responds to nutrients, growth factors, the bioenergetic status of the cell and cellular stress to control growth, metabolism and ageing. A diverse group of small GTPases including Rheb, Rag, Rac1, RalA and Ryh1 play a variety of roles in the regulation of TOR. For example, while Rheb binds to and activates TOR directly, Rag and Rac1 regulate its localization and RalA activates it indirectly through the production of phosphatidic acid. Here, we review recent findings on the regulation of TOR by small GTPases.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22240970      PMCID： PMC3271343          DOI： 10.1038/embor.2011.257

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


  90 in total

Review 1.  Rab proteins as membrane organizers.

Authors:  M Zerial; H McBride
Journal:  Nat Rev Mol Cell Biol       Date:  2001-02       Impact factor: 94.444

2.  Elevated phospholipase D activity in H-Ras- but not K-Ras-transformed cells by the synergistic action of RalA and ARF6.

Authors:  Lizhong Xu; Paul Frankel; Desmond Jackson; Thuy Rotunda; Rita L Boshans; Crislyn D'Souza-Schorey; David A Foster
Journal:  Mol Cell Biol       Date:  2003-01       Impact factor: 4.272

3.  Rab small GTPase emerges as a regulator of TOR complex 2.

Authors:  Hisashi Tatebe; Kazuhiro Shiozaki
Journal:  Small GTPases       Date:  2010-11

4.  Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.

Authors:  J Heitman; N R Movva; M N Hall
Journal:  Science       Date:  1991-08-23       Impact factor: 47.728

5.  Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals.

Authors:  W M Yee; P F Worley
Journal:  Mol Cell Biol       Date:  1997-02       Impact factor: 4.272

Review 6.  Amino acid regulation of TOR complex 1.

Authors:  Joseph Avruch; Xiaomeng Long; Sara Ortiz-Vega; Joseph Rapley; Angela Papageorgiou; Ning Dai
Journal:  Am J Physiol Endocrinol Metab       Date:  2008-09-02       Impact factor: 4.310

7.  P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration.

Authors:  Ivette Hernández-Negrete; Jorge Carretero-Ortega; Hans Rosenfeldt; Ricardo Hernández-García; J Victor Calderón-Salinas; Guadalupe Reyes-Cruz; J Silvio Gutkind; José Vázquez-Prado
Journal:  J Biol Chem       Date:  2007-06-12       Impact factor: 5.157

8.  Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin.

Authors:  Alfredo Toschi; Evan Lee; Limei Xu; Avalon Garcia; Noga Gadir; David A Foster
Journal:  Mol Cell Biol       Date:  2008-12-29       Impact factor: 4.272

9.  Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases.

Authors:  Tomohiko Matsuo; Yoshiya Kubo; Yoshinori Watanabe; Masayuki Yamamoto
Journal:  EMBO J       Date:  2003-06-16       Impact factor: 11.598

10.  Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1.

Authors:  Min Zheng; Yan-Hai Wang; Xiao-Nan Wu; Su-Qin Wu; Bao-Ju Lu; Meng-Qiu Dong; Hongbing Zhang; Peiqing Sun; Sheng-Cai Lin; Kun-Liang Guan; Jiahuai Han
Journal:  Nat Cell Biol       Date:  2011-02-20       Impact factor: 28.824
View more
  53 in total

1.  Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade.

Authors:  Juan F Linares; Angeles Duran; Miguel Reina-Campos; Pedro Aza-Blanc; Alex Campos; Jorge Moscat; Maria T Diaz-Meco
Journal:  Cell Rep       Date:  2015-08-13       Impact factor: 9.423

2.  Characterization of the pumpkin Translationally-Controlled Tumor Protein CmTCTP.

Authors:  J Jesús Hinojosa-Moya; Beatriz Xoconostle-Cázares; Roberto Toscano-Morales; Francisco Ramírez-Ortega; José Luis Cabrera-Ponce; Roberto Ruiz-Medrano
Journal:  Plant Signal Behav       Date:  2013-09-24

Review 3.  The autophagosome: origins unknown, biogenesis complex.

Authors:  Christopher A Lamb; Tamotsu Yoshimori; Sharon A Tooze
Journal:  Nat Rev Mol Cell Biol       Date:  2013-11-08       Impact factor: 94.444

4.  γ-Crystallins of the chicken lens: remnants of an ancient vertebrate gene family in birds.

Authors:  Yingwei Chen; Vatsala Sagar; Hoay-Shuen Len; Katherine Peterson; Jianguo Fan; Sanghamitra Mishra; John McMurtry; Phillip A Wilmarth; Larry L David; Graeme Wistow
Journal:  FEBS J       Date:  2016-03-11       Impact factor: 5.542

Review 5.  Regulation of mTORC1 by PI3K signaling.

Authors:  Christian C Dibble; Lewis C Cantley
Journal:  Trends Cell Biol       Date:  2015-07-06       Impact factor: 20.808

6.  The TOR Pathway Plays Pleiotropic Roles in Growth and Stress Responses of the Fungal Pathogen Cryptococcus neoformans.

Authors:  Yee-Seul So; Dong-Gi Lee; Alexander Idnurm; Giuseppe Ianiri; Yong-Sun Bahn
Journal:  Genetics       Date:  2019-06-07       Impact factor: 4.562

Review 7.  Control of cell growth: Rag GTPases in activation of TORC1.

Authors:  Huirong Yang; Rui Gong; Yanhui Xu
Journal:  Cell Mol Life Sci       Date:  2012-12-16       Impact factor: 9.261

Review 8.  The Rac1 hypervariable region in targeting and signaling: a tail of many stories.

Authors:  B Daniel Lam; Peter L Hordijk
Journal:  Small GTPases       Date:  2013-01-25

Review 9.  Role of amino acid transporters in amino acid sensing.

Authors:  Peter M Taylor
Journal:  Am J Clin Nutr       Date:  2013-11-27       Impact factor: 7.045

Review 10.  Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR).

Authors:  David A Foster; Darin Salloum; Deepak Menon; Maria A Frias
Journal:  J Biol Chem       Date:  2014-07-02       Impact factor: 5.157
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.