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Literature DB >> 21962512

A DNA repair complex functions as an Oct4/Sox2 coactivator in embryonic stem cells.

Yick W Fong¹, Carla Inouye, Teppei Yamaguchi, Claudia Cattoglio, Ivan Grubisic, Robert Tjian.

Abstract

The transcriptional activators Oct4, Sox2, and Nanog cooperate with a wide array of cofactors to orchestrate an embryonic stem (ES) cell-specific gene expression program that forms the molecular basis of pluripotency. Here, we report using an unbiased in vitro transcription-biochemical complementation assay to discover a multisubunit stem cell coactivator complex (SCC) that is selectively required for the synergistic activation of the Nanog gene by Oct4 and Sox2. Purification, identification, and reconstitution of SCC revealed this coactivator to be the trimeric XPC-nucleotide excision repair complex. SCC interacts directly with Oct4 and Sox2 and is recruited to the Nanog and Oct4 promoters as well as a majority of genomic regions that are occupied by Oct4 and Sox2. Depletion of SCC/XPC compromised both pluripotency in ES cells and somatic cell reprogramming of fibroblasts to induced pluripotent stem (iPS) cells. This study identifies a transcriptional coactivator with diversified functions in maintaining ES cell pluripotency and safeguarding genome integrity.

Entities: CellLine Chemical Disease Gene Mutation Species

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Year: 2011 PMID： 21962512 PMCID： PMC3216680 DOI： 10.1016/j.cell.2011.08.038

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

52 in total

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78 in total

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Authors: Tiago J Dantas; Owen M Daly; Ciaran G Morrison
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4. Nucleotide excision repair capacity increases during differentiation of human embryonic carcinoma cells into neurons and muscle cells.

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