BACKGROUND: Opioid neurotransmission mediates hedonic value of sweet tastants; their intake may be exaggerated by the consumption of exogenous opioids (e.g., opioid dependence). Sweet Taste Test (STT) is a validated quantitative instrument assessing taste perception and hedonic features of sugar (sucrose) using a randomized and double-blind administration at five different sucrose concentrations ranging from 0.05 to 0.83 M. METHODS: The STT and cue-induced craving procedure were administered to opioid-dependent patients (n = 15) before and 1 week after the injection of a long-acting depot naltrexone (XRNT) preparation. RESULTS: Analyses of covariance, employing sucrose concentration and its perceived taste as covariates, showed that XRNT therapy significantly reduced the self-reported hedonic and motivational characteristics of sucrose. Greater reductions in both these characteristics were associated with more diminution in the cue-induced opioid craving. CONCLUSIONS: Opioid antagonism in opioid-dependent subjects leads to a smaller sweet taste reward, which, in turn, may be proportional to decreased opioid craving. These pilot results support the heuristic value of the STT as a potential marker of the XRNT treatment response and call for further inquiry into potential clinical applications of the test.
RCT Entities:
BACKGROUND: Opioid neurotransmission mediates hedonic value of sweet tastants; their intake may be exaggerated by the consumption of exogenous opioids (e.g., opioid dependence). Sweet Taste Test (STT) is a validated quantitative instrument assessing taste perception and hedonic features of sugar (sucrose) using a randomized and double-blind administration at five different sucrose concentrations ranging from 0.05 to 0.83 M. METHODS: The STT and cue-induced craving procedure were administered to opioid-dependent patients (n = 15) before and 1 week after the injection of a long-acting depot naltrexone (XRNT) preparation. RESULTS: Analyses of covariance, employing sucrose concentration and its perceived taste as covariates, showed that XRNT therapy significantly reduced the self-reported hedonic and motivational characteristics of sucrose. Greater reductions in both these characteristics were associated with more diminution in the cue-induced opioid craving. CONCLUSIONS: Opioid antagonism in opioid-dependent subjects leads to a smaller sweet taste reward, which, in turn, may be proportional to decreased opioid craving. These pilot results support the heuristic value of the STT as a potential marker of the XRNT treatment response and call for further inquiry into potential clinical applications of the test.
Authors: David W Oslin; Wade Berrettini; Henry R Kranzler; Helen Pettinati; Joel Gelernter; Joseph R Volpicelli; Charles P O'Brien Journal: Neuropsychopharmacology Date: 2003-06-18 Impact factor: 7.853
Authors: Frederick M Hecht; Jennifer Daubenmier; Elissa S Epel; Ashley E Mason; Robert H Lustig; Rashida R Brown; Michael Acree; Peter Bacchetti; Patricia J Moran; Mary Dallman; Barbara Laraia; Nancy Adler Journal: Appetite Date: 2015-04-27 Impact factor: 3.868
Authors: Zhenhao Shi; An-Li Wang; Kanchana Jagannathan; Victoria P Fairchild; Charles P O'Brien; Anna Rose Childress; Daniel D Langleben Journal: J Psychiatry Neurosci Date: 2018-07 Impact factor: 6.186
Authors: Cassie M Chandler; Jaren Reeves-Darby; Sherman A Jones; J Abigail McDonald; Guanguan Li; Md T Rahman; James M Cook; Donna M Platt Journal: Psychopharmacology (Berl) Date: 2019-01-12 Impact factor: 4.530
Authors: An-Li Wang; Steven B Lowen; Igor Elman; Zhenhao Shi; Victoria P Fairchild; Alexander Bouril; Ruben C Gur; Daniel D Langleben Journal: J Subst Abuse Treat Date: 2017-10-18
Authors: An-Li Wang; Dan Romer; Igor Elman; Bruce I Turetsky; Ruben C Gur; Daniel D Langleben Journal: Addict Biol Date: 2013-12-15 Impact factor: 4.280
Authors: Zhenhao Shi; An-Li Wang; Kanchana Jagannathan; Victoria P Fairchild; Charles P O'Brien; Anna Rose Childress; Daniel D Langleben Journal: J Psychiatry Neurosci Date: 2018-02-23 Impact factor: 6.186
Authors: Ashley E Mason; Barbara Laraia; Jennifer Daubenmier; Frederick M Hecht; Robert H Lustig; Eli Puterman; Nancy Adler; Mary Dallman; Michaela Kiernan; Ashley N Gearhardt; Elissa S Epel Journal: Eat Behav Date: 2015-07-02