Literature DB >> 2195604

Two-event model for carcinogenesis: biological, mathematical, and statistical considerations.

S H Moolgavkar1, G Luebeck.   

Abstract

A two-mutation model for carcinogenesis is reviewed. General principles in fitting the model to epidemiologic and experimental data are discussed, and some examples are given. A general solution to the model with time-dependent parameters is developed, and its use is illustrated by application to data from an experiment in which rats exposed to radon developed lung tumors.

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Year:  1990        PMID： 2195604     DOI： 10.1111/j.1539-6924.1990.tb01053.x

Source DB:  PubMed          Journal:  Risk Anal        ISSN： 0272-4332            Impact factor:   4.000


  41 in total

1.  Radon-induced lung cancer in French and Czech miner cohorts described with a two-mutation cancer model.

Authors:  Marco J P Brugmans; Sietse M Rispens; Harmen Bijwaard; Dominique Laurier; Agnes Rogel; Ladislav Tomásek; Margot Tirmarche
Journal:  Radiat Environ Biophys       Date:  2004-08-17       Impact factor: 1.925

2.  Fitting the two-stage model of carcinogenesis to nested case-control data on the Colorado Plateau uranium miners: dependence on data assumptions.

Authors:  Richard G E Haylock; Colin R Muirhead
Journal:  Radiat Environ Biophys       Date:  2003-11-15       Impact factor: 1.925

3.  Breast cancer risk in atomic bomb survivors from multi-model inference with incidence data 1958-1998.

Authors:  J C Kaiser; P Jacob; R Meckbach; H M Cullings
Journal:  Radiat Environ Biophys       Date:  2011-09-23       Impact factor: 1.925

4.  Age-specific incidence of cancer: Phases, transitions, and biological implications.

Authors:  Rafael Meza; Jihyoun Jeon; Suresh H Moolgavkar; E Georg Luebeck
Journal:  Proc Natl Acad Sci U S A       Date:  2008-10-20       Impact factor: 11.205

Review 5.  Human adult stem cells as the target cells for the initiation of carcinogenesis and for the generation of "cancer stem cells".

Authors:  James E Trosko
Journal:  Int J Stem Cells       Date:  2008-11       Impact factor: 2.500

6.  Modeling of cell inactivation and carcinogenesis in the atomic bomb survivors with applications to the mortality from all solid, stomach and liver cancer.

Authors:  Peter Jacob; Linda Walsh; Markus Eidemüller
Journal:  Radiat Environ Biophys       Date:  2008-05-15       Impact factor: 1.925

7.  Evaluation of screening strategies for pre-malignant lesions using a biomathematical approach.

Authors:  Jihyoun Jeon; Rafael Meza; Suresh H Moolgavkar; E Georg Luebeck
Journal:  Math Biosci       Date:  2008-02-26       Impact factor: 2.144

8.  On the parameters of the clonal expansion model.

Authors:  W F Heidenreich
Journal:  Radiat Environ Biophys       Date:  1996-05       Impact factor: 1.925

9.  Uncertainties in biologically-based modeling of formaldehyde-induced respiratory cancer risk: identification of key issues.

Authors:  Ravi P Subramaniam; Chao Chen; Kenny S Crump; Danielle Devoney; John F Fox; Christopher J Portier; Paul M Schlosser; Chad M Thompson; Paul White
Journal:  Risk Anal       Date:  2008-06-28       Impact factor: 4.000

10.  Parallel routes of human carcinoma development: implications of the age-specific incidence data.

Authors:  James P Brody
Journal:  PLoS One       Date:  2009-09-23       Impact factor: 3.240
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