Antonio Terracciano1, Angelina R Sutin2, Yang An3, Richard J O'Brien4, Luigi Ferrucci3, Alan B Zonderman3, Susan M Resnick3. 1. National Institute on Aging, National Institutes of Health, Baltimore, MD, USA; Florida State University College of Medicine, Tallahassee, FL, USA. Electronic address: antonio.terracciano@med.fsu.edu. 2. National Institute on Aging, National Institutes of Health, Baltimore, MD, USA; Florida State University College of Medicine, Tallahassee, FL, USA. 3. National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. 4. Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Abstract
BACKGROUND: We examine whether broad factors and specific facets of personality are associated with increased risk of incident Alzheimer's disease (AD) in a long-run longitudinal study and a meta-analysis of published studies. METHODS: Participants (n = 1671) were monitored for up to 22 years from a baseline personality assessment. The meta-analysis pooled results from up to five prospective studies (n = 5054). RESULTS: Individuals with scores in the top quartile of neuroticism (hazard ratio = 3.1; 95% confidence interval = 1.6-6.0) or the lowest quartile of conscientiousness (hazard ratio = 3.3; 95% confidence interval = 1.4-7.4) had a threefold increased risk of incident AD. Among the components of these traits, self-discipline and depression had the strongest associations with incident AD. The meta-analysis confirmed the associations of neuroticism (P = 2 × 10(-9)) and conscientiousness (P = 2 × 10(-6)), along with weaker effects for openness and agreeableness (P < .05). CONCLUSIONS: The current study and meta-analysis indicate that personality traits are associated with increased risk of AD, with effect sizes similar to those of well-established clinical and lifestyle risk factors.
BACKGROUND: We examine whether broad factors and specific facets of personality are associated with increased risk of incident Alzheimer's disease (AD) in a long-run longitudinal study and a meta-analysis of published studies. METHODS:Participants (n = 1671) were monitored for up to 22 years from a baseline personality assessment. The meta-analysis pooled results from up to five prospective studies (n = 5054). RESULTS: Individuals with scores in the top quartile of neuroticism (hazard ratio = 3.1; 95% confidence interval = 1.6-6.0) or the lowest quartile of conscientiousness (hazard ratio = 3.3; 95% confidence interval = 1.4-7.4) had a threefold increased risk of incident AD. Among the components of these traits, self-discipline and depression had the strongest associations with incident AD. The meta-analysis confirmed the associations of neuroticism (P = 2 × 10(-9)) and conscientiousness (P = 2 × 10(-6)), along with weaker effects for openness and agreeableness (P < .05). CONCLUSIONS: The current study and meta-analysis indicate that personality traits are associated with increased risk of AD, with effect sizes similar to those of well-established clinical and lifestyle risk factors.
Authors: Constantine G Lyketsos; Maria C Carrillo; J Michael Ryan; Ara S Khachaturian; Paula Trzepacz; Joan Amatniek; Jesse Cedarbaum; Robert Brashear; David S Miller Journal: Alzheimers Dement Date: 2011-09 Impact factor: 21.566
Authors: Angelina R Sutin; Antonio Terracciano; Melissa H Kitner-Triolo; Manuela Uda; David Schlessinger; Alan B Zonderman Journal: Psychol Aging Date: 2011-06-27
Authors: R S Wilson; L L Barnes; D A Bennett; Y Li; J L Bienias; C F Mendes de Leon; D A Evans Journal: Neurology Date: 2005-01-25 Impact factor: 9.910
Authors: Antonio Terracciano; Diego Iacono; Richard J O'Brien; Juan C Troncoso; Yang An; Angelina R Sutin; Luigi Ferrucci; Alan B Zonderman; Susan M Resnick Journal: Neurobiol Aging Date: 2012-10-02 Impact factor: 4.673
Authors: John Gallacher; Anthony Bayer; Mark Fish; Janet Pickering; Sofia Pedro; Frank Dunstan; Shah Ebrahim; Yoav Ben-Shlomo Journal: Psychosom Med Date: 2009-06-24 Impact factor: 4.312
Authors: Angelina R Sutin; Yannick Stephan; Martina Luchetti; Antonio Terracciano Journal: Int J Geriatr Psychiatry Date: 2017-09-04 Impact factor: 3.485