OBJECTIVES: To evaluate the association between collateral formation and some environmental factors along with a polymorphism in HIF-1A gene in selected Iranian patients with CAD. DESIGN AND METHODS: Patients with ≥ 70% narrowing in at least one coronary vessel according to coronary angiography were enrolled. The patients' demographic, clinical and biochemical data were collected. The presence of C1772T polymorphisms within HIF-1A was analyzed using the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). RESULTS: There is no significant difference between the patients with and without collaterals according to the frequency of T allele or HIF-1A variants. The higher severity of coronary vessel obstruction was positive predictor of collateral formation (OR=1.026, 95%, CI: 1.02-0.04, p<0.001), whereas aging and cigarette smoking were negative predictors (OR=0.95, 95% CI: 0.91-0.99, p<0.05; OR=0.30, 95% CI: 0.11-0.79, p <0.05; respectively). CONCLUSIONS: The findings indicate not any significant association between collateral formation and polymorphic variants of HIF-1A and P582S substitution does not appear to influence the collateral formation in patients with myocardial ischemia.
OBJECTIVES: To evaluate the association between collateral formation and some environmental factors along with a polymorphism in HIF-1A gene in selected Iranian patients with CAD. DESIGN AND METHODS: Patients with ≥ 70% narrowing in at least one coronary vessel according to coronary angiography were enrolled. The patients' demographic, clinical and biochemical data were collected. The presence of C1772T polymorphisms within HIF-1A was analyzed using the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). RESULTS: There is no significant difference between the patients with and without collaterals according to the frequency of T allele or HIF-1A variants. The higher severity of coronary vessel obstruction was positive predictor of collateral formation (OR=1.026, 95%, CI: 1.02-0.04, p<0.001), whereas aging and cigarette smoking were negative predictors (OR=0.95, 95% CI: 0.91-0.99, p<0.05; OR=0.30, 95% CI: 0.11-0.79, p <0.05; respectively). CONCLUSIONS: The findings indicate not any significant association between collateral formation and polymorphic variants of HIF-1A and P582S substitution does not appear to influence the collateral formation in patients with myocardial ischemia.
Authors: Joan Duran; Pilar Sánchez Olavarría; Marina Mola; Víctor Götzens; Julio Carballo; Eva Martín Pelegrina; Màrius Petit; Omar Abdul-Jawad; Imanol Otaegui; Bruno García del Blanco; David García-Dorado; Josep Reig; Alex Cordero; Josep Maria de Anta Journal: BMC Cardiovasc Disord Date: 2015-05-12 Impact factor: 2.298
Authors: Amit Lalwani; Joanna Warren; David Liuwantara; Wayne J Hawthorne; Philip J O'Connell; Frank J Gonzalez; Rebecca A Stokes; Jennifer Chen; D Ross Laybutt; Maria E Craig; Michael M Swarbrick; Cecile King; Jenny E Gunton Journal: Cell Rep Date: 2019-05-21 Impact factor: 9.423
Authors: Vincent Amoah; Benjamin Wrigley; Eric Holroyd; Andrew Smallwood; Angel L Armesilla; Alan Nevill; James Cotton Journal: SAGE Open Med Date: 2016-06-24