OBJECTIVE: The production of neurotoxic β-amyloid and the formation of hyperphosphorylated tau are thought to be critical steps contributing to the neuropathological mechanisms in Alzheimer's disease (AD). However, there remains an argument as to their importance in the onset of AD. Recent studies have shown that axonopathy is considered as an early stage of AD. However, the exact relationship between axonopathy and the origin and development of classic neuropathological changes such as senile plaques (SPs) and neurofibrillary tangles (NFTs) is unclear. The present study aimed to investigate this relationship. METHODS: Postmortem tracing, combined with the immunohistochemical or immunofluorescence staining, was used to detect axonopathy and the formation of SPs and NFTs. RESULTS: Axonal leakage-a novel type of axonopathy, was usually accompanied with the extensive swollen axons and varicosities, and was associated with the origin and development of Aβ plaques and hyperphosphorylated tau in the brains of AD patients. CONCLUSION: Axonopathy, particularly axonal leakage, might be a key event in the initiation of the neuropathological processes in AD.
OBJECTIVE: The production of neurotoxic β-amyloid and the formation of hyperphosphorylated tau are thought to be critical steps contributing to the neuropathological mechanisms in Alzheimer's disease (AD). However, there remains an argument as to their importance in the onset of AD. Recent studies have shown that axonopathy is considered as an early stage of AD. However, the exact relationship between axonopathy and the origin and development of classic neuropathological changes such as senile plaques (SPs) and neurofibrillary tangles (NFTs) is unclear. The present study aimed to investigate this relationship. METHODS: Postmortem tracing, combined with the immunohistochemical or immunofluorescence staining, was used to detect axonopathy and the formation of SPs and NFTs. RESULTS: Axonal leakage-a novel type of axonopathy, was usually accompanied with the extensive swollen axons and varicosities, and was associated with the origin and development of Aβ plaques and hyperphosphorylated tau in the brains of ADpatients. CONCLUSION:Axonopathy, particularly axonal leakage, might be a key event in the initiation of the neuropathological processes in AD.
Authors: James C Vickers; Anna E King; Adele Woodhouse; Matthew T Kirkcaldie; Jerome A Staal; Graeme H McCormack; Catherine A Blizzard; Ruth E J Musgrove; Stanislaw Mitew; Yao Liu; Jyoti A Chuckowree; Olivier Bibari; Tracey C Dickson Journal: Brain Res Bull Date: 2009-08-13 Impact factor: 4.077
Authors: B Steiner; E M Mandelkow; J Biernat; N Gustke; H E Meyer; B Schmidt; G Mieskes; H D Söling; D Drechsel; M W Kirschner; M Goedert; E Mandelkow Journal: EMBO J Date: 1990-11 Impact factor: 11.598
Authors: Camila Vieira Ligo Teixeira; Thiago J R Rezende; Marina Weiler; Mateus H Nogueira; Brunno M Campos; Luiz F L Pegoraro; Jessica E Vicentini; Gabriela Scriptore; Fernando Cendes; Marcio L F Balthazar Journal: Age (Dordr) Date: 2016-04-23
Authors: Qinan Zhang; Teng Gao; Yi Luo; Xijuan Chen; Ge Gao; Xiaoqun Gao; Yiwu Zhou; Jiapei Dai Journal: PLoS One Date: 2012-03-23 Impact factor: 3.240
Authors: Selene Lomoio; Rachel Willen; WonHee Kim; Kevin Z Ho; Edward K Robinson; Dmitry Prokopenko; Matthew E Kennedy; Rudolph E Tanzi; Giuseppina Tesco Journal: Sci Transl Med Date: 2020-11-18 Impact factor: 17.956