Literature DB >> 21902001

Recognition, diagnosis and treatment of fetal alcohol syndrome.

G Bradley Schaefer1, David Deere.   

Abstract

Fetal Alcohol spectrum disorders are extremely common. The clinical impact and societal effects are tremendous. Prevention and treatment of these disorders begins with an accurate diagnosis. All health care providers who work with children (and adults) with special health care needs should be alert to these findings. The key to early diagnosis is to always keep the diagnostic possibility in the broad differential diagnoses of growth and developmental disorders. As with most conditions, early recognition and intervention is associated with better outcomes. Once an FASD is identified in a specific patient, prompt referrals and enrollment in indicated services are necessary to get the best outcomes. In this article we review the diagnostic criteria and clues to prompt early identification of FASDs. We also discuss the therapeutic options shown to be most effective for this group of individuals.

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Year:  2011        PMID: 21902001

Source DB:  PubMed          Journal:  J Ark Med Soc        ISSN: 0004-1858


  7 in total

1.  DNA methylation-independent growth restriction and altered developmental programming in a mouse model of preconception male alcohol exposure.

Authors:  Richard C Chang; William M Skiles; Sarah S Chronister; Haiqing Wang; Gabrielle I Sutton; Yudhishtar S Bedi; Matthew Snyder; Charles R Long; Michael C Golding
Journal:  Epigenetics       Date:  2017-12-07       Impact factor: 4.528

2.  Neonatal ethanol exposure results in dose-dependent impairments in the acquisition and timing of the conditioned eyeblink response and altered cerebellar interpositus nucleus and hippocampal CA1 unit activity in adult rats.

Authors:  Derick H Lindquist; Greta Sokoloff; Eric Milner; Joseph E Steinmetz
Journal:  Alcohol       Date:  2013-07-19       Impact factor: 2.405

3.  Commonality in Down and fetal alcohol syndromes.

Authors:  Jeffrey P Solzak; Yun Liang; Feng C Zhou; Randall J Roper
Journal:  Birth Defects Res A Clin Mol Teratol       Date:  2013-04-03

4.  Preconception paternal alcohol exposure exerts sex-specific effects on offspring growth and long-term metabolic programming.

Authors:  Richard C Chang; Haiqing Wang; Yudhishtar Bedi; Michael C Golding
Journal:  Epigenetics Chromatin       Date:  2019-01-22       Impact factor: 4.954

5.  Maternal background alters the penetrance of growth phenotypes and sex-specific placental adaptation of offspring sired by alcohol-exposed males.

Authors:  Kara N Thomas; Katherine N Zimmel; Alexis N Roach; Alison Basel; Nicole A Mehta; Yudhishtar S Bedi; Michael C Golding
Journal:  FASEB J       Date:  2021-12       Impact factor: 5.834

6.  Paternal alcohol exposures program intergenerational hormetic effects on offspring fetoplacental growth.

Authors:  Kara N Thomas; Katherine N Zimmel; Alison Basel; Alexis N Roach; Nicole A Mehta; Kelly R Thomas; Luke J Dotson; Yudhishtar S Bedi; Michael C Golding
Journal:  Front Cell Dev Biol       Date:  2022-08-11

7.  Programmed suppression of oxidative phosphorylation and mitochondrial function by gestational alcohol exposure correlate with widespread increases in H3K9me2 that do not suppress transcription.

Authors:  Richard C Chang; Kara N Thomas; Nicole A Mehta; Kylee J Veazey; Scott E Parnell; Michael C Golding
Journal:  Epigenetics Chromatin       Date:  2021-06-15       Impact factor: 4.954

  7 in total

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