Paul D Blanc1. 1. Department of Medicine, Division of Occupational and Environmental Medicine, University of California, San Francisco, San Francisco, CA 94117, USA. paul.blanc@ucsf.edu
Abstract
BACKGROUND AND AIMS: This review summarizes the scientific literature relevant to occupational risk factors for chronic obstructive pulmonary disease (COPD). MATERIAL AND METHODS: This review emphasizes recent work in the field, while placing this in the context of two previous systematic reviews of the subject. RESULTS: Both the earlier summaries of the literature estimated that the population attributable risk percent (PAR%) of COPD linked to occupational exposures is approximately 15%. More recent studies also strongly support the association between workplace exposures and COPD. Among never smokers, the PAR% for work-related factors may approach 40%. Emerging data also indicate that occupational exposures, at a minimum, are additive to smoking-associated risk of COPD. CONCLUSIONS: The PAR% for work-related COPD is at least 15%. Scientific significance. The consistency, strength, and plausibility of these data support a causal relationship between occupational exposures and COPD.
BACKGROUND AND AIMS: This review summarizes the scientific literature relevant to occupational risk factors for chronic obstructive pulmonary disease (COPD). MATERIAL AND METHODS: This review emphasizes recent work in the field, while placing this in the context of two previous systematic reviews of the subject. RESULTS: Both the earlier summaries of the literature estimated that the population attributable risk percent (PAR%) of COPD linked to occupational exposures is approximately 15%. More recent studies also strongly support the association between workplace exposures and COPD. Among never smokers, the PAR% for work-related factors may approach 40%. Emerging data also indicate that occupational exposures, at a minimum, are additive to smoking-associated risk of COPD. CONCLUSIONS: The PAR% for work-related COPD is at least 15%. Scientific significance. The consistency, strength, and plausibility of these data support a causal relationship between occupational exposures and COPD.
Authors: Susan M Tarlo; Jean-Luc Malo; Frédéric de Blay; Nicole Le Moual; Paul Henneberger; Dick Heederik; Monika Raulf; Christopher Carlsten; André Cartier Journal: Ann Am Thorac Soc Date: 2017-09
Authors: Ellen Fischer Mølgaard; Harald Hannerz; Finn Tüchsen; Charlotte Brauer; Lilli Kirkeskov Journal: BMJ Open Date: 2013-01-11 Impact factor: 2.692