Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Processing of DNA structures via DNA unwinding and branch migration by the S. cerevisiae Mph1 protein.

Literature DB >> 21880555

Processing of DNA structures via DNA unwinding and branch migration by the S. cerevisiae Mph1 protein.

Xiao-Feng Zheng¹, Rohit Prakash, Dorina Saro, Simonne Longerich, Hengyao Niu, Patrick Sung.

Abstract

The budding yeast Mph1 protein, the putative ortholog of human FANCM, possesses a 3' to 5' DNA helicase activity and is capable of disrupting the D-loop structure to suppress chromosome arm crossovers in mitotic homologous recombination. Similar to FANCM, genetic studies have implicated Mph1 in DNA replication fork repair. Consistent with this genetic finding, we show here that Mph1 is able to mediate replication fork reversal, and to process the Holliday junction via DNA branch migration. Moreover, Mph1 unwinds 3' and 5' DNA Flap structures that bear key features of the D-loop. These biochemical results not only provide validation for a role of Mph1 in the repair of damaged replication forks, but they also offer mechanistic insights as to its ability to efficiently disrupt the D-loop intermediate.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2011 PMID： 21880555 PMCID： PMC3185188 DOI： 10.1016/j.dnarep.2011.08.002

Source DB: PubMed Journal: DNA Repair (Amst) ISSN： 1568-7856

26 in total

1. The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.

Authors: Xavier Veaute; Josette Jeusset; Christine Soustelle; Stephen C Kowalczykowski; Eric Le Cam; Francis Fabre
Journal: Nature Date: 2003-05-15 Impact factor: 49.962

Review 2. The FANCM family of DNA helicases/translocases.

Authors: Matthew C Whitby
Journal: DNA Repair (Amst) Date: 2010-02-08

3. A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.

Authors: Zhijiang Yan; Mathieu Delannoy; Chen Ling; Danielle Daee; Fekret Osman; Parameswary A Muniandy; Xi Shen; Anneke B Oostra; Hansen Du; Jurgen Steltenpool; Ti Lin; Beatrice Schuster; Chantal Décaillet; Andrzej Stasiak; Alicja Z Stasiak; Stacie Stone; Maureen E Hoatlin; Detlev Schindler; Christopher L Woodcock; Hans Joenje; Ranjan Sen; Johan P de Winter; Lei Li; Michael M Seidman; Matthew C Whitby; Kyungjae Myung; Angelos Constantinou; Weidong Wang
Journal: Mol Cell Date: 2010-03-26 Impact factor: 17.970

4. The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response.

Authors: Min Huang; Jung Min Kim; Bunsyo Shiotani; Kailin Yang; Lee Zou; Alan D D'Andrea
Journal: Mol Cell Date: 2010-07-30 Impact factor: 17.970

5. Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.

Authors: Hengyao Niu; Woo-Hyun Chung; Zhu Zhu; Youngho Kwon; Weixing Zhao; Peter Chi; Rohit Prakash; Changhyun Seong; Dongqing Liu; Lucy Lu; Grzegorz Ira; Patrick Sung
Journal: Nature Date: 2010-09-02 Impact factor: 49.962

6. MPH1, a yeast gene encoding a DEAH protein, plays a role in protection of the genome from spontaneous and chemically induced damage.

Authors: J Scheller; A Schürer; C Rudolph; S Hettwer; W Kramer
Journal: Genetics Date: 2000-07 Impact factor: 4.562

7. Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1-Top3.

Authors: Petr Cejka; Jody L Plank; Csanad Z Bachrati; Ian D Hickson; Stephen C Kowalczykowski
Journal: Nat Struct Mol Biol Date: 2010-10-10 Impact factor: 15.369

8. DNA helicase Srs2 disrupts the Rad51 presynaptic filament.

Authors: Lumir Krejci; Stephen Van Komen; Ying Li; Jana Villemain; Mothe Sreedhar Reddy; Hannah Klein; Thomas Ellenberger; Patrick Sung
Journal: Nature Date: 2003-05-15 Impact factor: 49.962

9. Yeast MPH1 gene functions in an error-free DNA damage bypass pathway that requires genes from Homologous recombination, but not from postreplicative repair.

Authors: K Anke Schürer; Christian Rudolph; Helle D Ulrich; Wilfried Kramer
Journal: Genetics Date: 2004-04 Impact factor: 4.562

Review 10. The DNA damage response: making it safe to play with knives.

Authors: Alberto Ciccia; Stephen J Elledge
Journal: Mol Cell Date: 2010-10-22 Impact factor: 17.970

43 in total

1. Rad5 dysregulation drives hyperactive recombination at replication forks resulting in cisplatin sensitivity and genome instability.

Authors: Eric E Bryant; Ivana Šunjevarić; Luke Berchowitz; Rodney Rothstein; Robert J D Reid
Journal: Nucleic Acids Res Date: 2019-09-26 Impact factor: 16.971

Processing of DNA structures via DNA unwinding and branch migration by the S. cerevisiae Mph1 protein.

1. The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.

Review 2. The FANCM family of DNA helicases/translocases.

3. A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.

4. The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response.

5. Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.

6. MPH1, a yeast gene encoding a DEAH protein, plays a role in protection of the genome from spontaneous and chemically induced damage.

7. Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1-Top3.

8. DNA helicase Srs2 disrupts the Rad51 presynaptic filament.

9. Yeast MPH1 gene functions in an error-free DNA damage bypass pathway that requires genes from Homologous recombination, but not from postreplicative repair.

Review 10. The DNA damage response: making it safe to play with knives.

1. Rad5 dysregulation drives hyperactive recombination at replication forks resulting in cisplatin sensitivity and genome instability.

Review 2. Replication fork regression and its regulation.

3. Roles of DNA helicases in the mediation and regulation of homologous recombination.

4. MTE1 Functions with MPH1 in Double-Strand Break Repair.

5. Dynamic Processing of Displacement Loops during Recombinational DNA Repair.

6. Restriction of replication fork regression activities by a conserved SMC complex.

Review 7. Helicase Mechanisms During Homologous Recombination in Saccharomyces cerevisiae.

Review 8. Multiple cellular mechanisms prevent chromosomal rearrangements involving repetitive DNA.

9. Biochemical Activities and Genetic Functions of the Drosophila melanogaster Fancm Helicase in DNA Repair.

Review 10. An Overview of the Molecular Mechanisms of Recombinational DNA Repair.