Literature DB >> 21880494

Cleavable linkers in chemical biology.

Geoffray Leriche1, Louise Chisholm, Alain Wagner.   

Abstract

Interest in cleavable linkers is growing due to the rapid development and expansion of chemical biology. The chemical constrains imposed by the biological conditions cause significant challenges for organic chemists. In this review we will present an overview of the cleavable linkers used in chemical biology classified according to their cleavage conditions by enzymes, nucleophilic/basic reagents, reducing agents, photo-irradiation, electrophilic/acidic reagents, organometallic and metal reagents, oxidizing reagents.
Copyright © 2011. Published by Elsevier Ltd.

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Year:  2011        PMID： 21880494     DOI： 10.1016/j.bmc.2011.07.048

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  35 in total

1.  A Simple and Efficient Synthesis of an Acid-labile Polyphosphoramidate by Organobase-catalyzed Ring-Opening Polymerization and Transformation to Polyphosphoester Ionomers by Acid Treatment.

Authors:  Shiyi Zhang; Hai Wang; Yuefei Shen; Fuwu Zhang; Kellie Seetho; Jiong Zou; John-Stephen A Taylor; Andrew P Dove; Karen L Wooley
Journal:  Macromolecules       Date:  2013-07-09       Impact factor: 5.985

2.  Genetic encoding of 2-aryl-5-carboxytetrazole-based protein photo-cross-linkers.

Authors:  Yulin Tian; Qing Lin
Journal:  Chem Commun (Camb)       Date:  2018-04-26       Impact factor: 6.222

3.  Substituent Effects on the pH Sensitivity of Acetals and Ketals and Their Correlation with Encapsulation Stability in Polymeric Nanogels.

Authors:  Bin Liu; S Thayumanavan
Journal:  J Am Chem Soc       Date:  2017-02-02       Impact factor: 15.419

4.  Increased brain uptake of targeted nanoparticles by adding an acid-cleavable linkage between transferrin and the nanoparticle core.

Authors:  Andrew J Clark; Mark E Davis
Journal:  Proc Natl Acad Sci U S A       Date:  2015-09-21       Impact factor: 11.205

5.  A simple and effective cleavable linker for chemical proteomics applications.

Authors:  Yinliang Yang; Hannes Hahne; Bernhard Kuster; Steven H L Verhelst
Journal:  Mol Cell Proteomics       Date:  2012-10-01       Impact factor: 5.911

6.  Simple and Efficient Room-Temperature Release of Biotinylated Nucleic Acids from Streptavidin and Its Application to Selective Molecular Detection.

Authors:  Samuel Bearden; Fanny Wang; Adam R Hall
Journal:  Anal Chem       Date:  2019-06-12       Impact factor: 6.986

7.  Cyclic acetals as cleavable linkers for affinity capture.

Authors:  Siyeon Lee; Wei Wang; Younjoo Lee; Nicole S Sampson
Journal:  Org Biomol Chem       Date:  2015-08-21       Impact factor: 3.876

8.  New Dioxaborolane Chemistry Enables [(18)F]-Positron-Emitting, Fluorescent [(18)F]-Multimodality Biomolecule Generation from the Solid Phase.

Authors:  Erik A Rodriguez; Ye Wang; Jessica L Crisp; David R Vera; Roger Y Tsien; Richard Ting
Journal:  Bioconjug Chem       Date:  2016-04-27       Impact factor: 4.774

9.  Bioorthogonal approach to identify unsuspected drug targets in live cells.

Authors:  Katherine S Yang; Ghyslain Budin; Carlos Tassa; Olivier Kister; Ralph Weissleder
Journal:  Angew Chem Int Ed Engl       Date:  2013-08-19       Impact factor: 15.336

Review 10.  State-of-the-art in design rules for drug delivery platforms: lessons learned from FDA-approved nanomedicines.

Authors:  Charlene M Dawidczyk; Chloe Kim; Jea Ho Park; Luisa M Russell; Kwan Hyi Lee; Martin G Pomper; Peter C Searson
Journal:  J Control Release       Date:  2014-05-27       Impact factor: 9.776
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