Literature DB >> 21879331

Apoptosis of HL-60 leukemia cells induced by carbazole alkaloids isolated from Murraya euchrestifolia.

Chihiro Ito1, Masataka Itoigawa, Keisuke Nakao, Tomiyasu Murata, Norio Kaneda, Hiroshi Furukawa.   

Abstract

We carried out primary screening of 13 carbazole alkaloids isolated from the plant species Murraya euchrestifolia (Rutaceae) on cell growth inhibition of the human leukemia cell line HL-60. Among them, murrayafoline-A (1) and murrayazolinine (7) exhibited significant growth suppression due to apoptosis mediated by the activation of the caspase-9/caspase-3 pathway.

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Year:  2011        PMID： 21879331     DOI： 10.1007/s11418-011-0584-0

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  9 in total

1.  New carbazole alkaloids from Clausena anisata with antitumor promoting activity.

Authors:  C Ito; S Katsuno; M Itoigawa; N Ruangrungsi; T Mukainaka; M Okuda; Y Kitagawa; H Tokuda; H Nishino; H Furukawa
Journal:  J Nat Prod       Date:  2000-01       Impact factor: 4.050

Review 2.  The expanding role of mitochondria in apoptosis.

Authors:  X Wang
Journal:  Genes Dev       Date:  2001-11-15       Impact factor: 11.361

3.  Induction of apoptosis by carbazole alkaloids isolated from Murraya koenigii.

Authors:  C Ito; M Itoigawa; K Nakao; T Murata; M Tsuboi; N Kaneda; H Furukawa
Journal:  Phytomedicine       Date:  2005-09-15       Impact factor: 5.340

4.  Antioxidative activity of carbazoles from Murraya koenigii leaves.

Authors:  Y Tachibana; H Kikuzaki; N H Lajis; N Nakatani
Journal:  J Agric Food Chem       Date:  2001-11       Impact factor: 5.279

Review 5.  The role of proteases during apoptosis.

Authors:  T Patel; G J Gores; S H Kaufmann
Journal:  FASEB J       Date:  1996-04       Impact factor: 5.191

6.  Biologically active carbazole alkaloids from Murraya koenigii.

Authors:  R S Ramsewak; M G Nair; G M Strasburg; D L DeWitt; J L Nitiss
Journal:  J Agric Food Chem       Date:  1999-02       Impact factor: 5.279

7.  Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents.

Authors:  M Itoigawa; Y Kashiwada; C Ito; H Furukawa; Y Tachibana; K F Bastow; K H Lee
Journal:  J Nat Prod       Date:  2000-07       Impact factor: 4.050

8.  Antimutagenicity of some edible Thai plants, and a bioactive carbazole alkaloid, mahanine, isolated from Micromelum minutum.

Authors:  Kazuhiko Nakahara; Gassinee Trakoontivakorn; Najeeb S Alzoreky; Hiroshi Ono; Mayumi Onishi-Kameyama; Mitsuru Yoshida
Journal:  J Agric Food Chem       Date:  2002-08-14       Impact factor: 5.279

9.  Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.

Authors:  Chihiro Ito; Masataka Itoigawa; Atsuko Sato; Choudhury M Hasan; Mohammad A Rashid; Harukuni Tokuda; Teruo Mukainaka; Hoyoku Nishino; Hiroshi Furukawa
Journal:  J Nat Prod       Date:  2004-09       Impact factor: 4.050
  9 in total
  2 in total

1.  Functional, electrophysiological and molecular docking analysis of the modulation of Cav 1.2 channels in rat vascular myocytes by murrayafoline A.

Authors:  S Saponara; M Durante; O Spiga; P Mugnai; G Sgaragli; T T Huong; P N Khanh; N T Son; N M Cuong; F Fusi
Journal:  Br J Pharmacol       Date:  2015-12-23       Impact factor: 8.739

Review 2.  Phyto-Carbazole Alkaloids from the Rutaceae Family as Potential Protective Agents against Neurodegenerative Diseases.

Authors:  Mario A Tan; Niti Sharma; Seong Soo A An
Journal:  Antioxidants (Basel)       Date:  2022-03-01
  2 in total

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