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Literature DB >> 10563914

Biologically active carbazole alkaloids from Murraya koenigii.

R S Ramsewak¹, M G Nair, G M Strasburg, D L DeWitt, J L Nitiss.

Abstract

The bioassay guided fractionation of the acetone extract of the fresh leaves of Murraya koenigii resulted in the isolation of three bioactive carbazole alkaloids, mahanimbine (1), murrayanol (2), and mahanine (3), as confirmed from their (1)H and (13)C NMR spectral data. Compound 2 showed an IC(50) of 109 microg/mL against hPGHS-1 and an IC(50) of 218 microg/mL against hPGHS-2 in antiinflammatory assays, while compound 1 displayed antioxidant activity at 33.1 microg/mL. All three compounds were mosquitocidal and antimicrobial and exhibited topoisomerase I and II inhibition activities.

Entities: Chemical Gene Species

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Year: 1999 PMID： 10563914 DOI： 10.1021/jf9805808

Source DB: PubMed Journal: J Agric Food Chem ISSN： 0021-8561 Impact factor: 5.279

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Cited

50 in total

1. Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo.

Authors: Sayantani Sarkar; Devawati Dutta; Suman Kumar Samanta; Kaushik Bhattacharya; Bikas Chandra Pal; Jinping Li; Kaustubh Datta; Chhabinath Mandal; Chitra Mandal
Journal: Int J Cancer Date: 2012-07-09 Impact factor: 7.396

2. Genetic relationships among wild and cultivated accessions of curry leaf plant (Murraya koenigii (L.) Spreng.), as revealed by DNA fingerprinting methods.

Authors: Sushma Verma; T S Rana
Journal: Mol Biotechnol Date: 2013-02 Impact factor: 2.695

3. Mahanine, a carbazole alkaloid from Micromelum minutum, inhibits cell growth and induces apoptosis in U937 cells through a mitochondrial dependent pathway.

Authors: Molay Kumar Roy; Vipaporn Na Thalang; Gassinee Trakoontivakorn; Kazuhiko Nakahara
Journal: Br J Pharmacol Date: 2005-05 Impact factor: 8.739

Biologically active carbazole alkaloids from Murraya koenigii.

1. Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo.

2. Genetic relationships among wild and cultivated accessions of curry leaf plant (Murraya koenigii (L.) Spreng.), as revealed by DNA fingerprinting methods.

3. Mahanine, a carbazole alkaloid from Micromelum minutum, inhibits cell growth and induces apoptosis in U937 cells through a mitochondrial dependent pathway.

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