BACKGROUND: The household secondary attack proportion (SAP) is commonly used to measure the transmissibility of an infectious disease. METHODS: We analyzed the final outbreak size distributions of pandemic A(H1N1), seasonal A(H1N1), and A(H3N2) infections identified in paired sera collected from members of 117 Hong Kong households in April and in August-October 2009. RESULTS: The estimated community probability of infection overall was higher for children than adults; the probability was similar for pandemic A(H1N1) and seasonal A(H3N2) influenza. The household SAP for pandemic A(H1N1) was higher in children than in adults, whereas for seasonal A(H3N2), it was similar in children and adults. The estimated SAPs were similar for seasonal A(H3N2) and pandemic A(H1N1) after excluding persons with higher baseline antibody titers from analysis. CONCLUSIONS: Pandemic and seasonal influenza A viruses had similar age-specific transmissibility in a cohort of initially uninfected households, after adjustment for baseline immunity.
BACKGROUND: The household secondary attack proportion (SAP) is commonly used to measure the transmissibility of an infectious disease. METHODS: We analyzed the final outbreak size distributions of pandemic A(H1N1), seasonal A(H1N1), and A(H3N2) infections identified in paired sera collected from members of 117 Hong Kong households in April and in August-October 2009. RESULTS: The estimated community probability of infection overall was higher for children than adults; the probability was similar for pandemic A(H1N1) and seasonal A(H3N2) influenza. The household SAP for pandemic A(H1N1) was higher in children than in adults, whereas for seasonal A(H3N2), it was similar in children and adults. The estimated SAPs were similar for seasonal A(H3N2) and pandemic A(H1N1) after excluding persons with higher baseline antibody titers from analysis. CONCLUSIONS: Pandemic and seasonal influenza A viruses had similar age-specific transmissibility in a cohort of initially uninfected households, after adjustment for baseline immunity.
Authors: Thorsten Suess; Udo Buchholz; Susann Dupke; Roland Grunow; Matthias an der Heiden; Alla Heider; Barbara Biere; Brunhilde Schweiger; Walter Haas; Gérard Krause Journal: Am J Epidemiol Date: 2010-05-03 Impact factor: 4.897
Authors: Laurent Coudeville; Fabrice Bailleux; Benjamin Riche; Françoise Megas; Philippe Andre; René Ecochard Journal: BMC Med Res Methodol Date: 2010-03-08 Impact factor: 4.615
Authors: Elizabeth Miller; Katja Hoschler; Pia Hardelid; Elaine Stanford; Nick Andrews; Maria Zambon Journal: Lancet Date: 2010-01-21 Impact factor: 79.321
Authors: Benjamin J Cowling; Kwok-Hung Chan; Vicky J Fang; Calvin K Y Cheng; Rita O P Fung; Winnie Wai; Joey Sin; Wing Hong Seto; Raymond Yung; Daniel W S Chu; Billy C F Chiu; Paco W Y Lee; Ming Chi Chiu; Hoi Che Lee; Timothy M Uyeki; Peter M Houck; J S Malik Peiris; Gabriel M Leung Journal: Ann Intern Med Date: 2009-08-03 Impact factor: 25.391
Authors: Simon Cauchemez; Christl A Donnelly; Carrie Reed; Azra C Ghani; Christophe Fraser; Charlotte K Kent; Lyn Finelli; Neil M Ferguson Journal: N Engl J Med Date: 2009-12-31 Impact factor: 91.245
Authors: Yang Yang; Jonathan D Sugimoto; M Elizabeth Halloran; Nicole E Basta; Dennis L Chao; Laura Matrajt; Gail Potter; Eben Kenah; Ira M Longini Journal: Science Date: 2009-09-10 Impact factor: 47.728
Authors: Lincoln L H Lau; Hiroshi Nishiura; Heath Kelly; Dennis K M Ip; Gabriel M Leung; Benjamin J Cowling Journal: Epidemiology Date: 2012-07 Impact factor: 4.822
Authors: Suzanne E Ohmit; Joshua G Petrie; Ryan E Malosh; Benjamin J Cowling; Mark G Thompson; David K Shay; Arnold S Monto Journal: Clin Infect Dis Date: 2013-02-14 Impact factor: 9.079
Authors: Tim K Tsang; Vicky J Fang; Ranawaka A P M Perera; Dennis K M Ip; Gabriel M Leung; J S Malik Peiris; Simon Cauchemez; Benjamin J Cowling Journal: Epidemiology Date: 2016-01 Impact factor: 4.822
Authors: Tim K Tsang; Benjamin J Cowling; Vicky J Fang; Kwok-Hung Chan; Dennis K M Ip; Gabriel M Leung; J S Malik Peiris; Simon Cauchemez Journal: J Infect Dis Date: 2015-04-15 Impact factor: 5.226
Authors: James M McCaw; Peter F Howard; Peter C Richmond; Michael Nissen; Theo Sloots; Stephen B Lambert; Michael Lai; Michael Greenberg; Terry Nolan; Jodie McVernon Journal: BMC Infect Dis Date: 2012-12-11 Impact factor: 3.090