| Literature DB >> 21874167 |
Ying Pu1, Zhi Zhu, Da Han, Huixia Liu, Jun Liu, Jie Liao, Kejing Zhang, Weihong Tan.
Abstract
This paper describes a simple and sensitive aptamer/graphene oxide (GO) based assay for insulin detection. GO can protect DNA from nuclease cleavage, but aptamers can be detached from the GO surface by specific target binding. This exposes the aptamers to enzymatic cleavage and releases the target for a new cycle. Cycling of targets leads to significant signal amplification and low LOD.Entities:
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Year: 2011 PMID: 21874167 PMCID: PMC5508966 DOI: 10.1039/c1an15407a
Source DB: PubMed Journal: Analyst ISSN: 0003-2654 Impact factor: 4.616